Shared-Gene Disease Pairs?
Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.
What do these columns mean?
- Shared genes
- Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
- Similarity score
- Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
- Overlap coefficient
- Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
- P-value / FDR q-value
- Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
- Shared cluster
- Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
| Disease A ⇵ | Disease B ⇵ | Shared genes ⇵ | Similarity score ⇵ | Overlap coefficient ⇵ | P-value ⇵ | FDR q-value ▼ | Shared cluster | |
|---|---|---|---|---|---|---|---|---|
| Congenital retrognathism | greenberg dysplasia |
1 gene
|
0.143 | 1.000 | 3.90e-4 | 8.67e-4 ✓ sig. | Cluster 280 → | |
| GRHL3-related orofacial clefting | Van der woude syndrome |
1 gene
|
0.143 | 1.000 | 3.90e-4 | 8.67e-4 ✓ sig. | — | |
| Developmental disorder | Diverticulitis |
2 genes
|
0.047 | 0.125 | 3.77e-4 | 8.67e-4 ✓ sig. | — | |
| Internet addiction disorder | Pheochromocytoma |
2 genes
|
0.047 | 0.125 | 3.77e-4 | 8.67e-4 ✓ sig. | — | |
| Esophageal disease | Rotator cuff tear |
2 genes
|
0.045 | 0.133 | 3.79e-4 | 8.67e-4 ✓ sig. | — | |
| Lymphatic malformation | Primary microcephaly |
2 genes
|
0.043 | 0.154 | 3.85e-4 | 8.67e-4 ✓ sig. | — | |
| Congenital diaphragmatic hernia | Syndactyly |
2 genes
|
0.049 | 0.100 | 3.65e-4 | 8.64e-4 ✓ sig. | — | |
| Clonal hematopoiesis | Ileocolitis |
2 genes
Show details |
0.032 | 0.250 | 3.59e-4 | 8.50e-4 ✓ sig. | — | |
| Bell's palsy | Facial nerve disorder |
2 genes
|
0.032 | 0.250 | 3.59e-4 | 8.50e-4 ✓ sig. | — | |
| Pharyngeal disorder | Rosacea |
2 genes
|
0.045 | 0.143 | 3.52e-4 | 8.34e-4 ✓ sig. | — | |
| Hyperaldosteronism | Sick sinus syndrome |
2 genes
|
0.049 | 0.111 | 3.51e-4 | 8.32e-4 ✓ sig. | — | |
| Hyperaldosteronism | Potassium deficiency |
2 genes
|
0.049 | 0.111 | 3.51e-4 | 8.32e-4 ✓ sig. | — | |
| Brain cancer | Small cell lung carcinoma |
2 genes
|
0.021 | 0.400 | 3.41e-4 | 8.10e-4 ✓ sig. | — | |
| Osteonecrosis | Sarcopenia |
2 genes
|
0.041 | 0.182 | 3.39e-4 | 8.04e-4 ✓ sig. | — | |
| Benign prostatic hyperplasia | Testicular carcinoma |
3 genes
|
0.032 | 0.086 | 3.37e-4 | 7.99e-4 ✓ sig. | — | |
| Brachydactyly | Cryptorchidism |
2 genes
|
0.050 | 0.100 | 3.32e-4 | 7.87e-4 ✓ sig. | — | |
| Epidermolysis bullosa | Fraser syndrome |
2 genes
|
0.050 | 0.100 | 3.32e-4 | 7.87e-4 ✓ sig. | — | |
| Hereditary parkinson disease | Secondary parkinson disease |
2 genes
|
0.048 | 0.133 | 3.30e-4 | 7.83e-4 ✓ sig. | Cluster 256 → | |
| Multinodular goiter | Urinary system disease |
2 genes
|
0.048 | 0.133 | 3.30e-4 | 7.83e-4 ✓ sig. | — | |
| Developmental dysplasia of the hip | Multiple system atrophy |
2 genes
|
0.047 | 0.143 | 3.29e-4 | 7.81e-4 ✓ sig. | — | |
| Appendicitis | Testicular disease |
2 genes
|
0.047 | 0.143 | 3.29e-4 | 7.81e-4 ✓ sig. | — | |
| 16q24.3 microdeletion syndrome | Conductive hearing loss |
1 gene
|
0.167 | 1.000 | 3.25e-4 | 7.71e-4 ✓ sig. | — | |
| Abcd syndrome | Kleins syndrome |
1 gene
|
0.167 | 1.000 | 3.25e-4 | 7.71e-4 ✓ sig. | — | |
| Acces syndrome | Aplasia cutis congenita |
1 gene
|
0.167 | 1.000 | 3.25e-4 | 7.71e-4 ✓ sig. | — | |
| Acral self-healing collodion baby | Vitamin a deficiency |
1 gene
|
0.167 | 1.000 | 3.25e-4 | 7.71e-4 ✓ sig. | — |
0 selected
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Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.