Myocardial infarction

Calcium signaling pathway

Telomere C-strand synthesis initiation

Nucleocytoplasmic transport Fluid shear stress and atherosclerosis SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation +22 more

Arachidonic acid metabolism Metabolic pathways Platelet activation Eicosanoids Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) +3 more

Complement and coagulation cascades Extrinsic Pathway of Fibrin Clot Formation

MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway Cell cycle Efferocytosis Cellular senescence TGF-beta signaling pathway Osteoclast differentiation Hippo signaling pathway Th17 cell differentiation Intestinal immune network for IgA production Relaxin signaling pathway Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Leishmaniasis Chagas disease Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Proteoglycans in cancer Colorectal cancer Renal cell carcinoma Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Inflammatory bowel disease Rheumatoid arthritis Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Platelet degranulation Influenza Virus Induced Apoptosis Cell surface interactions at the vascular wall Molecules associated with elastic fibres Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Syndecan interactions SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Interleukin-4 and Interleukin-13 signaling RUNX3 regulates CDKN1A transcription Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF +49 more

tRNA modification in the nucleus and cytosol

Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications Fluid shear stress and atherosclerosis Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall +2 more

Activation of Matrix Metalloproteinases Neutrophil degranulation

NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome PI3K-Akt signaling pathway Necroptosis Neutrophil extracellular trap formation Toll-like receptor signaling pathway NOD-like receptor signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis B Measles Influenza A Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Proteoglycans in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Rheumatoid arthritis Lipid and atherosclerosis ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation +41 more

Cytoskeleton in muscle cells Striated Muscle Contraction

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway Sphingolipid signaling pathway mTOR signaling pathway Apoptosis Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage Natural killer cell mediated cytotoxicity IL-17 signaling pathway T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Proteoglycans in cancer Asthma Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Hypertrophic cardiomyopathy Dilated cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling +72 more

PI Metabolism

Cytokine-cytokine receptor interaction TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Cytokine-cytokine receptor interaction TNFs bind their physiological receptors

Cytokine-cytokine receptor interaction TNFs bind their physiological receptors

cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Striated Muscle Contraction Ion homeostasis +7 more

Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +12 more

SUMOylation of DNA replication proteins

Endocrine resistance Platinum drug resistance MAPK signaling pathway Sphingolipid signaling pathway Cell cycle p53 signaling pathway Mitophagy - animal PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Ferroptosis Cellular senescence Wnt signaling pathway Neurotrophin signaling pathway Thyroid hormone signaling pathway Parkinson disease Amyotrophic lateral sclerosis Huntington disease Shigellosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Basal cell carcinoma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription +85 more

Tyrosine metabolism Metabolic pathways Thyroid hormone synthesis Autoimmune thyroid disease Thyroxine biosynthesis +2 more

NGF-stimulated transcription

Viral life cycle - HIV-1 Human immunodeficiency virus 1 infection Interferon gamma signaling

Neutrophil degranulation Amyloid fiber formation

Carboxyterminal post-translational modifications of tubulin

Proteoglycans in cancer Interleukin-4 and Interleukin-13 signaling Regulation of RUNX2 expression and activity

Ubiquitin mediated proteolysis Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation

Cytokine-cytokine receptor interaction TNFs bind their physiological receptors