Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
peripheral T-cell lymphoma, not otherwise specified	MONDO_0004964	ERBB2	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERCC2	Unknown	28481359	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERG	Unknown	27203213	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		EXT2	Unknown	27203213	Open Targets	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis +2 more
		FANCA	Unknown	27203213	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FAS	Unknown	29662631 8598453	Open Targets	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more
		FAT1	Unknown	27203213	Open Targets	—
		FBXO11	Unknown	27203213	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	27203213 25257991	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR1	Unknown	27203213	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FIP1L1	Unknown	27203213	Open Targets	mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway +4 more
		FLT4	Unknown	27203213	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FOXO1	Unknown	25257991	Open Targets	FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway +23 more
		GATA3	Unknown	28481359	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action +6 more
		GRIN2A	Unknown	27203213	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		HGF	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HRAS	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IDH2	Unknown	29662631 25257991 31394087 28481359	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IL6ST	Unknown	27203213	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		IL7R	Unknown	25257991	Open Targets	Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway +7 more
		IRF4	Unknown	25257991	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		IRS4	Unknown	24413734	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		JAK1	Unknown	29662631	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK3	Unknown	25257991	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KAT6A	Unknown	27203213	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KDM6A	Unknown	25257991 29305415	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KIT	Unknown	11927008 16321856	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	25257991 29305415	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	27203213 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	27203213 25257991 29305415	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	27203213 11896204	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LATS1	Unknown	27203213	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		MAP2K2	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MAP3K1	Unknown	28481359	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAPK1	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MED12	Unknown	27203213	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MITF	Unknown	28481359	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MPL	Unknown	27203213	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MSH6	Unknown	27203213	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		NCOR1	Unknown	27203213	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NF1	Unknown	25257991 24413734	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NKX2-1	Unknown	27203213	Open Targets	—
		NOTCH1	Unknown	27203213 28481359 17483057	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	27203213	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NPM1	Unknown	8701987 7662979 8558920 8781434 8781433 11178628 7579458	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NR4A3	Unknown	24413734	Open Targets	Transcriptional misregulation in cancer Nuclear Receptor transcription pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
		NRAS	Unknown	20861915 2004329	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NTRK1	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more

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Peripheral t-cell lymphoma, not otherwise specified

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