Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
plasma cell myeloma	MONDO_0009693	IGF2BP2	Unknown	35045690 30545397 24434212	Open Targets	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IKBKB	Unknown	30545397 29563506 24434212	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IKZF1	Unknown	35045690 30545397 24434212	Open Targets	—
		IKZF3	Unknown	30545397 26918361 24434212	Open Targets	—
		IL2	Unknown	24434212	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway +21 more
		IL21R	Unknown	30545397 24434212	Open Targets	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL6ST	Unknown	24434212 30545397 35045690 29563506 23396385 26918361	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		IL7R	Unknown	35045690 24434212	Open Targets	Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway +7 more
		IRF4	Unknown	24434212 30545397 35045690 29563506 22573403 23396385 26918361	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		IRS4	Unknown	30545397 24434212	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		ISX	Unknown	24434212	Open Targets	—
		ITGAV	Unknown	30545397 24434212	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		ITK	Unknown	35045690 24434212	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	36251745 35045690 24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	29563506 26918361 24434212 35380239	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	30545397 24335104 24434212	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		JAZF1	Unknown	24434212	Open Targets	—
		KAT6A	Unknown	35045690 30545397 24434212	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT6B	Unknown	35045690 30545397 24434212	Open Targets	HATs acetylate histones
		KAT7	Unknown	30545397 24434212	Open Targets	HATs acetylate histones
		KCNJ5	Unknown	24434212	Open Targets	Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse +8 more
		KDM5A	Unknown	30545397 24434212	Open Targets	HDMs demethylate histones
		KDM5C	Unknown	35045690 24434212	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	36251745 24434212 30545397 19330029 29563506 22573403 29386642 26918361	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	35045690 24434212	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KDSR	Unknown	24434212	Open Targets	Sphingolipid metabolism Metabolic pathways Sphingolipid de novo biosynthesis
		KEAP1	Unknown	24434212	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIAA1549	Unknown	35045690 30545397 24434212	Open Targets	Signaling by BRAF and RAF fusions
		KIF5B	Unknown	35045690 30545397 24434212	Open Targets	Endocytosis Dopaminergic synapse Motor proteins +12 more
		KIT	Unknown	30545397 35045690 29563506 24335104 24434212	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KLF4	Unknown	30545397 24434212	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KLF6	Unknown	24434212	Open Targets	—
		KMT2A	Unknown	24434212 30545397 35045690 35770320 29563506 22573403 23396385	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	35045690 30545397 25302557 24434212	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	35045690 30545397 23396385 22573403 24434212	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	35045690 30545397 24434212	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KNSTRN	Unknown	30545397	Open Targets	—
		KRAS	Unknown	14616967 24434212 12068308 28234344 26090869 11157491 28492226 20331454 29563506 22573403 29386642 17036375 36251745 24726492 25794135 23856246 2681517 37452600 8490179 23396385 21149634 35045690 35396243 24335104 26918361 25302557 25743686 30545397 22939401	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	30545397 24434212	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	30545397 24434212	Open Targets	—
		LASP1	Unknown	24434212	Open Targets	—
		LATS1	Unknown	30545397 24434212	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	30545397 24434212	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCK	Unknown	24434212	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Natural killer cell mediated cytotoxicity +27 more
		LCP1	Unknown	35045690 30545397 24434212	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LEF1	Unknown	30545397 24434212	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		LEPROTL1	Unknown	24434212	Open Targets	—
		LHFPL6	Unknown	24434212	Open Targets	—
		LIFR	Unknown	30545397 24434212	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more
		LMNA	Unknown	30545397 35045690 24434212	Open Targets	Apoptosis Cytoskeleton in muscle cells Hypertrophic cardiomyopathy +8 more

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Plasma cell myeloma

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