CENPS (centromere protein S)

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Gene Gene ontology Other IDs Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 378708
• Gene name: Centromere protein S
• Gene symbol: CENPS
• Synonyms (NCBI Gene): APITD1, CENP-S, FAAP16, MHF1
• Chromosome: 1
• Chromosome location: 1p36.22
• Summary: This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcrip

Gene ontology (GO) Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000712	Process	Resolution of meiotic recombination intermediates	IBA
GO:0000712	Process	Resolution of meiotic recombination intermediates	IMP	20347428
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IEA
GO:0000785	Component	Chromatin	IDA	20347429
GO:0000939	Component	Inner kinetochore	IPI	36085283
GO:0003677	Function	DNA binding	IDA	20347429
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IDA	20347429
GO:0003690	Function	Double-stranded DNA binding	IDA	20347428
GO:0005515	Function	Protein binding	IPI	20347429, 22304917, 23886707, 25416956, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	36085283
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006281	Process	DNA repair	IDA	20347429
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IDA	20347429
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	20347428
GO:0007059	Process	Chromosome segregation	NAS	36085283
GO:0031297	Process	Replication fork processing	IBA
GO:0031297	Process	Replication fork processing	IMP	20347428
GO:0031398	Process	Positive regulation of protein ubiquitination	TAS	20347428
GO:0036297	Process	Interstrand cross-link repair	IDA	20347429
GO:0043240	Component	Fanconi anaemia nuclear complex	IBA
GO:0043240	Component	Fanconi anaemia nuclear complex	IDA	20347428, 20347429
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0051301	Process	Cell division	IEA
GO:0071821	Component	FANCM-MHF complex	IBA
GO:0071821	Component	FANCM-MHF complex	IDA	20347428
GO:0071821	Component	FANCM-MHF complex	IEA
GO:0071821	Component	FANCM-MHF complex	IPI	20347429

Other IDs

• MIM: 609130
• HGNC: 23163
• e!Ensembl: ENSG00000175279

Interactions View interactions

Pathways

KEGG Pathway	Reactome Pathway
Fanconi anemia pathway	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
	Separation of Sister Chromatids
	Resolution of Sister Chromatid Cohesion
	RHO GTPases Activate Formins
	Deposition of new CENPA-containing nucleosomes at the centromere
	Fanconi Anemia Pathway
	Mitotic Prometaphase
	EML4 and NUDC in mitotic spindle formation

Related Genes

Sort by: Blended Diseases Pathways Evidence source

CENPS-CORT 8 shared pathwaysFanconi anemia pathway, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids, Resolution of Sister Chromatid Cohesion, RHO GTPases Activate Formins, Deposition of new CENPA-containing nucleosomes at the centromere, Mitotic Prometaphase, EML4 and NUDC in mitotic spindle formation Related via 8 shared pathways including Fanconi anemia pathway, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal. CENPA 7 shared pathwaysAmplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids, Resolution of Sister Chromatid Cohesion, RHO GTPases Activate Formins, Deposition of new CENPA-containing nucleosomes at the centromere, Mitotic Prometaphase, EML4 and NUDC in mitotic spindle formation Related via 7 shared pathways including Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids. CENPC 7 shared pathwaysAmplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids, Resolution of Sister Chromatid Cohesion, RHO GTPases Activate Formins, Deposition of new CENPA-containing nucleosomes at the centromere, Mitotic Prometaphase, EML4 and NUDC in mitotic spindle formation Related via 7 shared pathways including Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids. CENPI 7 shared pathwaysAmplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids, Resolution of Sister Chromatid Cohesion, RHO GTPases Activate Formins, Deposition of new CENPA-containing nucleosomes at the centromere, Mitotic Prometaphase, EML4 and NUDC in mitotic spindle formation Related via 7 shared pathways including Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids. CENPP 7 shared pathwaysAmplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids, Resolution of Sister Chromatid Cohesion, RHO GTPases Activate Formins, Deposition of new CENPA-containing nucleosomes at the centromere, Mitotic Prometaphase, EML4 and NUDC in mitotic spindle formation Related via 7 shared pathways including Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Separation of Sister Chromatids.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
CENPS-CORT	0	[]	8	["Fanconi anemia pathway","Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal","Separation of Sister Chromatids","Resolution of Sister Chromatid Cohesion","RHO GTPases Activate Formins","Deposition of new CENPA-containing nucleosomes at the centromere","Mitotic Prometaphase","EML4 and NUDC in mitotic spindle formation"]	0	[]
CENPA	0	[]	7	["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal","Separation of Sister Chromatids","Resolution of Sister Chromatid Cohesion","RHO GTPases Activate Formins","Deposition of new CENPA-containing nucleosomes at the centromere","Mitotic Prometaphase","EML4 and NUDC in mitotic spindle formation"]	0	[]
CENPC	0	[]	7	["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal","Separation of Sister Chromatids","Resolution of Sister Chromatid Cohesion","RHO GTPases Activate Formins","Deposition of new CENPA-containing nucleosomes at the centromere","Mitotic Prometaphase","EML4 and NUDC in mitotic spindle formation"]	0	[]
CENPI	0	[]	7	["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal","Separation of Sister Chromatids","Resolution of Sister Chromatid Cohesion","RHO GTPases Activate Formins","Deposition of new CENPA-containing nucleosomes at the centromere","Mitotic Prometaphase","EML4 and NUDC in mitotic spindle formation"]	0	[]
CENPP	0	[]	7	["Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal","Separation of Sister Chromatids","Resolution of Sister Chromatid Cohesion","RHO GTPases Activate Formins","Deposition of new CENPA-containing nucleosomes at the centromere","Mitotic Prometaphase","EML4 and NUDC in mitotic spindle formation"]	0	[]

Diseases Linked via Similar Genes

Ankylosing spondylitis Linked via 1 of 5 related genesCENPA Hepatocellular carcinoma Linked via 1 of 5 related genesCENPA Color vision deficiency Linked via 1 of 5 related genesCENPC Crest syndrome Linked via 1 of 5 related genesCENPC Crst syndrome Linked via 1 of 5 related genesCENPC

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Ankylosing spondylitis	1	["CENPA"]
Hepatocellular carcinoma	1	["CENPA"]
Color vision deficiency	1	["CENPC"]
Crest syndrome	1	["CENPC"]
Crst syndrome	1	["CENPC"]