Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
plasma cell myeloma	MONDO_0009693	BARD1	Unknown	30545397 24434212	Open Targets	Homologous recombination HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +11 more
		BAX	Unknown	30545397 24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +52 more
		BAZ1A	Unknown	35045690 30545397 24434212	Open Targets	ATP-dependent chromatin remodeling
		BCL10	Unknown	35045690 30545397 24434212	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		BCL11A	Unknown	24434212	Open Targets	—
		BCL11B	Unknown	35045690 24434212	Open Targets	Transcriptional misregulation in cancer
		BCL2	Unknown	24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
		BCL6	Unknown	30545397 22573403 24434212	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCL7A	Unknown	29563506 24434212	Open Targets	ATP-dependent chromatin remodeling
		BCL9	Unknown	35045690 30545397 23396385 24434212	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCL9L	Unknown	35045690 30545397	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCLAF1	Unknown	30545397 24434212	Open Targets	—
		BCOR	Unknown	30545397 24434212	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	30545397 29563506 29386642 24434212	Open Targets	Polycomb repressive complex
		BCR	Unknown	36251745 30545397 2232886 22573403 24434212	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BIRC3	Unknown	29563506 17692805 17692804 24434212	Open Targets	Platinum drug resistance NF-kappa B signaling pathway Ubiquitin mediated proteolysis +23 more
		BIRC6	Unknown	35045690 30545397 24434212	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BLM	Unknown	30545397 29563506 24434212	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		BMP5	Unknown	35045690 24434212	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway
		BMPR1A	Unknown	30545397 24434212	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +4 more
		BRAF	Unknown	24997557 24434212 14616967 32043788 26090869 21910720 28427158 28492226 20331454 29563506 22573403 23044976 36251745 25794135 24445188 37452600 23396385 35045690 35770320 35396243 25133896 14749708 24335104 26918361 25302557 25743686 30545397 35847743 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	30545397 24997557 24434212	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	30545397 29563506 24434212	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BRD3	Unknown	24434212	Open Targets	—
		BRD4	Unknown	35045690 30545397 24434212	Open Targets	—
		BRIP1	Unknown	35045690 30545397 24434212	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +8 more
		BTG1	Unknown	29563506 24434212	Open Targets	RNA degradation FOXO-mediated transcription of cell cycle genes
		BTG2	Unknown	30545397 24434212	Open Targets	RNA degradation TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
		BTK	Unknown	30545397	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Platelet activation +17 more
		BUB1B	Unknown	35045690 30545397 24434212	Open Targets	Cell cycle Human T-cell leukemia virus 1 infection Inactivation of APC/C via direct inhibition of the APC/C complex +9 more
		CACNA1D	Unknown	24434212	Open Targets	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +35 more
		CALR	Unknown	30545397	Open Targets	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CAMTA1	Unknown	30545397 23396385 24434212	Open Targets	—
		CANT1	Unknown	30545397 24434212	Open Targets	Purine metabolism Pyrimidine metabolism Metabolic pathways +2 more
		CARD11	Unknown	30545397 29563506 26918361 24434212	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CARS1	Unknown	30545397 22573403 24434212	Open Targets	Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation
		CASP3	Unknown	35045690 24434212	Open Targets	Platinum drug resistance MAPK signaling pathway p53 signaling pathway +53 more
		CASP8	Unknown	30545397 28481359 24434212	Open Targets	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CASP9	Unknown	30545397 24434212	Open Targets	Platinum drug resistance p53 signaling pathway PI3K-Akt signaling pathway +39 more
		CBFA2T3	Unknown	30545397 24434212	Open Targets	—
		CBFB	Unknown	24434212	Open Targets	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
		CBL	Unknown	36251745 29386642 24434212	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CBLB	Unknown	24434212	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CBLC	Unknown	23856246 24434212	Open Targets	Ubiquitin mediated proteolysis Endocytosis
		CCDC6	Unknown	30545397 24434212	Open Targets	Pathways in cancer Thyroid cancer
		CCNB1IP1	Unknown	30545397 24434212	Open Targets	—
		CCNC	Unknown	24434212	Open Targets	PPARA activates gene expression Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription +3 more
		CCND1	Unknown	25743686 24434212 30545397 35045690 29563506 26918361	Open Targets	Endocrine resistance FoxO signaling pathway Cell cycle +58 more
		CCND2	Unknown	23856246 24434212	Open Targets	FoxO signaling pathway Cell cycle p53 signaling pathway +18 more
		CCND3	Unknown	25794135 35045690 29563506 24434212 30545397	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more

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Plasma cell myeloma

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