Subtype of: Melanoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
nodular malignant melanoma	MONDO_0000930	KLK2	Unknown	26359337	Open Targets	Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption Activation of Matrix Metalloproteinases +2 more
		KMT2A	Unknown	33024263 26359337	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	22197931 33024263 36219477 30178487 26359337	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	33024263 36219477 26359337	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	33024263	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KNSTRN	Unknown	36219477	Open Targets	—
		KRAS	Unknown	2691957 33024263 36219477 26359337 15195137 21176117 28356599	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	33024263	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	33024263	Open Targets	—
		LATS1	Unknown	33024263 26359337 30178487	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	33024263 26359337 30178487	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCK	Unknown	26359337	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Natural killer cell mediated cytotoxicity +27 more
		LCP1	Unknown	30178487	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LIFR	Unknown	33024263 26359337 30178487	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more
		LOC100506403	Unknown	33024263 36219477	Open Targets	—
		LOC105376156	Unknown	33024263 36219477	Open Targets	—
		LOC124905021	Unknown	33024263	Open Targets	—
		LPP	Unknown	26359337	Open Targets	—
		LRIG3	Unknown	33024263 26359337	Open Targets	—
		LRP1B	Unknown	22197931 33024263 26359337 30178487 36219477	Open Targets	—
		LSM14A	Unknown	26359337	Open Targets	—
		LYN	Unknown	36219477	Open Targets	Chemokine signaling pathway NF-kappa B signaling pathway Platelet activation +36 more
		LZTR1	Unknown	26359337 30178487 36219477	Open Targets	—
		MACC1	Unknown	33024263 26359337 30178487	Open Targets	—
		MAF	Unknown	26359337	Open Targets	Th1 and Th2 cell differentiation Transcriptional misregulation in cancer Inflammatory bowel disease
		MAFB	Unknown	26359337	Open Targets	Parathyroid hormone synthesis, secretion and action
		MALT1	Unknown	33024263 30178487	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		MAML2	Unknown	33024263	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP2K1	Unknown	22197931 33024263 36219477 36901951 26359337	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP2K2	Unknown	22197931 33024263 36219477	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MAP2K4	Unknown	33024263 36219477	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	36219477 26359337	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	33024263 36219477 26359337	Open Targets	MAPK signaling pathway
		MAPK1	Unknown	26359337 36219477	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MAX	Unknown	36219477	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MDM2	Unknown	36219477 30178487	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		MDM4	Unknown	33024263 36219477	Open Targets	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MECOM	Unknown	33024263 36219477 30178487 26359337	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MED12	Unknown	33024263 36219477	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEN1	Unknown	26359337 30178487 36219477	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	33024263 36219477 30178487	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MGMT	Unknown	22197931 30178487	Open Targets	MGMT-mediated DNA damage reversal
		MITF	Unknown	22197931 33024263 36219477 26359337	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLF1	Unknown	26359337	Open Targets	Transcriptional misregulation in cancer
		MLH1	Unknown	36219477 30178487 12696065	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT1	Unknown	33024263 26359337	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MLLT10	Unknown	33024263	Open Targets	—
		MLLT11	Unknown	36219477 26359337	Open Targets	—
		MLLT3	Unknown	33024263 26359337	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MN1	Unknown	36219477 30178487	Open Targets	—

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Nodular malignant melanoma

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