Subtype of: Thyroid neoplasms

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
thyroid gland undifferentiated (anaplastic) carcinoma	MONDO_0006468	PLCG1	Unknown	33428730	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	33428730	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PMS2	Unknown	29615459	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLD1	Unknown	29615459 33428730	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	29615459 28481359 26878173	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PPARG	Unknown	12161538 12970322 24613930 12170088	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PRDM1	Unknown	28481359 26878173	Open Targets	Regulation of TP53 Expression
		PREX2	Unknown	29615459	Open Targets	Regulation of PTEN stability and activity
		PRKAR1A	Unknown	9516913 12203783	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PSIP1	Unknown	33428730	Open Targets	Viral life cycle - HIV-1 Integration of provirus 2-LTR circle formation +4 more
		PTCH1	Unknown	25295501 29615459 26878173	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	28351340 24423316 29615459 25862857 26878173 17317825 25940539 28481359 27785980 28423545	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPRK	Unknown	33428730	Open Targets	EGFR downregulation
		PTPRT	Unknown	26878173	Open Targets	—
		RAC1	Unknown	29615459 28481359 26878173	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +89 more
		RAD50	Unknown	29615459 26878173	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51C	Unknown	33428730	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RAF1	Unknown	29615459	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RANBP2	Unknown	29615459	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RB1	Unknown	28351340 29615459 25862857 26878173 31621921 28481359	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	29615459 28481359 26878173	Open Targets	—
		RBM15	Unknown	33428730	Open Targets	—
		RECQL4	Unknown	28481359 26878173	Open Targets	—
		RET	Unknown	21173509 9516913 28351340 10951397 16015630 19055826 24613930 20840674 31766881 28423545	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RMI2	Unknown	26878173	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		RNF43	Unknown	29615459	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROCK1	Unknown	31621921	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway +25 more
		ROS1	Unknown	26878173	Open Targets	—
		RPL5	Unknown	27797976	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RUNX1T1	Unknown	29615459	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		SDHA	Unknown	29615459	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SETD2	Unknown	29615459 28481359 26878173	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SF3B1	Unknown	26878173 33428730	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SFPQ	Unknown	31621921	Open Targets	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis
		SH2B3	Unknown	29615459	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SMAD2	Unknown	29615459	Open Targets	Cell cycle Endocytosis Cellular senescence +30 more
		SMAD3	Unknown	26878173	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	28351340	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	25295501 27797976 26878173 29615459	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	29615459 28351340 28481359 26878173 34057693	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SMO	Unknown	29615459 28351340	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SNX29	Unknown	33428730	Open Targets	—
		SOCS1	Unknown	26878173	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SPEN	Unknown	29615459 25295501 26878173	Open Targets	Notch signaling pathway
		SPOP	Unknown	25295501	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		SRC	Unknown	28481359 26878173	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more
		SS18L1	Unknown	25295501	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		STAG2	Unknown	29615459	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STK11	Unknown	29615459 28351340 28481359 26878173	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STRN	Unknown	24475247 24613930	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more

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Thyroid gland undifferentiated (anaplastic) carcinoma

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