Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
plasma cell myeloma	MONDO_0009693	SNX29	Unknown	35045690 30545397 24434212	Open Targets	—
		SOCS1	Unknown	30545397 35045690 29563506 24434212	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SOS1	Unknown	35045690 24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SOX2	Unknown	24434212	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SPECC1	Unknown	36251745 30545397	Open Targets	—
		SPEN	Unknown	30545397 35045690 23856246 25302557 24434212	Open Targets	Notch signaling pathway
		SPOP	Unknown	30545397 29563506 24434212	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		SRC	Unknown	24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more
		SRGAP3	Unknown	24434212	Open Targets	Axon guidance Rho GTPase cycle
		SRSF2	Unknown	36251745 29563506	Open Targets	Spliceosome Herpes simplex virus 1 infection Transport of Mature mRNA derived from an Intron-Containing Transcript +4 more
		SS18	Unknown	35045690 24434212	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		SS18L1	Unknown	30545397	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		STAG1	Unknown	35045690 30545397 24434212	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAG2	Unknown	29386642 24434212	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAT3	Unknown	30545397 29563506 29386642 26918361 24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STAT5B	Unknown	24434212	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more
		STAT6	Unknown	30545397 24434212	Open Targets	Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation +7 more
		STIL	Unknown	30545397 24434212	Open Targets	—
		STK11	Unknown	35045690 24335104 24434212	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STRN	Unknown	35045690 30545397 24434212	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		SUB1	Unknown	24434212	Open Targets	—
		SUFU	Unknown	30545397 24434212	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		SUZ12	Unknown	24434212	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +5 more
		SYK	Unknown	35045690 24434212	Open Targets	NF-kappa B signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway +30 more
		TAL1	Unknown	24434212	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		TBL1XR1	Unknown	24434212	Open Targets	Wnt signaling pathway RORA activates gene expression PPARA activates gene expression +11 more
		TBX3	Unknown	24434212	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TCEA1	Unknown	24434212	Open Targets	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex +5 more
		TCF12	Unknown	30545397 24434212	Open Targets	Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription
		TCF3	Unknown	30545397 29563506 24434212	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TCF7L2	Unknown	35045690 30545397 24434212	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TCL1A	Unknown	30545397 22573403 24434212	Open Targets	PI3K-Akt signaling pathway
		TEC	Unknown	35045690 30545397 24434212	Open Targets	Osteoclast differentiation T cell receptor signaling pathway Signaling by SCF-KIT +2 more
		TENT5C	Unknown	25743686 24434212 30545397 35045690 21994415 35770320 29563506 22573403 37452600 23396385 26918361 26456599	Open Targets	—
		TERT	Unknown	30545397 35045690 24434212	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TET1	Unknown	36251745 35045690 24434212	Open Targets	—
		TET2	Unknown	35045690 30545397 29386642 24434212 35380239	Open Targets	—
		TFE3	Unknown	35045690 30545397 24434212	Open Targets	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma
		TFEB	Unknown	35045690 24434212	Open Targets	Calcium signaling pathway Mitophagy - animal
		TFG	Unknown	24434212	Open Targets	Pathways in cancer Thyroid cancer COPII-mediated vesicle transport
		TFPT	Unknown	24434212	Open Targets	ATP-dependent chromatin remodeling UCH proteinases DNA Damage Recognition in GG-NER
		TFRC	Unknown	24434212	Open Targets	Virion - Lassa virus and SFTS virus HIF-1 signaling pathway Endocytosis +8 more
		TGFBR2	Unknown	23396385 24434212	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		THRAP3	Unknown	35045690 29563506 24434212	Open Targets	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation
		TMEM127	Unknown	24434212	Open Targets	—
		TMSB4X	Unknown	30545397 29563506 24434212	Open Targets	Regulation of actin cytoskeleton Platelet degranulation
		TNC	Unknown	23396385 24434212	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TNFAIP3	Unknown	30545397 24434212	Open Targets	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
		TNFRSF17	Unknown	35045690 24434212	Open Targets	Cytokine-cytokine receptor interaction Intestinal immune network for IgA production TNFs bind their physiological receptors
		TNRC18	Unknown	35045690 30545397 24434212 36251745	Open Targets	—

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Plasma cell myeloma

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