B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84002
• Gene name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
• Gene symbol: B3GNT5
• Synonyms (NCBI Gene): B3GN-T5, beta3Gn-T5
• Chromosome: 3
• Chromosome location: 3q27.1
• Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactot

miRNA Show/Hide all (149)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019068	hsa-miR-335-5p	Microarray	18185580
MIRT023460	hsa-miR-30b-5p	Sequencing	20371350
MIRT024816	hsa-miR-215-5p	Microarray	19074876
MIRT026906	hsa-miR-192-5p	Microarray	19074876
MIRT031039	hsa-miR-21-5p	Microarray	18591254
MIRT047995	hsa-miR-30c-5p	CLASH	23622248
MIRT047723	hsa-miR-10a-5p	CLASH	23622248
MIRT813358	hsa-miR-1183	CLIP-seq
MIRT813359	hsa-miR-1323	CLIP-seq
MIRT813360	hsa-miR-203	CLIP-seq
MIRT813361	hsa-miR-3143	CLIP-seq
MIRT813362	hsa-miR-3163	CLIP-seq
MIRT813363	hsa-miR-3613-5p	CLIP-seq
MIRT813364	hsa-miR-409-3p	CLIP-seq
MIRT813365	hsa-miR-4282	CLIP-seq
MIRT813366	hsa-miR-452	CLIP-seq
MIRT813367	hsa-miR-4676-3p	CLIP-seq
MIRT813368	hsa-miR-543	CLIP-seq
MIRT813369	hsa-miR-548o	CLIP-seq
MIRT813370	hsa-miR-579	CLIP-seq
MIRT813371	hsa-miR-944	CLIP-seq
MIRT813358	hsa-miR-1183	CLIP-seq
MIRT1940444	hsa-miR-2052	CLIP-seq
MIRT1940445	hsa-miR-2054	CLIP-seq
MIRT1940446	hsa-miR-3120-5p	CLIP-seq
MIRT1940447	hsa-miR-3124-3p	CLIP-seq
MIRT1940448	hsa-miR-370	CLIP-seq
MIRT813364	hsa-miR-409-3p	CLIP-seq
MIRT1940449	hsa-miR-4703-3p	CLIP-seq
MIRT1940450	hsa-miR-489	CLIP-seq
MIRT1940451	hsa-miR-511	CLIP-seq
MIRT1940452	hsa-miR-514	CLIP-seq
MIRT1940453	hsa-miR-514b-3p	CLIP-seq
MIRT1940454	hsa-miR-548c-3p	CLIP-seq
MIRT1940455	hsa-miR-561	CLIP-seq
MIRT1940456	hsa-miR-587	CLIP-seq
MIRT813358	hsa-miR-1183	CLIP-seq
MIRT2179348	hsa-miR-1297	CLIP-seq
MIRT2179349	hsa-miR-1305	CLIP-seq
MIRT2179350	hsa-miR-141	CLIP-seq
MIRT2179351	hsa-miR-1913	CLIP-seq
MIRT2179352	hsa-miR-200a	CLIP-seq
MIRT813360	hsa-miR-203	CLIP-seq
MIRT2179353	hsa-miR-204	CLIP-seq
MIRT1940445	hsa-miR-2054	CLIP-seq
MIRT2179354	hsa-miR-208a	CLIP-seq
MIRT2179355	hsa-miR-208b	CLIP-seq
MIRT2179356	hsa-miR-211	CLIP-seq
MIRT2179357	hsa-miR-221	CLIP-seq
MIRT2179358	hsa-miR-222	CLIP-seq
MIRT2179359	hsa-miR-26a	CLIP-seq
MIRT2179360	hsa-miR-26b	CLIP-seq
MIRT2179361	hsa-miR-29a	CLIP-seq
MIRT2179362	hsa-miR-29b	CLIP-seq
MIRT2179363	hsa-miR-29c	CLIP-seq
MIRT2179364	hsa-miR-300	CLIP-seq
MIRT2179365	hsa-miR-302a	CLIP-seq
MIRT2179366	hsa-miR-302b	CLIP-seq
MIRT2179367	hsa-miR-302c	CLIP-seq
MIRT2179368	hsa-miR-302d	CLIP-seq
MIRT2179369	hsa-miR-302e	CLIP-seq
MIRT2179370	hsa-miR-30a	CLIP-seq
MIRT2179371	hsa-miR-30b	CLIP-seq
MIRT2179372	hsa-miR-30c	CLIP-seq
MIRT2179373	hsa-miR-30d	CLIP-seq
MIRT2179374	hsa-miR-30e	CLIP-seq
MIRT2179375	hsa-miR-3117-5p	CLIP-seq
MIRT1940446	hsa-miR-3120-5p	CLIP-seq
MIRT1940447	hsa-miR-3124-3p	CLIP-seq
MIRT813361	hsa-miR-3143	CLIP-seq
MIRT2179376	hsa-miR-324-3p	CLIP-seq
MIRT2179377	hsa-miR-3591-3p	CLIP-seq
MIRT2179378	hsa-miR-3607-3p	CLIP-seq
MIRT813363	hsa-miR-3613-5p	CLIP-seq
MIRT2179379	hsa-miR-3660	CLIP-seq
MIRT2179380	hsa-miR-3663-3p	CLIP-seq
MIRT2179381	hsa-miR-3675-3p	CLIP-seq
MIRT2179382	hsa-miR-3686	CLIP-seq
MIRT2179383	hsa-miR-372	CLIP-seq
MIRT2179384	hsa-miR-373	CLIP-seq
MIRT2179385	hsa-miR-381	CLIP-seq
MIRT813364	hsa-miR-409-3p	CLIP-seq
MIRT2179386	hsa-miR-4264	CLIP-seq
MIRT2179387	hsa-miR-4272	CLIP-seq
MIRT2179388	hsa-miR-4276	CLIP-seq
MIRT813365	hsa-miR-4282	CLIP-seq
MIRT2179389	hsa-miR-4307	CLIP-seq
MIRT2179390	hsa-miR-4435	CLIP-seq
MIRT2179391	hsa-miR-4446-5p	CLIP-seq
MIRT2179392	hsa-miR-4464	CLIP-seq
MIRT2179393	hsa-miR-4465	CLIP-seq
MIRT2179394	hsa-miR-4526	CLIP-seq
MIRT2179395	hsa-miR-4528	CLIP-seq
MIRT2179396	hsa-miR-4536	CLIP-seq
MIRT2179397	hsa-miR-4643	CLIP-seq
MIRT2179398	hsa-miR-4645-3p	CLIP-seq
MIRT2179399	hsa-miR-4652-3p	CLIP-seq
MIRT2179400	hsa-miR-4659a-5p	CLIP-seq
MIRT2179401	hsa-miR-4659b-5p	CLIP-seq
MIRT2179402	hsa-miR-466	CLIP-seq
MIRT2179403	hsa-miR-4668-3p	CLIP-seq
MIRT2179404	hsa-miR-4684-5p	CLIP-seq
MIRT2179405	hsa-miR-4699-3p	CLIP-seq
MIRT2179406	hsa-miR-4718	CLIP-seq
MIRT2179407	hsa-miR-4728-3p	CLIP-seq
MIRT2179408	hsa-miR-4748	CLIP-seq
MIRT2179409	hsa-miR-4749-3p	CLIP-seq
MIRT2179410	hsa-miR-4755-5p	CLIP-seq
MIRT2179411	hsa-miR-4764-5p	CLIP-seq
MIRT2179412	hsa-miR-4768-5p	CLIP-seq
MIRT2179413	hsa-miR-4775	CLIP-seq
MIRT2179414	hsa-miR-4776-3p	CLIP-seq
MIRT2179415	hsa-miR-4789-3p	CLIP-seq
MIRT2179416	hsa-miR-4797-3p	CLIP-seq
MIRT2179417	hsa-miR-4802-3p	CLIP-seq
MIRT2179418	hsa-miR-490-5p	CLIP-seq
MIRT2179419	hsa-miR-502-5p	CLIP-seq
MIRT1940451	hsa-miR-511	CLIP-seq
MIRT2179420	hsa-miR-520a-3p	CLIP-seq
MIRT2179421	hsa-miR-520b	CLIP-seq
MIRT2179422	hsa-miR-520c-3p	CLIP-seq
MIRT2179423	hsa-miR-520d-3p	CLIP-seq
MIRT2179424	hsa-miR-520e	CLIP-seq
MIRT2179425	hsa-miR-542-3p	CLIP-seq
MIRT813368	hsa-miR-543	CLIP-seq
MIRT1940454	hsa-miR-548c-3p	CLIP-seq
MIRT1940455	hsa-miR-561	CLIP-seq
MIRT2179426	hsa-miR-568	CLIP-seq
MIRT2179427	hsa-miR-570	CLIP-seq
MIRT813370	hsa-miR-579	CLIP-seq
MIRT1940456	hsa-miR-587	CLIP-seq
MIRT2179428	hsa-miR-590-3p	CLIP-seq
MIRT2179429	hsa-miR-591	CLIP-seq
MIRT2179430	hsa-miR-595	CLIP-seq
MIRT2179431	hsa-miR-598	CLIP-seq
MIRT2179432	hsa-miR-623	CLIP-seq
MIRT2179433	hsa-miR-624	CLIP-seq
MIRT2179434	hsa-miR-628-5p	CLIP-seq
MIRT2179435	hsa-miR-664	CLIP-seq
MIRT2179436	hsa-miR-670	CLIP-seq
MIRT2179437	hsa-miR-891b	CLIP-seq
MIRT2179438	hsa-miR-892a	CLIP-seq
MIRT2179439	hsa-miR-942	CLIP-seq
MIRT813371	hsa-miR-944	CLIP-seq
MIRT2675821	hsa-miR-3920	CLIP-seq
MIRT2179391	hsa-miR-4446-5p	CLIP-seq
MIRT2179410	hsa-miR-4755-5p	CLIP-seq
MIRT2675822	hsa-miR-552	CLIP-seq
MIRT2675823	hsa-miR-764	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005794	Component	Golgi apparatus	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006486	Process	Protein glycosylation	TAS	11384981
GO:0006493	Process	Protein O-linked glycosylation	IBA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006688	Process	Glycosphingolipid biosynthetic process	TAS
GO:0007417	Process	Central nervous system development	IDA	11384981
GO:0008499	Function	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	TAS
GO:0009247	Process	Glycolipid biosynthetic process	TAS	11384981
GO:0016020	Component	Membrane	IEA
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IBA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016758	Function	Hexosyltransferase activity	IEA
GO:0030148	Process	Sphingolipid biosynthetic process	IEA
GO:0047256	Function	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity	IDA	11384981
GO:0047256	Function	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity	IEA
GO:0047256	Function	Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity	TAS
GO:1901137	Process	Carbohydrate derivative biosynthetic process	IEA

Other IDs

• MIM: 615333
• HGNC: 15684
• e!Ensembl: ENSG00000176597

Protein

• UniProt ID: Q9BYG0
• Protein name: Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (EC 2.4.1.206) (Lactotriaosylceramide synthase) (Lc(3)Cer synthase) (Lc3 synthase) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5) (BGnT-5) (Beta-1,3-Gn-T5) (Beta-1,3-N-acetylgl
• Protein function: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong ac
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01762	Galactosyl_T	102 → 301	Galactosyltransferase	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus. {ECO:0000269|PubMed:11283017}.
• Sequence:

  MRMLVSGRRVKKWQLIIQLFATCFLASLMFFWEPIDNHIVSHMKSYSYRYLINSYDFVND
  TLSLKHTSAGPRYQYLINHKEKCQAQDVLLLLFVKTAPENYDRRSGIRRTWGNENYVRSQ
  LNANIKTLFALGTPNPLEGEELQRKLAWEDQRYNDIIQQDFVDSFYNLTLKLLMQFSWAN
  TYCPHAKFLMTADDDIFIHMPNLIEYLQSLEQIGVQDFWIGRVHRGAPPIRDKSSKYYVS
  YEMYQWPAYPDYTAGAAYVISGDVAAKVYEASQTLNSSLYIDDVFMGLCANKIGIVPQDH
  VFFSGEGKTPYHPCIYEKMMTSHGHLEDLQDLWKNATDPKVKTISKGFFGQIYCRLMKII
  LLCKISYVDTYPCRAAFI

• Sequence length: 378

Pathways

KEGG Pathway	Reactome Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series	O-linked glycosylation of mucins
Metabolic pathways

Related Genes

Sort by: Blended Diseases Pathways Evidence source

B3GNT4 2 shared pathwaysGlycosphingolipid biosynthesis - lacto and neolacto series, O-linked glycosylation of mucins Related via 2 shared pathways including Glycosphingolipid biosynthesis - lacto and neolacto series, O-linked glycosylation of mucins. B3GNT3 2 shared pathwaysGlycosphingolipid biosynthesis - lacto and neolacto series, O-linked glycosylation of mucins Related via 2 shared pathways including Glycosphingolipid biosynthesis - lacto and neolacto series, O-linked glycosylation of mucins. B3GNT2 2 shared pathwaysGlycosphingolipid biosynthesis - lacto and neolacto series, O-linked glycosylation of mucins Related via 2 shared pathways including Glycosphingolipid biosynthesis - lacto and neolacto series, O-linked glycosylation of mucins.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
B3GNT4	0	[]	2	["Glycosphingolipid biosynthesis - lacto and neolacto series","O-linked glycosylation of mucins"]	0	[]
B3GNT3	0	[]	2	["Glycosphingolipid biosynthesis - lacto and neolacto series","O-linked glycosylation of mucins"]	0	[]
B3GNT2	0	[]	2	["Glycosphingolipid biosynthesis - lacto and neolacto series","O-linked glycosylation of mucins"]	0	[]

Diseases Linked via Similar Genes

Deafness Linked via 1 of 3 related genesB3GNT4 Hearing loss Linked via 1 of 3 related genesB3GNT4 Alzheimer disease Linked via 1 of 3 related genesB3GNT2 Rheumatoid arthritis Linked via 1 of 3 related genesB3GNT2 Coronary artery disease Linked via 1 of 3 related genesB3GNT2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Deafness	1	["B3GNT4"]
Hearing loss	1	["B3GNT4"]
Alzheimer disease	1	["B3GNT2"]
Rheumatoid arthritis	1	["B3GNT2"]
Coronary artery disease	1	["B3GNT2"]