ARHGDIB (Rho GDP dissociation inhibitor beta)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 397
• Gene name: Rho GDP dissociation inhibitor beta
• Gene symbol: ARHGDIB
• Synonyms (NCBI Gene): D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2
• Chromosome: 12
• Chromosome location: 12p12.3
• Summary: Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The G

miRNA Show/Hide all (227)

miRTarBase ID	miRNA	Experiments	Reference
MIRT437939	hsa-miR-34a-5p	Western blot, Luciferase reporter assay	23349340
MIRT437939	hsa-miR-34a-5p	Western blot, Luciferase reporter assay	23349340
MIRT795198	hsa-miR-3688-5p	CLIP-seq
MIRT795199	hsa-miR-4711-5p	CLIP-seq
MIRT2174542	hsa-miR-1207-5p	CLIP-seq
MIRT2174543	hsa-miR-1291	CLIP-seq
MIRT2174544	hsa-miR-134	CLIP-seq
MIRT2174545	hsa-miR-1909	CLIP-seq
MIRT2174546	hsa-miR-3118	CLIP-seq
MIRT2174547	hsa-miR-3128	CLIP-seq
MIRT2174548	hsa-miR-3134	CLIP-seq
MIRT2174549	hsa-miR-3164	CLIP-seq
MIRT2174550	hsa-miR-328	CLIP-seq
MIRT2174551	hsa-miR-383	CLIP-seq
MIRT2174552	hsa-miR-4257	CLIP-seq
MIRT2174553	hsa-miR-4419a	CLIP-seq
MIRT2174554	hsa-miR-4469	CLIP-seq
MIRT2174555	hsa-miR-4501	CLIP-seq
MIRT2174556	hsa-miR-4510	CLIP-seq
MIRT2174557	hsa-miR-4511	CLIP-seq
MIRT2174558	hsa-miR-4534	CLIP-seq
MIRT2174559	hsa-miR-4640-5p	CLIP-seq
MIRT2174560	hsa-miR-4720-5p	CLIP-seq
MIRT2174561	hsa-miR-4726-5p	CLIP-seq
MIRT2174562	hsa-miR-4736	CLIP-seq
MIRT2174563	hsa-miR-4763-3p	CLIP-seq
MIRT2174564	hsa-miR-4764-5p	CLIP-seq
MIRT2174565	hsa-miR-4799-3p	CLIP-seq
MIRT2174566	hsa-miR-4802-5p	CLIP-seq
MIRT2174567	hsa-miR-642a	CLIP-seq
MIRT2174568	hsa-miR-657	CLIP-seq
MIRT2174569	hsa-miR-765	CLIP-seq
MIRT2174542	hsa-miR-1207-5p	CLIP-seq
MIRT2478025	hsa-miR-1243	CLIP-seq
MIRT2478026	hsa-miR-1245	CLIP-seq
MIRT2478027	hsa-miR-1262	CLIP-seq
MIRT2478028	hsa-miR-1273e	CLIP-seq
MIRT2478029	hsa-miR-1273f	CLIP-seq
MIRT2174543	hsa-miR-1291	CLIP-seq
MIRT2478030	hsa-miR-1321	CLIP-seq
MIRT2478031	hsa-miR-143	CLIP-seq
MIRT2478032	hsa-miR-186	CLIP-seq
MIRT2174545	hsa-miR-1909	CLIP-seq
MIRT2478033	hsa-miR-2110	CLIP-seq
MIRT2478034	hsa-miR-219-5p	CLIP-seq
MIRT2478035	hsa-miR-31	CLIP-seq
MIRT2478036	hsa-miR-3123	CLIP-seq
MIRT2478037	hsa-miR-3126-3p	CLIP-seq
MIRT2478038	hsa-miR-3126-5p	CLIP-seq
MIRT2174547	hsa-miR-3128	CLIP-seq
MIRT2174548	hsa-miR-3134	CLIP-seq
MIRT2478039	hsa-miR-3138	CLIP-seq
MIRT2478040	hsa-miR-3153	CLIP-seq
MIRT2478041	hsa-miR-3156-5p	CLIP-seq
MIRT2478042	hsa-miR-3165	CLIP-seq
MIRT2478043	hsa-miR-3176	CLIP-seq
MIRT2478044	hsa-miR-3177-5p	CLIP-seq
MIRT2478045	hsa-miR-3190	CLIP-seq
MIRT2174550	hsa-miR-328	CLIP-seq
MIRT2478046	hsa-miR-342-3p	CLIP-seq
MIRT2478047	hsa-miR-34a	CLIP-seq
MIRT2478048	hsa-miR-34c-5p	CLIP-seq
MIRT2478049	hsa-miR-3606	CLIP-seq
MIRT2478050	hsa-miR-3617	CLIP-seq
MIRT2478051	hsa-miR-3646	CLIP-seq
MIRT2478052	hsa-miR-3654	CLIP-seq
MIRT795198	hsa-miR-3688-5p	CLIP-seq
MIRT2478053	hsa-miR-3691-5p	CLIP-seq
MIRT2174551	hsa-miR-383	CLIP-seq
MIRT2478054	hsa-miR-3922-3p	CLIP-seq
MIRT2478055	hsa-miR-3936	CLIP-seq
MIRT2478056	hsa-miR-3940-3p	CLIP-seq
MIRT2174552	hsa-miR-4257	CLIP-seq
MIRT2478057	hsa-miR-4270	CLIP-seq
MIRT2478058	hsa-miR-4271	CLIP-seq
MIRT2478059	hsa-miR-4273	CLIP-seq
MIRT2478060	hsa-miR-4324	CLIP-seq
MIRT2174553	hsa-miR-4419a	CLIP-seq
MIRT2478061	hsa-miR-4441	CLIP-seq
MIRT2478062	hsa-miR-4445	CLIP-seq
MIRT2174554	hsa-miR-4469	CLIP-seq
MIRT2478063	hsa-miR-449a	CLIP-seq
MIRT2478064	hsa-miR-449b	CLIP-seq
MIRT2174555	hsa-miR-4501	CLIP-seq
MIRT2478065	hsa-miR-4503	CLIP-seq
MIRT2174556	hsa-miR-4510	CLIP-seq
MIRT2174557	hsa-miR-4511	CLIP-seq
MIRT2478066	hsa-miR-4520a-3p	CLIP-seq
MIRT2174558	hsa-miR-4534	CLIP-seq
MIRT2174559	hsa-miR-4640-5p	CLIP-seq
MIRT2478067	hsa-miR-4641	CLIP-seq
MIRT2478068	hsa-miR-4651	CLIP-seq
MIRT2478069	hsa-miR-4658	CLIP-seq
MIRT2478070	hsa-miR-4668-5p	CLIP-seq
MIRT2478071	hsa-miR-4677-5p	CLIP-seq
MIRT2478072	hsa-miR-4701-3p	CLIP-seq
MIRT2478073	hsa-miR-4708-5p	CLIP-seq
MIRT2478074	hsa-miR-4709-3p	CLIP-seq
MIRT795199	hsa-miR-4711-5p	CLIP-seq
MIRT2478075	hsa-miR-4719	CLIP-seq
MIRT2174560	hsa-miR-4720-5p	CLIP-seq
MIRT2478076	hsa-miR-4725-3p	CLIP-seq
MIRT2174561	hsa-miR-4726-5p	CLIP-seq
MIRT2174562	hsa-miR-4736	CLIP-seq
MIRT2478077	hsa-miR-4739	CLIP-seq
MIRT2478078	hsa-miR-4756-5p	CLIP-seq
MIRT2478079	hsa-miR-4757-5p	CLIP-seq
MIRT2478080	hsa-miR-4758-5p	CLIP-seq
MIRT2174563	hsa-miR-4763-3p	CLIP-seq
MIRT2174564	hsa-miR-4764-5p	CLIP-seq
MIRT2478081	hsa-miR-4765	CLIP-seq
MIRT2478082	hsa-miR-4770	CLIP-seq
MIRT2478083	hsa-miR-4779	CLIP-seq
MIRT2478084	hsa-miR-4782-3p	CLIP-seq
MIRT2174565	hsa-miR-4799-3p	CLIP-seq
MIRT2478085	hsa-miR-4800-5p	CLIP-seq
MIRT2174566	hsa-miR-4802-5p	CLIP-seq
MIRT2478086	hsa-miR-491-5p	CLIP-seq
MIRT2478087	hsa-miR-508-3p	CLIP-seq
MIRT2478088	hsa-miR-555	CLIP-seq
MIRT2478089	hsa-miR-606	CLIP-seq
MIRT2478090	hsa-miR-608	CLIP-seq
MIRT2478091	hsa-miR-641	CLIP-seq
MIRT2174567	hsa-miR-642a	CLIP-seq
MIRT2478092	hsa-miR-645	CLIP-seq
MIRT2478093	hsa-miR-653	CLIP-seq
MIRT2174568	hsa-miR-657	CLIP-seq
MIRT2478094	hsa-miR-7	CLIP-seq
MIRT2478095	hsa-miR-711	CLIP-seq
MIRT2174569	hsa-miR-765	CLIP-seq
MIRT2478096	hsa-miR-921	CLIP-seq
MIRT2174542	hsa-miR-1207-5p	CLIP-seq
MIRT2478026	hsa-miR-1245	CLIP-seq
MIRT2478027	hsa-miR-1262	CLIP-seq
MIRT2478028	hsa-miR-1273e	CLIP-seq
MIRT2478029	hsa-miR-1273f	CLIP-seq
MIRT2174543	hsa-miR-1291	CLIP-seq
MIRT2478030	hsa-miR-1321	CLIP-seq
MIRT2174544	hsa-miR-134	CLIP-seq
MIRT2478031	hsa-miR-143	CLIP-seq
MIRT2478032	hsa-miR-186	CLIP-seq
MIRT2174545	hsa-miR-1909	CLIP-seq
MIRT2478033	hsa-miR-2110	CLIP-seq
MIRT2478034	hsa-miR-219-5p	CLIP-seq
MIRT2478035	hsa-miR-31	CLIP-seq
MIRT2174546	hsa-miR-3118	CLIP-seq
MIRT2478036	hsa-miR-3123	CLIP-seq
MIRT2478037	hsa-miR-3126-3p	CLIP-seq
MIRT2478038	hsa-miR-3126-5p	CLIP-seq
MIRT2174547	hsa-miR-3128	CLIP-seq
MIRT2174548	hsa-miR-3134	CLIP-seq
MIRT2478039	hsa-miR-3138	CLIP-seq
MIRT2478040	hsa-miR-3153	CLIP-seq
MIRT2478041	hsa-miR-3156-5p	CLIP-seq
MIRT2174549	hsa-miR-3164	CLIP-seq
MIRT2478042	hsa-miR-3165	CLIP-seq
MIRT2478043	hsa-miR-3176	CLIP-seq
MIRT2478044	hsa-miR-3177-5p	CLIP-seq
MIRT2478045	hsa-miR-3190	CLIP-seq
MIRT2174550	hsa-miR-328	CLIP-seq
MIRT2478046	hsa-miR-342-3p	CLIP-seq
MIRT2478047	hsa-miR-34a	CLIP-seq
MIRT2478048	hsa-miR-34c-5p	CLIP-seq
MIRT2478049	hsa-miR-3606	CLIP-seq
MIRT2478050	hsa-miR-3617	CLIP-seq
MIRT2478051	hsa-miR-3646	CLIP-seq
MIRT795198	hsa-miR-3688-5p	CLIP-seq
MIRT2478053	hsa-miR-3691-5p	CLIP-seq
MIRT2174551	hsa-miR-383	CLIP-seq
MIRT2478054	hsa-miR-3922-3p	CLIP-seq
MIRT2478055	hsa-miR-3936	CLIP-seq
MIRT2478056	hsa-miR-3940-3p	CLIP-seq
MIRT2174552	hsa-miR-4257	CLIP-seq
MIRT2478057	hsa-miR-4270	CLIP-seq
MIRT2478058	hsa-miR-4271	CLIP-seq
MIRT2478059	hsa-miR-4273	CLIP-seq
MIRT2478060	hsa-miR-4324	CLIP-seq
MIRT2174553	hsa-miR-4419a	CLIP-seq
MIRT2478061	hsa-miR-4441	CLIP-seq
MIRT2478062	hsa-miR-4445	CLIP-seq
MIRT2174554	hsa-miR-4469	CLIP-seq
MIRT2478063	hsa-miR-449a	CLIP-seq
MIRT2478064	hsa-miR-449b	CLIP-seq
MIRT2174555	hsa-miR-4501	CLIP-seq
MIRT2478065	hsa-miR-4503	CLIP-seq
MIRT2174556	hsa-miR-4510	CLIP-seq
MIRT2174557	hsa-miR-4511	CLIP-seq
MIRT2478066	hsa-miR-4520a-3p	CLIP-seq
MIRT2174558	hsa-miR-4534	CLIP-seq
MIRT2478067	hsa-miR-4641	CLIP-seq
MIRT2478068	hsa-miR-4651	CLIP-seq
MIRT2478069	hsa-miR-4658	CLIP-seq
MIRT2478070	hsa-miR-4668-5p	CLIP-seq
MIRT2478071	hsa-miR-4677-5p	CLIP-seq
MIRT2478072	hsa-miR-4701-3p	CLIP-seq
MIRT2478073	hsa-miR-4708-5p	CLIP-seq
MIRT2478074	hsa-miR-4709-3p	CLIP-seq
MIRT795199	hsa-miR-4711-5p	CLIP-seq
MIRT2478075	hsa-miR-4719	CLIP-seq
MIRT2174560	hsa-miR-4720-5p	CLIP-seq
MIRT2478076	hsa-miR-4725-3p	CLIP-seq
MIRT2174562	hsa-miR-4736	CLIP-seq
MIRT2478077	hsa-miR-4739	CLIP-seq
MIRT2478078	hsa-miR-4756-5p	CLIP-seq
MIRT2478079	hsa-miR-4757-5p	CLIP-seq
MIRT2478080	hsa-miR-4758-5p	CLIP-seq
MIRT2174563	hsa-miR-4763-3p	CLIP-seq
MIRT2174564	hsa-miR-4764-5p	CLIP-seq
MIRT2478081	hsa-miR-4765	CLIP-seq
MIRT2478082	hsa-miR-4770	CLIP-seq
MIRT2478083	hsa-miR-4779	CLIP-seq
MIRT2478084	hsa-miR-4782-3p	CLIP-seq
MIRT2174565	hsa-miR-4799-3p	CLIP-seq
MIRT2478085	hsa-miR-4800-5p	CLIP-seq
MIRT2174566	hsa-miR-4802-5p	CLIP-seq
MIRT2478086	hsa-miR-491-5p	CLIP-seq
MIRT2478087	hsa-miR-508-3p	CLIP-seq
MIRT2478088	hsa-miR-555	CLIP-seq
MIRT2478090	hsa-miR-608	CLIP-seq
MIRT2478091	hsa-miR-641	CLIP-seq
MIRT2174567	hsa-miR-642a	CLIP-seq
MIRT2478093	hsa-miR-653	CLIP-seq
MIRT2174568	hsa-miR-657	CLIP-seq
MIRT2478094	hsa-miR-7	CLIP-seq
MIRT2478095	hsa-miR-711	CLIP-seq
MIRT2174569	hsa-miR-765	CLIP-seq
MIRT2478096	hsa-miR-921	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IMP	24554735
GO:0005094	Function	Rho GDP-dissociation inhibitor activity	IBA
GO:0005094	Function	Rho GDP-dissociation inhibitor activity	IDA	7512369, 8356058
GO:0005094	Function	Rho GDP-dissociation inhibitor activity	IEA
GO:0005094	Function	Rho GDP-dissociation inhibitor activity	TAS	8262133
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	7512369, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	10802295
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	TAS	16130169
GO:0007266	Process	Rho protein signal transduction	IBA
GO:0007266	Process	Rho protein signal transduction	IEA
GO:0016020	Component	Membrane	IBA
GO:0031267	Function	Small GTPase binding	IDA	7512369
GO:0031410	Component	Cytoplasmic vesicle	TAS	9113980
GO:0035023	Process	Regulation of Rho protein signal transduction	IDA	7512369
GO:0035023	Process	Regulation of Rho protein signal transduction	IMP	8262133
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:0071461	Process	Cellular response to redox state	IEA
GO:1901164	Process	Negative regulation of trophoblast cell migration	IDA	24554735

Other IDs

• MIM: 602843
• HGNC: 679
• e!Ensembl: ENSG00000111348

Protein

• UniProt ID: P52566
• Protein name: Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (Ly-GDI) (Rho-GDI beta)
• Protein function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:7512369, PubMed:8356058). Regulates reorganization of the actin cytoskeleton mediated
• PDB: 1DS6 , 5H1D
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02115	Rho_GDI	8 → 198	RHO protein GDP dissociation inhibitor	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in bone marrow, thymus and spleen. {ECO:0000269|PubMed:8356058}.
• Sequence:

  MTEKAPEPHVEEDDDDELDSKLNYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVT
  DPKAPNVVVTRLTLVCESAPGPITMDLTGDLEALKKETIVLKEGSEYRVKIHFKVNRDIV
  SGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTD
  DDKQDHLSWEWNLSIKKEWTE

• Sequence length: 201

Pathways

KEGG Pathway	Reactome Pathway
Neurotrophin signaling pathway	Rho GTPase cycle
Vasopressin-regulated water reabsorption

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ARHGDIG 3 shared pathwaysNeurotrophin signaling pathway, Vasopressin-regulated water reabsorption, Rho GTPase cycle Related via 3 shared pathways including Neurotrophin signaling pathway, Vasopressin-regulated water reabsorption. ARHGDIA 3 shared pathwaysNeurotrophin signaling pathway, Vasopressin-regulated water reabsorption, Rho GTPase cycle Related via 3 shared pathways including Neurotrophin signaling pathway, Vasopressin-regulated water reabsorption. SOS2 2 shared pathwaysNeurotrophin signaling pathway, Rho GTPase cycle Related via 2 shared pathways including Neurotrophin signaling pathway, Rho GTPase cycle. CDC42 2 shared pathwaysNeurotrophin signaling pathway, Rho GTPase cycle Related via 2 shared pathways including Neurotrophin signaling pathway, Rho GTPase cycle. RHOA 2 shared pathwaysNeurotrophin signaling pathway, Rho GTPase cycle Related via 2 shared pathways including Neurotrophin signaling pathway, Rho GTPase cycle.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ARHGDIG	0	[]	3	["Neurotrophin signaling pathway","Vasopressin-regulated water reabsorption","Rho GTPase cycle"]	0	[]
ARHGDIA	0	[]	3	["Neurotrophin signaling pathway","Vasopressin-regulated water reabsorption","Rho GTPase cycle"]	0	[]
SOS2	0	[]	2	["Neurotrophin signaling pathway","Rho GTPase cycle"]	0	[]
CDC42	0	[]	2	["Neurotrophin signaling pathway","Rho GTPase cycle"]	0	[]
RHOA	0	[]	2	["Neurotrophin signaling pathway","Rho GTPase cycle"]	0	[]

Diseases Linked via Similar Genes

Kidney disease Linked via 2 of 5 related genesARHGDIA, SOS2 Desbuquois syndrome Linked via 2 of 5 related genesSOS2, CDC42 Gout Linked via 2 of 5 related genesSOS2, RHOA Attention deficit hyperactivity disorder Linked via 2 of 5 related genesCDC42, RHOA Autism Linked via 2 of 5 related genesCDC42, RHOA

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Kidney disease	2	["ARHGDIA","SOS2"]
Desbuquois syndrome	2	["SOS2","CDC42"]
Gout	2	["SOS2","RHOA"]
Attention deficit hyperactivity disorder	2	["CDC42","RHOA"]
Autism	2	["CDC42","RHOA"]