Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
peripheral T-cell lymphoma, not otherwise specified	MONDO_0004964	NUP98	Unknown	27203213	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		PIK3CA	Unknown	27203213	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	27203213	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R2	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more
		PIK3R3	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +116 more
		PLCG1	Unknown	29662631 25304611	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PMS2	Unknown	27203213	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLE	Unknown	27203213	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PRKCB	Unknown	30097855	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PTCH1	Unknown	27203213	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	29662631 9931326	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	27203213	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPRD	Unknown	27203213	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRT	Unknown	27203213 28481359	Open Targets	—
		RAD50	Unknown	27203213	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51B	Unknown	27203213	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAD51C	Unknown	27203213	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RASA1	Unknown	27203213	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RHOA	Unknown	31394087 24413734 24413737 27369867 29662631 24786457 24584070 28481359 26268241	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RNF213	Unknown	25257991	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		SETBP1	Unknown	27203213 25257991	Open Targets	—
		SETD2	Unknown	27203213 29305415	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SF3B1	Unknown	27203213	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SH2B3	Unknown	27203213	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SMAD3	Unknown	27203213	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMARCA4	Unknown	27203213	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	24413734	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SMC1A	Unknown	27203213	Open Targets	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
		SOX2	Unknown	27203213	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SPEN	Unknown	27203213 24413734	Open Targets	Notch signaling pathway
		SRC	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more
		STAG2	Unknown	27203213	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAT3	Unknown	23563237 27203213 23317146 23872306 29662631	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STAT5B	Unknown	27203213 25257991	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more
		STIL	Unknown	8321044	Open Targets	—
		STK11	Unknown	27203213	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		TAL1	Unknown	8321044	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		TBL1XR1	Unknown	22855598	Open Targets	Wnt signaling pathway RORA activates gene expression PPARA activates gene expression +11 more
		TBX3	Unknown	27203213	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TCF3	Unknown	27203213	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TERT	Unknown	27203213	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TET1	Unknown	25257991	Open Targets	—
		TET2	Unknown	21723201 24413734 31394087 24413737 29662631 22216861 29305415 27203213 29386642 25257991 28481359 26268241	Open Targets	—
		TNFAIP3	Unknown	25257991	Open Targets	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
		TNFRSF14	Unknown	25257991	Open Targets	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TP53	Unknown	17609875 29662631 8219205 27203213 11896204 29386642 25257991 28481359	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	27203213 22855598	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TRAF7	Unknown	27203213	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TSC1	Unknown	27203213	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	27203213	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more

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Peripheral t-cell lymphoma, not otherwise specified

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