Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	MUTYH	Unknown	22810696 28481359 31660073	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYB	Unknown	26109429 31660073 29937994	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		MYC	Unknown	24755471 33262464 28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYCL	Unknown	33262464 28481359	Open Targets	—
		MYCN	Unknown	28481359 26416732 25344691	Open Targets	Transcriptional misregulation in cancer
		MYD88	Unknown	22810696 29967250	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		MYH11	Unknown	22810696 26416732 33262464 25344691 31660073	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		MYH9	Unknown	22810696 33262464 25344691 25957691 29967250	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		MYO5A	Unknown	22810696 33262464 29937994 26416732 31660073 25344691 24755471	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		MYOD1	Unknown	30038269 29316426 28481359	Open Targets	Spinocerebellar ataxia Myogenesis
		N4BP2	Unknown	22810696 31660073 33262464 29937994	Open Targets	—
		NAB2	Unknown	22810696 33262464	Open Targets	NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
		NACA	Unknown	33262464 31660073	Open Targets	Parathyroid hormone synthesis, secretion and action
		NBEA	Unknown	22810696 30038269 33262464 29937994 26416732 25344691 24755471 17932254	Open Targets	—
		NBN	Unknown	33262464 29937994 26416732 29316426 26109429 28481359	Open Targets	Homologous recombination Cellular senescence DNA Damage/Telomere Stress Induced Senescence +13 more
		NCKIPSD	Unknown	26416732 26764183 31660073	Open Targets	Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis
		NCOA1	Unknown	24755471 33262464	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer +18 more
		NCOA2	Unknown	22810696	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NCOR1	Unknown	22810696 33262464 29937994 26416732 31660073 24755471 28481359	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NCOR2	Unknown	30038269 33262464 26416732 25957691 31660073 30239619 25344691 24755471 26764183	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NDRG1	Unknown	24755471 26416732 33262464 31660073	Open Targets	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
		NF1	Unknown	22810696 29967250 33262464 29937994 26416732 29316426 28465371 31660073 16959974 24755471 26764183 28481359 31226844	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NF2	Unknown	26416732 29316426 28481359 33262464	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NFATC2	Unknown	22810696 33262464	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis +24 more
		NFE2L2	Unknown	22810696 33262464 28481359	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFIB	Unknown	22810696 33262464	Open Targets	—
		NFKB2	Unknown	22810696 33262464 29967250	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more
		NFKBIE	Unknown	24755471 25344691	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway +6 more
		NIN	Unknown	22810696 24755471 26416732 33262464 29967250	Open Targets	—
		NKX2-1	Unknown	29316426 33262464 28481359	Open Targets	—
		NONO	Unknown	33262464	Open Targets	—
		NOTCH1	Unknown	33262464 26416732 29316426 27756406 31660073 25344691 28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	22810696 33262464 26416732 29316426 31660073 30239619 25344691 24755471 26764183 28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NPM1	Unknown	29967250 33262464 25344691	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NR2F2	Unknown	31660073 30239619 33262464 29937994	Open Targets	—
		NR4A3	Unknown	22810696 24755471 26416732 31660073	Open Targets	Transcriptional misregulation in cancer Nuclear Receptor transcription pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
		NRAS	Unknown	30038269 21704278 26416732 28120820 27121310 26134512 21726664 20736745 22810696 23274911 37262393 31660073 27929064 27756406 25957691 22392911 22617127 25344691 26968814 33262464 23400451 22586653 28978093 22427190 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NRG1	Unknown	22810696 33262464 31660073 30239619 25344691 26764183	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD1	Unknown	22810696 30038269 33262464 26416732 27247954 29316426 25344691 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NSD2	Unknown	26109429 33262464 25344691 31660073	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		NSD3	Unknown	29316426 33262464 29937994 31660073	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NT5C2	Unknown	22810696 33262464 29937994	Open Targets	Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism +4 more
		NTHL1	Unknown	26109429 25344691	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine +3 more
		NTRK1	Unknown	29967250 30038269 33262464 26416732 29316426 31660073 26109429 25344691 26764183 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	22810696 33262464 28481359 29967250	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NTRK3	Unknown	22810696 33262464 29937994 26416732 29316426 31660073 24755471 28481359	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	33262464 29937994 31660073 25344691 24755471 26764183	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUP214	Unknown	26109429 26416732 26764183 31660073 29937994	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		NUP98	Unknown	30038269 33262464 31660073	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		NUTM1	Unknown	22810696 26416732	Open Targets	—

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Rectum adenocarcinoma

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