Subtype of: Melanoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
nodular malignant melanoma	MONDO_0000930	MPL	Unknown	33024263 36219477 30178487	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MRTFA	Unknown	33024263 36219477 30178487	Open Targets	SUMOylation of transcription cofactors RHO GTPases Activate Formins
		MSH2	Unknown	36219477 26359337	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	33024263 26359337	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MSI2	Unknown	36219477	Open Targets	mRNA surveillance pathway
		MTCP1	Unknown	33024263	Open Targets	PI3K-Akt signaling pathway
		MTOR	Unknown	33024263 26359337 30178487 36219477	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC1	Unknown	33024263 26359337	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +4 more
		MUC16	Unknown	33024263 26359337 30178487	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	33024263 26359337 30178487	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC6	Unknown	33024263 26359337 30178487	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUTYH	Unknown	26359337	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYB	Unknown	22197931 33024263 26359337 36219477	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		MYC	Unknown	33024263 36219477 26359337	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYCL	Unknown	33024263 36219477	Open Targets	—
		MYCN	Unknown	33024263 36219477	Open Targets	Transcriptional misregulation in cancer
		MYD88	Unknown	26359337	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		MYH11	Unknown	33024263 26359337 30178487	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		MYH9	Unknown	33024263 26359337 30178487	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		MYO5A	Unknown	33024263	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		MYOD1	Unknown	33024263	Open Targets	Spinocerebellar ataxia Myogenesis
		N4BP2	Unknown	22197931 33024263 26359337	Open Targets	—
		NACA	Unknown	33024263 26359337	Open Targets	Parathyroid hormone synthesis, secretion and action
		NBEA	Unknown	33024263 26359337 30178487	Open Targets	—
		NCOA1	Unknown	33024263 26359337	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer +18 more
		NCOA2	Unknown	33024263	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NCOR1	Unknown	33024263 36219477 30178487	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NCOR2	Unknown	33024263 26359337	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NDRG1	Unknown	26359337	Open Targets	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
		NF1	Unknown	33024263 26076063 36219477 30178487 22197931 26359337 28356599	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NF2	Unknown	33024263 36219477	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NFATC2	Unknown	22197931 33024263 26359337	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis +24 more
		NFE2L2	Unknown	33024263 36219477	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFIB	Unknown	33024263 36219477	Open Targets	—
		NFKB2	Unknown	26359337	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more
		NFKBIE	Unknown	36219477	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway +6 more
		NIN	Unknown	33024263 26359337	Open Targets	—
		NKX2-1	Unknown	36219477	Open Targets	—
		NONO	Unknown	33024263 26359337 30178487	Open Targets	—
		NOTCH1	Unknown	33024263 36219477 30178487 26359337	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	22197931 33024263 26359337 36219477	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NR2F2	Unknown	33024263	Open Targets	—
		NRAS	Unknown	7576742 16098042 33024263 36219477 17535228 7860615 20544847 20520630 8780392 9804334 21356389 22197931 8043423 22493355 20720566 9793966 25767048 30178487 15195137 28870692 21176117 20460471 22020039 22536370 11886512 26359337 12783933	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NRG1	Unknown	33024263 26359337	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD1	Unknown	22197931 33024263 26359337 30178487	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NSD2	Unknown	22197931	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		NSD3	Unknown	33024263 26359337 30178487	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTHL1	Unknown	33024263	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine +3 more
		NTRK1	Unknown	22197931 33024263 26359337 30178487 36219477	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	22197931 36219477	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more

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Nodular malignant melanoma

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