Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
plasma cell myeloma	MONDO_0009693	TOP1	Unknown	30545397 24434212	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	1461658 24434212 8417784 29563506 22573403 29386642 23044976 8321049 36251745 23856246 1390218 37452600 23396385 35045690 35770320 24335104 26918361 25302557 25743686 8590778 30545397 35847743 17215851 8182933	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	30545397 36251745 29563506 24434212	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPM3	Unknown	24434212	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPM4	Unknown	36251745 24434212	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +5 more
		TPR	Unknown	35045690 30545397 24434212	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRAF7	Unknown	30545397 24434212	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM24	Unknown	30545397 24434212	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIM27	Unknown	30545397 24434212	Open Targets	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
		TRIM33	Unknown	30545397 24434212	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRIP11	Unknown	30545397 24434212	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	36251745 30545397 35045690 24434212	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC1	Unknown	30545397 24434212	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	35045690 30545397 24434212	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	30545397 24434212	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		U2AF1	Unknown	30545397 23856246 24434212	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		UBR5	Unknown	35045690 30545397 24434212	Open Targets	Ubiquitin mediated proteolysis
		USP44	Unknown	24434212	Open Targets	Ub-specific processing proteases
		USP6	Unknown	25794135 30545397 24434212	Open Targets	—
		USP8	Unknown	35045690 30545397 24434212	Open Targets	Mitophagy - animal Endocytosis Cushing syndrome +4 more
		USP9X	Unknown	35045690 30545397 24434212	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		VAV1	Unknown	24434212	Open Targets	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +30 more
		VTI1A	Unknown	24434212	Open Targets	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		WDCP	Unknown	35045690 24434212	Open Targets	—
		WIF1	Unknown	35045690 24434212	Open Targets	Wnt signaling pathway
		WNK2	Unknown	36251745 30545397 24434212	Open Targets	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		WRN	Unknown	30545397 24434212	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more
		WT1	Unknown	24434212	Open Targets	Transcriptional misregulation in cancer
		WWTR1	Unknown	30545397 24434212	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo +5 more
		XPA	Unknown	30545397 24434212	Open Targets	Platinum drug resistance Nucleotide excision repair Formation of Incision Complex in GG-NER +3 more
		XPC	Unknown	30545397 24434212	Open Targets	Nucleotide excision repair SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER +1 more
		XPO1	Unknown	30545397 24434212	Open Targets	Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 +15 more
		YAP1	Unknown	30545397 29563506 24434212	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 +5 more
		YWHAE	Unknown	24434212	Open Targets	Cell cycle Oocyte meiosis PI3K-Akt signaling pathway +22 more
		ZBTB16	Unknown	30545397 23396385 24434212	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia +2 more
		ZCCHC8	Unknown	35045690	Open Targets	—
		ZEB1	Unknown	30545397 35045690 24434212	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer +1 more
		ZFHX3	Unknown	30545397 35045690 29563506 23856246 24434212	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZMYM2	Unknown	30545397 24434212	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
		ZMYM3	Unknown	30545397 24434212	Open Targets	—
		ZNF331	Unknown	30545397 24434212	Open Targets	Generic Transcription Pathway
		ZNF384	Unknown	35045690 24434212	Open Targets	—
		ZNF429	Unknown	35045690 24434212	Open Targets	Generic Transcription Pathway
		ZNF479	Unknown	30545397 24434212	Open Targets	Generic Transcription Pathway
		ZNF521	Unknown	35045690 30545397 24434212	Open Targets	—
		ZNRF3	Unknown	30545397 24434212	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination
		ZRSR2	Unknown	30545397 24434212	Open Targets	mRNA Splicing - Minor Pathway

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Plasma cell myeloma

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