Shared-Gene Disease Pairs?
Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.
What do these columns mean?
- Shared genes
- Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
- Similarity score
- Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
- Overlap coefficient
- Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
- P-value / FDR q-value
- Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
- Shared cluster
- Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
| Disease A ⇵ | Disease B ⇵ | Shared genes ⇵ | Similarity score ⇵ | Overlap coefficient ⇵ | P-value ⇵ | FDR q-value ▲ | Shared cluster | |
|---|---|---|---|---|---|---|---|---|
| Prostatic disease | Water intoxication |
1 gene
|
0.333 | 1.000 | 1.30e-4 | 3.91e-4 ✓ sig. | — | |
| Disseminated intravascular coagulation | Prostatic disease |
1 gene
|
0.100 | 1.000 | 5.84e-4 | 1.15e-3 ✓ sig. | — | |
| Headache | Prostatic disease |
1 gene
|
0.091 | 1.000 | 6.49e-4 | 1.24e-3 ✓ sig. | — | |
| Prostatic disease | Tonic-clonic epilepsy |
1 gene
|
0.077 | 1.000 | 7.79e-4 | 1.40e-3 ✓ sig. | — | |
| Hyperkinesia | Prostatic disease |
1 gene
|
0.029 | 1.000 | 2.14e-3 | 3.04e-3 ✓ sig. | — |
0 selected
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Showing 5 of 5 matching pairs, sorted by significance (ascending). Click a column header to sort.