Multiple sclerosis

Complement and coagulation cascades Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly +3 more

Fatty acid biosynthesis Valine, leucine and isoleucine degradation Metabolic pathways Fatty acid metabolism Synthesis of very long-chain fatty acyl-CoAs +2 more

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Purine metabolism Metabolic pathways Endocrine resistance Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Longevity regulating pathway Longevity regulating pathway - multiple species Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Gap junction Platelet activation Circadian entrainment Thermogenesis Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse GABAergic synapse Olfactory transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Ovarian steroidogenesis Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Vasopressin-regulated water reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Bile secretion Morphine addiction Vibrio cholerae infection Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis +61 more

Transcriptional misregulation in cancer

FoxO signaling pathway Endocytosis

Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications Alzheimer disease Pathways of neurodegeneration - multiple diseases Diabetic cardiomyopathy Lipid and atherosclerosis TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation +7 more

Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways Phospholipase D signaling pathway Fat digestion and absorption Synthesis of PA ChREBP activates metabolic gene expression +4 more

Anchoring of the basal body to the plasma membrane

NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway The AIM2 inflammasome

Parathyroid hormone synthesis, secretion and action Human cytomegalovirus infection NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events +2 more

One carbon pool by folate Metabolic pathways Metabolism of folate and pterines

Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism Lipid and atherosclerosis +1 more

Cholesterol metabolism Chylomicron assembly Chylomicron remodeling HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +3 more

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

Rho GTPase cycle

Rho GTPase cycle

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Endocytosis Fc gamma R-mediated phagocytosis VxPx cargo-targeting to cilium

Endocytosis Fc gamma R-mediated phagocytosis

Aldosterone synthesis and secretion Transcriptional misregulation in cancer CREB phosphorylation NGF-stimulated transcription +1 more

cGMP-PKG signaling pathway Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Longevity regulating pathway Adrenergic signaling in cardiomyocytes TNF signaling pathway Dopaminergic synapse Insulin secretion Estrogen signaling pathway Thyroid hormone synthesis Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Prion disease Cocaine addiction Amphetamine addiction Alcoholism Hepatitis B Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Chemical carcinogenesis - receptor activation +22 more

Oxidative phosphorylation Metabolic pathways Thermogenesis Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Formation of ATP by chemiosmotic coupling Cristae formation +10 more

Oxidative phosphorylation Metabolic pathways Thermogenesis Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Formation of ATP by chemiosmotic coupling Cristae formation +10 more

Notch signaling pathway Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Platinum drug resistance Protein processing in endoplasmic reticulum Apoptosis Apoptosis - multiple species Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Hepatitis C Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Thyroid cancer Basal cell carcinoma Melanoma Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria +32 more

PD-L1 expression and PD-1 checkpoint pathway in cancer Interleukin-4 and Interleukin-13 signaling

PD-L1 expression and PD-1 checkpoint pathway in cancer

Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance NF-kappa B signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway p53 signaling pathway Autophagy - animal Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Adrenergic signaling in cardiomyocytes Hedgehog signaling pathway Focal adhesion NOD-like receptor signaling pathway JAK-STAT signaling pathway Neurotrophin signaling pathway Cholinergic synapse Estrogen signaling pathway Parathyroid hormone synthesis, secretion and action AGE-RAGE signaling pathway in diabetic complications Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Shigellosis Salmonella infection Toxoplasmosis Tuberculosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Prostate cancer Small cell lung cancer Gastric cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling +46 more

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Viral life cycle - HIV-1 COPI-independent Golgi-to-ER retrograde traffic

cGMP-PKG signaling pathway Apelin signaling pathway Myogenesis

Butyrophilin (BTN) family interactions

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more