Subtype of: Thyroid neoplasms

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
thyroid gland undifferentiated (anaplastic) carcinoma	MONDO_0006468	LZTR1	Unknown	29615459 25295501	Open Targets	—
		MACC1	Unknown	25295501	Open Targets	—
		MAP2K1	Unknown	29615459	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP2K4	Unknown	28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	29615459	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	26878173	Open Targets	MAPK signaling pathway
		MAPK1	Unknown	26878173	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MED12	Unknown	29615459 26878173	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEN1	Unknown	29615459 28481359 26878173	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	28351340 19487299 29615459 25862857 25940539 27785980	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MLH1	Unknown	29615459 28481359 26878173	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MSH2	Unknown	29615459 25862857 28481359 26878173 31621921	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	29615459 26878173 33428730	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	25295501 30918329 29615459 26878173 25940539 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC16	Unknown	25295501 33428730	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	25295501 33428730	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC6	Unknown	25295501	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUTYH	Unknown	29615459 26878173	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYH11	Unknown	25295501	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		NAB2	Unknown	25295501	Open Targets	NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
		NACA	Unknown	25295501	Open Targets	Parathyroid hormone synthesis, secretion and action
		NBN	Unknown	29615459 26878173	Open Targets	Homologous recombination Cellular senescence DNA Damage/Telomere Stress Induced Senescence +13 more
		NCOA4	Unknown	20840674 21173509 9516913 16015630 24613930	Open Targets	Ferroptosis Pathways in cancer Thyroid cancer
		NCOR1	Unknown	29615459 33428730	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NCOR2	Unknown	25295501 31621921	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NF1	Unknown	29615459 25862857 28481359 26878173 33428730	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NF2	Unknown	29615459 28481359 26878173	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NFATC2	Unknown	25295501	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis +24 more
		NFE2L2	Unknown	29615459	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NKX2-1	Unknown	26878173	Open Targets	—
		NOTCH1	Unknown	29615459 34057693 28481359 26878173	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	29615459 26878173 33428730	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NRAS	Unknown	17638058 12947056 28351340 33428730 19487299 24423316 29615459 2648253 26878173 17317825 18070147 14508525 28781658 34972706 19706758 7704243 38602501 37760447 28481359 27785980 28423545	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NSD1	Unknown	28481359 26878173	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NSD3	Unknown	25295501 33428730	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTRK1	Unknown	29615459	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK3	Unknown	29615459 26878173 33428730	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUP98	Unknown	33428730	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		PALB2	Unknown	29615459	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PATZ1	Unknown	33428730	Open Targets	—
		PAX8	Unknown	12161538 12970322 24613930 12170088	Open Targets	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PBRM1	Unknown	29615459 28481359 26878173	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PCBP1	Unknown	33428730	Open Targets	Spliceosome Ferroptosis Cytosolic DNA-sensing pathway +2 more
		PDE4DIP	Unknown	33428730	Open Targets	—
		PDGFRA	Unknown	28481359 26878173	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	25295501 29615459 26878173 33428730	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PIK3CA	Unknown	28631713 16288007 28351340 33428730 19487299 24423316 29615459 26878173 17317825 27785980 19706758 27797976 28481359 22696596 28423545	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	25295501 25940539	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R1	Unknown	29615459 25940539	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PIK3R2	Unknown	29615459 28481359 26878173	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more

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Thyroid gland undifferentiated (anaplastic) carcinoma

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