Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
plasma cell myeloma	MONDO_0009693	CRTC3	Unknown	30545397 24434212	Open Targets	Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock
		CSF1R	Unknown	30545397 24434212	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CSF3R	Unknown	29386642 24434212	Open Targets	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		CSMD3	Unknown	36251745 24434212 30545397 35045690 29563506 22573403 23396385	Open Targets	—
		CTCF	Unknown	35045690 30545397 24434212	Open Targets	—
		CTNNA1	Unknown	36251745 35045690 24434212	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +9 more
		CTNNA2	Unknown	30545397 35045690 24434212	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		CTNNB1	Unknown	30545397 24335104 24434212	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		CTNND1	Unknown	35045690 24434212	Open Targets	Rap1 signaling pathway Adherens junction Leukocyte transendothelial migration +3 more
		CTNND2	Unknown	30545397 23396385 24434212	Open Targets	Wnt signaling pathway
		CUL3	Unknown	24434212	Open Targets	Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL +4 more
		CUX1	Unknown	35045690 30545397 29386642 24434212	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		CXCR4	Unknown	29563506 26918361 24434212	Open Targets	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Calcium signaling pathway +15 more
		CYLD	Unknown	17692805 25302557 24434212 30545397 35045690 35770320 29563506 22573403 17692804 26918361	Open Targets	NF-kappa B signaling pathway Necroptosis Osteoclast differentiation +9 more
		CYP2C8	Unknown	36251745 24434212	Open Targets	Arachidonic acid metabolism Linoleic acid metabolism Retinol metabolism +10 more
		CYSLTR2	Unknown	24434212	Open Targets	Calcium signaling pathway Neuroactive ligand-receptor interaction Glucagon signaling in metabolic regulation +6 more
		DAXX	Unknown	30545397 24434212	Open Targets	MAPK signaling pathway Apoptosis Parkinson disease +6 more
		DCAF12L2	Unknown	24434212	Open Targets	—
		DCC	Unknown	35045690 30545397 24434212	Open Targets	Axon guidance Pathways in cancer Colorectal cancer +3 more
		DCTN1	Unknown	30545397 24434212	Open Targets	Motor proteins Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis +15 more
		DDB2	Unknown	24434212	Open Targets	Nucleotide excision repair p53 signaling pathway Ubiquitin mediated proteolysis +23 more
		DDIT3	Unknown	30545397	Open Targets	MAPK signaling pathway Protein processing in endoplasmic reticulum Apoptosis +9 more
		DDR2	Unknown	30545397 24434212	Open Targets	Non-integrin membrane-ECM interactions
		DDX10	Unknown	30545397 24434212	Open Targets	—
		DDX3X	Unknown	30545397 24434212	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		DDX5	Unknown	30545397 24434212	Open Targets	Spliceosome Transcriptional misregulation in cancer Proteoglycans in cancer +3 more
		DDX6	Unknown	30545397 24434212	Open Targets	RNA degradation mRNA decay by 5' to 3' exoribonuclease
		DEK	Unknown	24434212	Open Targets	B-WICH complex positively regulates rRNA expression Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Transcriptional regulation of granulopoiesis
		DGCR8	Unknown	24434212	Open Targets	MicroRNA (miRNA) biogenesis
		DICER1	Unknown	30545397 29563506 24434212	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		DNM2	Unknown	35045690 24434212	Open Targets	Phospholipase D signaling pathway Endocytosis Fc gamma R-mediated phagocytosis +13 more
		DNMT3A	Unknown	29563506 35045690 30545397 29386642 24434212	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		DROSHA	Unknown	30545397 24434212	Open Targets	Ribosome biogenesis in eukaryotes Proteoglycans in cancer MicroRNA (miRNA) biogenesis
		EBF1	Unknown	35045690 24434212	Open Targets	—
		ECT2L	Unknown	30545397 24434212	Open Targets	—
		EED	Unknown	24434212	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +4 more
		EGFR	Unknown	36251745 27246973 25302557 24434212 18006781 30545397 23856246 35045690 28492226 24335104 23396385 26918361	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EIF1AX	Unknown	30545397 24434212	Open Targets	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits +3 more
		EIF3E	Unknown	24434212	Open Targets	Hepatitis C L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation +4 more
		EIF4A2	Unknown	36251745 24434212	Open Targets	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA +4 more
		ELF3	Unknown	35045690 30545397 24434212	Open Targets	Pre-NOTCH Transcription and Translation
		ELK4	Unknown	30545397 24434212	Open Targets	MAPK signaling pathway Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer
		ELL	Unknown	24434212	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +4 more
		ELN	Unknown	35045690 24434212	Open Targets	Cytoskeleton in muscle cells Protein digestion and absorption Degradation of the extracellular matrix +2 more
		EML4	Unknown	30545397 24434212	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		EP300	Unknown	30545397 24434212	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPAS1	Unknown	30545397 24434212	Open Targets	HIF-1 signaling pathway Pathways in cancer Renal cell carcinoma +6 more
		EPHA3	Unknown	30545397 22573403 24434212	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPHA7	Unknown	24434212	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPS15	Unknown	30545397 24434212	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more

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Plasma cell myeloma

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