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Gene Gene information from NCBI Gene database.
Entrez ID 10121
Gene name Actin related protein 1A
Gene symbol ACTR1A
Synonyms (NCBI Gene)
ARP1Arp1ACTRN1
Chromosome 10
Chromosome location 10q24.32
Summary This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions,
miRNA miRNA information provided by mirtarbase database.
781 Show/Hide all (781)
miRTarBase ID miRNA Experiments Reference
MIRT000806 hsa-miR-15a-5p proteomics analysis 18362358
MIRT000805 hsa-miR-16-5p proteomics analysis 18362358
MIRT049187 hsa-miR-92a-3p CLASH 23622248
MIRT049187 hsa-miR-92a-3p CLASH 23622248
MIRT047006 hsa-miR-210-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0005515 Function Protein binding IPI 28394342
GO:0005524 Function ATP binding IEA
GO:0005737 Component Cytoplasm IDA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605143 167 ENSG00000138107
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61163
Protein name Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Protein function Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00022 Actin 7 → 376 Actin Family
Sequence
Sequence length 376
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Motor proteins MHC class II antigen presentation
Amyotrophic lateral sclerosis Regulation of PLK1 Activity at G2/M Transition
Huntington disease HSP90 chaperone cycle for steroid hormone receptors (SHR)
Pathways of neurodegeneration - multiple diseases Loss of Nlp from mitotic centrosomes
Salmonella infection Recruitment of mitotic centrosome proteins and complexes
  Loss of proteins required for interphase microtubule organization from the centrosome
  Recruitment of NuMA to mitotic centrosomes
  Anchoring of the basal body to the plasma membrane
  COPI-mediated anterograde transport
  COPI-independent Golgi-to-ER retrograde traffic
  AURKA Activation by TPX2
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (6)
Phenotype Name Clinical Significance Source Reference Evidence Score
ASTHMA — GWAS catalog 29083406, 31361310
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE — GWAS catalog 37156999
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE — GWAS catalog 37156999
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS — GWAS catalog 40205036
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SEASONAL ALLERGIC RHINITIS — GWAS catalog 30013184
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (15)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute leukemia Leukemia BEFREE 9539779
★★★★★
★☆☆☆☆
Found in Text Mining only
Allergic rhinitis (disorder) Allergic rhinitis GWASCAT_DG 30013184
★★★★★
★☆☆☆☆
Found in Text Mining only
Choriocarcinoma Choriocarcinoma BEFREE 8782080
★★★★★
★☆☆☆☆
Found in Text Mining only
Hepatoblastoma Hepatoblastoma Pubtator 7784207 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Immunologic Deficiency Syndromes Immunologic Deficiency Syndromes BEFREE 23925294
★★★★★
★☆☆☆☆
Found in Text Mining only
Insulin Resistance Diabetes mellitus, type 2 Pubtator 36750132 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 1321332
★★★★★
★☆☆☆☆
Found in Text Mining only
Liver neoplasms Liver neoplasms BEFREE 1321332
★★★★★
★☆☆☆☆
Found in Text Mining only
Mesothelioma Mesothelioma LHGDN 18303113
★★★★★
★☆☆☆☆
Found in Text Mining only
Mesothelioma Malignant Mesothelioma Pubtator 18303113 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only