Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
plasma cell myeloma	MONDO_0009693	ERBB2	Unknown	35045690 30545397 24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	23396385 22573403 24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERBB4	Unknown	35045690 24434212	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERC1	Unknown	30545397 24434212	Open Targets	NF-kappa B signaling pathway
		ERCC2	Unknown	35045690 30545397 24434212	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC3	Unknown	25794135 36251745 35045690 24434212	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC4	Unknown	24434212	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		ERCC5	Unknown	24434212	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		ERG	Unknown	24434212	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ESR1	Unknown	30545397 29563506 24434212	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		ETNK1	Unknown	35045690 30545397 23396385 24434212	Open Targets	Glycerophospholipid metabolism Metabolic pathways Synthesis of PE
		ETV1	Unknown	30545397 23396385 24434212	Open Targets	Transcriptional misregulation in cancer
		ETV4	Unknown	35045690 30545397	Open Targets	Transcriptional misregulation in cancer MAPK6/MAPK4 signaling
		ETV5	Unknown	35045690 30545397 24434212	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ETV6	Unknown	35045690 24434212	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EWSR1	Unknown	35045690 30545397 24434212	Open Targets	Transcriptional misregulation in cancer
		EXT1	Unknown	30545397 24434212	Open Targets	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis +2 more
		EXT2	Unknown	30545397 24434212	Open Targets	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis +2 more
		EZH2	Unknown	30545397 24434212	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		EZR	Unknown	24434212	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +6 more
		FAM135B	Unknown	35045690 24434212	Open Targets	—
		FAM47C	Unknown	24434212	Open Targets	—
		FANCA	Unknown	35045690 30545397 22573403 24434212	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCD2	Unknown	30545397 35045690 24434212	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FANCE	Unknown	35045690 30545397 24434212	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCF	Unknown	30545397 24434212	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCG	Unknown	30545397	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FAS	Unknown	30545397 24434212	Open Targets	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more
		FAT1	Unknown	36251745 25302557 25743686 24434212 30545397 35045690 22573403	Open Targets	—
		FAT3	Unknown	25794135 35045690 29563506 24434212	Open Targets	—
		FAT4	Unknown	25302557 25743686 24434212 30545397 35045690 29563506 22573403	Open Targets	Hippo signaling pathway - multiple species
		FBLN2	Unknown	30545397 24434212	Open Targets	Cytoskeleton in muscle cells Molecules associated with elastic fibres
		FBXO11	Unknown	30545397 35045690 29563506 24434212	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	35770320 35045690 17575125 24434212	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FCGR2B	Unknown	24434212	Open Targets	Virion - Ebolavirus, Lyssavirus and Morbillivirus Phagosome Osteoclast differentiation +6 more
		FCRL4	Unknown	24434212	Open Targets	—
		FEN1	Unknown	36251745 30545397 24434212	Open Targets	DNA replication Base excision repair Non-homologous end-joining +6 more
		FES	Unknown	30545397	Open Targets	Axon guidance Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion +1 more
		FGFR1	Unknown	23396385 24434212	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR2	Unknown	36251745 30545397 24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FGFR3	Unknown	22869148 11529856 24434212 9763594 37452600 30545397 35045690 9207791 12368157 11157491 9354676 29563506 12040455 22573403 12139740 12835230 24335104 26918361 11429702	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FGFR4	Unknown	35045690 30545397 24434212	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		FH	Unknown	30545397 35045690 24434212	Open Targets	Citrate cycle (TCA cycle) Pyruvate metabolism Metabolic pathways +5 more
		FHIT	Unknown	30545397 22573403 24434212	Open Targets	Purine metabolism Metabolic pathways Small cell lung cancer +1 more
		FIP1L1	Unknown	35045690 30545397 24434212	Open Targets	mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway +4 more
		FKBP9	Unknown	30545397 24434212	Open Targets	—
		FLCN	Unknown	35045690 30545397 24434212	Open Targets	mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1
		FLI1	Unknown	24434212	Open Targets	Transcriptional misregulation in cancer
		FLNA	Unknown	30545397 24434212	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		FLT3	Unknown	35770320 35380239 22573403 24434212	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more

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Plasma cell myeloma

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