CD1B (CD1b molecule)

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Gene Gene information from NCBI Gene database.
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Entrez ID 910
Gene name CD1b molecule
Gene symbol CD1B
Synonyms (NCBI Gene)
CD1CD1AR1
Chromosome 1
Chromosome location 1q23.1
Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation o
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0001916 Process Positive regulation of T cell mediated cytotoxicity IBA
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0005515 Function Protein binding IPI 12118248, 14764708, 28514442, 33961781
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
188360 1635 ENSG00000158485
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P29016
Protein name T-cell surface glycoprotein CD1b (CD antigen CD1b)
Protein function Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
PDB 1GZP , 1GZQ , 1UQS , 2H26 , 3OV6 , 3T8X , 4ONO , 5C9J , 5L2J , 5L2K , 5WKE , 5WKG , 5WKI , 5WL1 , 6CUG , 6D64 , 8DV3 , 8DV4 , 8GLE , 8GLF , 8GLG , 8GLH , 8GLI , 8ZOX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07654 C1-set 210 → 286 Immunoglobulin C1-set domain Domain
PF16497 MHC_I_3 1 → 198 MHC-I family domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Sequence
Sequence length 333
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Tight junction Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Hematopoietic cell lineage  
Amoebiasis  
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CD1A 4 shared pathwaysTight junction, Hematopoietic cell lineage, Amoebiasis, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Related via 4 shared pathways including Tight junction, Hematopoietic cell lineage. CD1C 4 shared pathwaysTight junction, Hematopoietic cell lineage, Amoebiasis, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Related via 4 shared pathways including Tight junction, Hematopoietic cell lineage. CD1D 4 shared pathwaysTight junction, Hematopoietic cell lineage, Amoebiasis, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Related via 4 shared pathways including Tight junction, Hematopoietic cell lineage. CD1E 3 shared pathwaysTight junction, Hematopoietic cell lineage, Amoebiasis Related via 3 shared pathways including Tight junction, Hematopoietic cell lineage. CD33 2 shared pathwaysHematopoietic cell lineage, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Related via 2 shared pathways including Hematopoietic cell lineage, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Color vision deficiency Linked via 2 of 5 related genesCD1A, CD1D Scoliosis Linked via 1 of 5 related genesCD1E Alzheimer disease Linked via 1 of 5 related genesCD33 Dementia Linked via 1 of 5 related genesCD33 Myeloid leukemia Linked via 1 of 5 related genesCD33