Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
plasma cell myeloma	MONDO_0009693	FLT4	Unknown	35045690 30545397 24434212	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FNBP1	Unknown	30545397 24434212	Open Targets	Shigellosis Clathrin-mediated endocytosis
		FOXA1	Unknown	35045690 24434212	Open Targets	Estrogen-dependent gene expression
		FOXO1	Unknown	30545397 24434212	Open Targets	FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway +23 more
		FOXO3	Unknown	24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway FoxO signaling pathway +26 more
		FOXO4	Unknown	30545397 24434212	Open Targets	Ras signaling pathway FoxO signaling pathway Shigellosis +7 more
		FOXP1	Unknown	24434212	Open Targets	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		FOXR1	Unknown	24434212	Open Targets	—
		FUBP1	Unknown	30545397 24434212	Open Targets	—
		FUS	Unknown	30545397 24434212	Open Targets	mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis +3 more
		GAS7	Unknown	24434212	Open Targets	—
		GATA1	Unknown	38019014	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA2	Unknown	30545397	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GATA3	Unknown	35045690 24434212	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action +6 more
		GLI1	Unknown	23396385	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GMPS	Unknown	24434212	Open Targets	Purine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
		GNA11	Unknown	24434212	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling +23 more
		GNAQ	Unknown	24434212	Open Targets	Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +52 more
		GNAS	Unknown	35045690 30545397 29386642 22573403 24434212	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GOLGA5	Unknown	30545397 24434212	Open Targets	Intra-Golgi traffic
		GPC3	Unknown	24434212	Open Targets	Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis +9 more
		GPC5	Unknown	24434212	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPHN	Unknown	30545397 24434212	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		GRIN2A	Unknown	35045690 30545397 24434212	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		GRM3	Unknown	35045690 30545397 24434212	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GSK3B	Unknown	24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		GTF2I	Unknown	24434212	Open Targets	Basal transcription factors cGMP-PKG signaling pathway
		H3-3A	Unknown	24434212	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H3-3B	Unknown	30545397	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		H3C2	Unknown	24434212	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		HERPUD1	Unknown	30545397 24434212	Open Targets	Protein processing in endoplasmic reticulum ATF4 activates genes in response to endoplasmic reticulum stress
		HEY1	Unknown	30545397	Open Targets	Notch signaling pathway Human papillomavirus infection Pathways in cancer +4 more
		HGF	Unknown	30545397 24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIF1A	Unknown	30545397 24434212	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HIP1	Unknown	30545397 24434212	Open Targets	Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis
		HLA-A	Unknown	29563506 22573403 24434212	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HLF	Unknown	24434212	Open Targets	—
		HMGA2	Unknown	30545397 24434212	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		HNF1A	Unknown	30545397 24434212	Open Targets	Maturity onset diabetes of the young
		HNRNPA2B1	Unknown	35045690 24434212	Open Targets	Amyotrophic lateral sclerosis mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA +1 more
		HOOK3	Unknown	30545397 24434212	Open Targets	Motor proteins
		HOXA9	Unknown	29563506 24434212	Open Targets	Transcriptional misregulation in cancer
		HOXC11	Unknown	24434212	Open Targets	—
		HOXC13	Unknown	35045690	Open Targets	—
		HOXD13	Unknown	24434212	Open Targets	—
		HRAS	Unknown	14616967 24434212 12068308 30545397 12569357 36606310	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		HSP90AA1	Unknown	24434212	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		HSP90AB1	Unknown	24434212	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IDH1	Unknown	37452600 29563506 26918361 24434212 19117336	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	30545397 24434212	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more

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Plasma cell myeloma

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