Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	LIFR	Unknown	22810696 33262464 25344691 29937994 31660073	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more
		LMNA	Unknown	22810696 33262464 29967250	Open Targets	Apoptosis Cytoskeleton in muscle cells Hypertrophic cardiomyopathy +8 more
		LMO1	Unknown	30038269 33262464 28481359	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		LOC100506403	Unknown	30038269 33262464 26416732 27247954 31660073 28481359	Open Targets	—
		LOC105376156	Unknown	29316426 30239619 26416732 28481359 31660073	Open Targets	—
		LOC124905021	Unknown	22810696 31660073 26416732 17367471 33262464	Open Targets	—
		LPP	Unknown	33262464	Open Targets	—
		LRIG3	Unknown	22810696 26416732 33262464 29937994 31660073	Open Targets	—
		LRP1B	Unknown	22810696 29967250 33262464 27612425 26416732 28465371 25957691 31660073 26109429 24755471 26764183	Open Targets	—
		LSM14A	Unknown	22810696 25957691	Open Targets	—
		LYN	Unknown	31660073	Open Targets	Chemokine signaling pathway NF-kappa B signaling pathway Platelet activation +36 more
		LZTR1	Unknown	26416732 33262464 31660073	Open Targets	—
		MACC1	Unknown	22810696 33262464 26416732 31660073 30239619 25344691	Open Targets	—
		MALT1	Unknown	33262464 28481359	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		MAML2	Unknown	22810696 24755471 26416732 29937994	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP2K1	Unknown	27612425 29937994 26416732 31660073 25344691 27155048 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP2K2	Unknown	22810696 26416732 29316426 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MAP2K4	Unknown	29967250 29937994 29316426 28465371 31660073 24755471 28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	22810696 30038269 33262464 26416732 29316426 31660073 24755471 28481359	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	22810696 33262464 27612425 29316426 25957691 31660073 24755471 28481359	Open Targets	MAPK signaling pathway
		MAPK1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MAX	Unknown	33262464 26416732 29316426 31660073 25344691 26764183	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MB21D2	Unknown	24755471	Open Targets	—
		MDM2	Unknown	26416732 33262464 28481359 31660073	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		MDM4	Unknown	29316426 25344691 29937994 27612425	Open Targets	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MECOM	Unknown	22810696 31660073	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MED12	Unknown	22810696 29967250 33262464 27612425 26416732 29316426 31660073 25344691 28481359	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEN1	Unknown	22810696 26416732 26764183 25344691 28481359	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	22810696 33262464 26416732 29316426 27756406 31660073 25617745 26764183 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MGMT	Unknown	22810696	Open Targets	MGMT-mediated DNA damage reversal
		MITF	Unknown	22810696 33262464 24943349 28481359	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLF1	Unknown	22810696 31660073	Open Targets	Transcriptional misregulation in cancer
		MLH1	Unknown	29967250 33262464 21157497 26764183 26416732 31660073 36212424 28978093 25194673 25344691 20473912 28481359	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT1	Unknown	33262464	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MLLT10	Unknown	22810696 30239619 29967250	Open Targets	—
		MLLT3	Unknown	33262464 25344691	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MN1	Unknown	22810696 26416732 33262464	Open Targets	—
		MNX1	Unknown	33262464	Open Targets	Maturity onset diabetes of the young
		MPL	Unknown	24755471 26416732 28481359 30038269	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MRTFA	Unknown	33262464 31660073	Open Targets	SUMOylation of transcription cofactors RHO GTPases Activate Formins
		MSH2	Unknown	22810696 29937994 26416732 29316426 25194673 28978093 24755471 10793088 28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	22810696 33262464 29937994 26416732 29316426 31660073 19503063 24755471 26764183 28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MSI2	Unknown	26416732 26764183 25344691	Open Targets	mRNA surveillance pathway
		MSN	Unknown	22810696 30239619 33262464 25957691 31660073	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +4 more
		MTCP1	Unknown	33262464 17932254	Open Targets	PI3K-Akt signaling pathway
		MTOR	Unknown	22810696 30038269 29937994 26416732 29316426 31660073 30239619 24755471 26764183 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC1	Unknown	26764183	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +4 more
		MUC16	Unknown	22810696 30038269 33262464 29937994 27612425 26416732 25957691 31660073 25344691 24755471 26764183	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	22810696 33262464 27612425 29937994 26416732 31660073 26109429 30239619 25344691 24755471	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC6	Unknown	22810696 33262464 25344691 31660073	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more

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Rectum adenocarcinoma

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