Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	HRAS	Unknown	28978093 28481359 31660073	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		HSP90AA1	Unknown	22810696	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		HSP90AB1	Unknown	22810696 25344691	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IDH1	Unknown	29316426 30239619 26416732 28481359 29967250	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	33262464 28481359	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IGF2BP2	Unknown	33262464	Open Targets	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IKBKB	Unknown	26416732 33262464	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IKZF1	Unknown	29967250 33262464 26416732 29316426 30239619 28481359	Open Targets	—
		IKZF3	Unknown	22810696 26416732 33262464 27612425	Open Targets	—
		IL21R	Unknown	22810696 26109429 26416732	Open Targets	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL6ST	Unknown	22810696 24755471 26109429 33262464 31660073	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		IL7R	Unknown	23069254 26416732 33262464 28481359	Open Targets	Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway +7 more
		IRF4	Unknown	30239619 29316426 28481359	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		IRS4	Unknown	22810696 26416732 25344691 31660073	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		ISX	Unknown	22810696 26764183	Open Targets	—
		ITGAV	Unknown	22810696 24755471 33262464 26764183 31660073	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		ITK	Unknown	22810696 30239619 33262464	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	22810696 33262464 26416732 29316426 31660073 24755471 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	29967250 22810696 33262464 26416732 29316426 26109429 25344691 25617745 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	29967250 27756406 28481359 31660073	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		JUN	Unknown	31660073 26416732 28481359 27612425	Open Targets	Endocrine resistance MAPK signaling pathway ErbB signaling pathway +63 more
		KAT6A	Unknown	30038269 26416732 33262464 25344691	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT6B	Unknown	22810696 31660073 33262464 25344691 29937994	Open Targets	HATs acetylate histones
		KAT7	Unknown	22810696 24755471 33262464	Open Targets	HATs acetylate histones
		KCNJ5	Unknown	33262464	Open Targets	Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse +8 more
		KDM5A	Unknown	22810696 33262464 26416732 29316426 25344691 28481359	Open Targets	HDMs demethylate histones
		KDM5C	Unknown	30038269 28481359 29316426 25344691 33262464	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	28481359 31660073 25344691 28551381 29937994	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	29967250 33262464 29937994 26416732 27756406 31660073 26109429 16959974 24755471 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KEAP1	Unknown	29316426 33262464 28481359 27612425	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIAA1549	Unknown	22810696 30038269 33262464 29937994 25957691 25344691 26764183	Open Targets	Signaling by BRAF and RAF fusions
		KIF5B	Unknown	22810696 24755471 29937994 27612425	Open Targets	Endocytosis Dopaminergic synapse Motor proteins +12 more
		KIT	Unknown	22810696 33262464 26416732 27756406 31660073 25344691 26968814 28915719 25617745 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KLF4	Unknown	26416732 28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KLF6	Unknown	22810696 33262464	Open Targets	—
		KMT2A	Unknown	22810696 29967250 33262464 26416732 29316426 31660073 26109429 28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	29967250 22810696 33262464 29937994 27612425 26416732 29316426 31660073 30239619 25344691 16959974 24755471 26764183 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	22810696 33262464 26416732 29316426 31660073 30239619 25344691 28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	22810696 30038269 26416732 33262464 24755471	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KNSTRN	Unknown	22810696 33262464 31660073	Open Targets	—
		KRAS	Unknown	26650777 21704278 12039935 21474505 22586484 29069792 22593440 22259183 19223544 21458303 36212424 23456389 16959974 18544172 21837511 27929064 16699497 19679059 27756406 22392911 22617127 26968814 24518836 21536390 8486427 19832985 20979647 24470207 23730514 26536055 31226844 2203688 22282307 11106095 14688025 23125007 24755471 21726664 21445971 22722830 21103049 1627381 31660073 12093899 21369707 28936923 28915719 8621253 12012008 8033106 18757341 19913317 3587348 20361188 19527492 20888703 19574674 9097993 21659424 8895682 23009572 37113399 28978093 28548127 8039618 8160776 9568504 18022911 19903786 22722843 18602395 23226389 30038269 10510729 23761841 26416732 29316426 20049979 28120820 27121310 19686742 1566048 22252179 1453686 9075750 11435722 24519090 22089345 10362137 21901162 29937994 19637313 9036876 14633673 25344691 20924129 22586653 24841357 30239619 23569465 8514605 22672749 9823556 24943349 27612425 7890240 26134512 27155048 25694286 22810696 29967250 10025877 19731079 11231481 22537608 26109429 10956407 31400926 23617638 10884918 7731696 26764183 20176655 25248721 28551381 37256170 33262464 19026650 22740969 9018769 21029218 21603900 11289147 28481359 17932254	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	24755471 31660073	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	26416732 25344691	Open Targets	—
		LASP1	Unknown	22810696 30038269 25344691	Open Targets	—
		LATS1	Unknown	30038269 30239619 33262464 28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	22810696 29937994 26416732 31660073 25344691 28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCK	Unknown	33262464	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Natural killer cell mediated cytotoxicity +27 more
		LCP1	Unknown	22810696 26416732 26764183	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LEF1	Unknown	24755471 33262464 17267311 31660073	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		LHFPL6	Unknown	33262464	Open Targets	—

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Rectum adenocarcinoma

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