Shared-Gene Disease Pairs?
Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.
What do these columns mean?
- Shared genes
- Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
- Similarity score
- Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
- Overlap coefficient
- Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
- P-value / FDR q-value
- Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
- Shared cluster
- Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
| Disease A ⇵ | Disease B ⇵ | Shared genes ⇵ | Similarity score ⇵ | Overlap coefficient ⇵ | P-value ⇵ | FDR q-value ▲ | Shared cluster | |
|---|---|---|---|---|---|---|---|---|
| Hyperopia | ITPKB deficiency |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| Brachial plexus neuritis | Hyperopia |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| congenital myasthenic syndrome 8 | Hyperopia |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| Chondrodysplasia-difference of sex development syndrome | Hyperopia |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| Chondrodysplasia-pseudohypohermaphroditism syndrome | Hyperopia |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| Hyperopia | nephrotic syndrome 14 |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| Hyperopia | Neuralgic amyotrophy |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| hermansky-pudlak syndrome 8 | Hyperopia |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| Hyperopia | Hypochromic sideroblastic anemia |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| Hyperopia | renal hypomagnesemia 2 |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| Hyperopia | Primary hypomagnesemia with hypocalciuria |
1 gene
|
0.013 | 1.000 | 5.13e-3 | 6.28e-3 ✓ sig. | — | |
| Machado-joseph disease | Omenn syndrome |
1 gene
|
0.056 | 0.125 | 5.18e-3 | 6.34e-3 ✓ sig. | — | |
| Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency | Mitochondrial encephalomyopathy |
1 gene
|
0.048 | 0.200 | 5.19e-3 | 6.34e-3 ✓ sig. | Cluster 50 → | |
| Developmental disorder | Dyshidrosis |
1 gene
Show details
DLG2(1)
|
0.048 | 0.200 | 5.19e-3 | 6.34e-3 ✓ sig. | — | |
| Dental enamel hypoplasia | Dyshidrosis |
1 gene
Show details
PTPRD(1)
|
0.048 | 0.200 | 5.19e-3 | 6.34e-3 ✓ sig. | — | |
| Aneuploidy | Lymphedema |
1 gene
|
0.048 | 0.200 | 5.19e-3 | 6.34e-3 ✓ sig. | — | |
| Congenital heart malformation | Microform holoprosencephaly |
1 gene
|
0.048 | 0.200 | 5.19e-3 | 6.34e-3 ✓ sig. | Cluster 96 → | |
| Bulimia | Greither disease |
1 gene
|
0.042 | 0.250 | 5.19e-3 | 6.34e-3 ✓ sig. | — | |
| Dandy-walker syndrome | Ritscher-schinzler syndrome |
1 gene
|
0.042 | 0.250 | 5.19e-3 | 6.34e-3 ✓ sig. | — | |
| Situs inversus | Visceral heterotaxy |
1 gene
|
0.042 | 0.250 | 5.19e-3 | 6.34e-3 ✓ sig. | Cluster 46 → | |
| Degenerative disorder | Masp2 deficiency |
1 gene
Show details
TARDBP(1)
|
0.024 | 0.500 | 5.19e-3 | 6.34e-3 ✓ sig. | — | |
| Degenerative disorder | Seborrhea-like dermatitis with psoriasiform elements |
1 gene
Show details
TBCD(1)
|
0.024 | 0.500 | 5.19e-3 | 6.34e-3 ✓ sig. | — | |
| Catel-manzke syndrome | Degenerative disorder |
1 gene
Show details
KYNU(1)
|
0.024 | 0.500 | 5.19e-3 | 6.34e-3 ✓ sig. | — | |
| Chylomicron retention disease | Nephronophthisis |
1 gene
|
0.024 | 0.500 | 5.19e-3 | 6.34e-3 ✓ sig. | — | |
| Hyperlipoproteinemia | Myoadenylate deaminase deficiency |
1 gene
|
0.024 | 0.500 | 5.19e-3 | 6.34e-3 ✓ sig. | — |
0 selected
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Showing 25 of 20813 pairs, sorted by significance (ascending). Click a column header to sort.