Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
LUNG ADENOCARCINOMA	EFO_0000571	BTN3A1	Unknown	28604730	GWAS catalog	Butyrophilin (BTN) family interactions
		BTNL2	Unknown	22797724 27501781	GWAS catalog	Butyrophilin (BTN) family interactions
		BZW1	Unknown	32887889	GWAS catalog	—
		C11ORF65	Unknown	34290314 35915169	GWAS catalog	—
		C1D	Unknown	29924316	GWAS catalog	RNA degradation Major pathway of rRNA processing in the nucleolus and cytosol
		C1ORF94	Unknown	40341939	GWAS catalog	—
		C6ORF15	Unknown	28604730	GWAS catalog	—
		C6ORF52	Unknown	40341939	GWAS catalog	—
		CABLES1	Unknown	28604730	GWAS catalog	Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry
		CALCRL	Unknown	36929942	GWAS catalog	Neuroactive ligand-receptor interaction Vascular smooth muscle contraction G alpha (s) signalling events +2 more
		CAPZB	Unknown	32699080	GWAS catalog	Endocytosis Motor proteins Cytoskeleton in muscle cells +5 more
		CARMIL1	Unknown	28604730	GWAS catalog	Factors involved in megakaryocyte development and platelet production
		CASP8	Unknown	32887889 33893285 34290314	GWAS catalog	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CAST	Unknown	40341939	GWAS catalog	Shigellosis Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
		CATSPER2	Unknown	28604730	GWAS catalog	Sperm Motility And Taxes
		CBFA2T2	Unknown	32887889	GWAS catalog	—
		CCDC170	Unknown	32887889 37340002	GWAS catalog	—
		CCDC179	Unknown	40341939	GWAS catalog	—
		CCDC40	Unknown	32887889	GWAS catalog	—
		CCDC85C	Unknown	28604730	GWAS catalog	—
		CCDC91	Unknown	32887889	GWAS catalog	—
		CCHCR1	Unknown	32887889	GWAS catalog	—
		CCND1	Unknown	32887889	GWAS catalog	Endocrine resistance FoxO signaling pathway Cell cycle +58 more
		CCNE1	Unknown	32887889	GWAS catalog	Cell cycle Oocyte meiosis p53 signaling pathway +24 more
		CCR6	Unknown	28604730	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +3 more
		CCSER1	Unknown	40341939	GWAS catalog	—
		CD164	Unknown	28604730	GWAS catalog	Lysosome
		CD48	Unknown	40341939	GWAS catalog	Natural killer cell mediated cytotoxicity Cell surface interactions at the vascular wall
		CDCA7	Unknown	28604730 32887889	GWAS catalog	—
		CDH15	Unknown	32887889	GWAS catalog	Cell adhesion molecules Adherens junctions interactions Myogenesis
		CDH18	Unknown	32887889	GWAS catalog	Adherens junctions interactions
		CDK5RAP1	Unknown	34290314	GWAS catalog	—
		CDKN2A	Unknown	32887889	GWAS catalog	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CDYL2	Unknown	32887889	GWAS catalog	—
		CEACAM21	Unknown	28604730	GWAS catalog	—
		CELF2	Unknown	34290314	GWAS catalog	—
		CEP43	Unknown	28604730	GWAS catalog	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		CERS2	Unknown	32887889 34290314	GWAS catalog	Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway +1 more
		CHD2	Unknown	40341939	GWAS catalog	—
		CHD3	Unknown	32887889	GWAS catalog	ATP-dependent chromatin remodeling HDACs deacetylate histones SUMOylation of chromatin organization proteins +3 more
		CHEK2	Unknown	24880342 39366959	GWAS catalog	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CHMP4B	Unknown	34290314	GWAS catalog	Viral life cycle - HIV-1 Virion - Hepatitis viruses Endocytosis +6 more
		CHRNA2	Unknown	28604730 39366959	GWAS catalog	Neuroactive ligand-receptor interaction Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
		CHRNA3	Unknown	18978787 18978790 19836008 30104567 34290314 37340002 38970920	GWAS catalog	Neuroactive ligand-receptor interaction Cholinergic synapse Chemical carcinogenesis - receptor activation +3 more
		CHRNA4	Unknown	39366959	GWAS catalog	Neuroactive ligand-receptor interaction Cholinergic synapse Nicotine addiction +4 more
		CHRNA5	Unknown	27393504 28604730 31577861 32889700 34594039 35915169 37167549 39366959 40341939 40829600	GWAS catalog	Neuroactive ligand-receptor interaction Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
		CHRNB4	Unknown	28604730 37340002	GWAS catalog	Neuroactive ligand-receptor interaction Cholinergic synapse Chemical carcinogenesis - receptor activation +4 more
		CHURC1	Unknown	34290314	GWAS catalog	—
		CHURC1-FNTB	Unknown	34290314	GWAS catalog	Terpenoid backbone biosynthesis Inactivation, recovery and regulation of the phototransduction cascade
		CLINT1	Unknown	40341939	GWAS catalog	Golgi Associated Vesicle Biogenesis
LUNG CANCER	MONDO_0008903 MONDO:0008903	BTN3A1	Unknown	28604730	GWAS catalog	Butyrophilin (BTN) family interactions
		C11ORF65	Unknown	34290314	GWAS catalog	—
		C1ORF94	Unknown	40341939	GWAS catalog	—
		C6ORF15	Unknown	28604730	GWAS catalog	—
		CARMIL1	Unknown	28604730	GWAS catalog	Factors involved in megakaryocyte development and platelet production
		CAST	Unknown	40341939	GWAS catalog	Shigellosis Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
		CATSPER2	Unknown	28604730	GWAS catalog	Sperm Motility And Taxes
		CCDC170	Unknown	37340002	GWAS catalog	—
		CCDC40	Unknown	32887889	GWAS catalog	—
		CCR6	Unknown	28604730	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +3 more
		CD164	Unknown	28604730	GWAS catalog	Lysosome
		CD48	Unknown	40341939	GWAS catalog	Natural killer cell mediated cytotoxicity Cell surface interactions at the vascular wall
		CDCA7	Unknown	28604730 36819030	GWAS catalog	—
		CDH18	Unknown	32887889	GWAS catalog	Adherens junctions interactions
		CDK5RAP1	Unknown	34290314	GWAS catalog	—
		CELF2	Unknown	34290314	GWAS catalog	—
		CEP43	Unknown	28604730 39366959	GWAS catalog	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		CERS2	Unknown	34290314	GWAS catalog	Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway +1 more
		CHEK2	Unknown	24880342 39366959	GWAS catalog	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CHMP4B	Unknown	34290314	GWAS catalog	Viral life cycle - HIV-1 Virion - Hepatitis viruses Endocytosis +6 more
		CHRNA2	Unknown	28604730 39366959	GWAS catalog	Neuroactive ligand-receptor interaction Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
		CHRNA3	Unknown	18978787 18978790 30104567 34290314 37340002 38970920	GWAS catalog	Neuroactive ligand-receptor interaction Cholinergic synapse Chemical carcinogenesis - receptor activation +3 more
		CHRNA4	Unknown	39024449 39366959	GWAS catalog	Neuroactive ligand-receptor interaction Cholinergic synapse Nicotine addiction +4 more
		CHRNA5	Unknown	27393504 28604730 31577861 34594039 35915169 37167549 39024449 39366959 40341939 40829600	GWAS catalog	Neuroactive ligand-receptor interaction Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
		CHRNB4	Unknown	28604730 37340002	GWAS catalog, GenCC	Neuroactive ligand-receptor interaction Cholinergic synapse Chemical carcinogenesis - receptor activation +4 more
		CHURC1	Unknown	34290314	GWAS catalog	—
		CHURC1-FNTB	Unknown	34290314	GWAS catalog	Terpenoid backbone biosynthesis Inactivation, recovery and regulation of the phototransduction cascade
		CLINT1	Unknown	40341939	GWAS catalog	Golgi Associated Vesicle Biogenesis
LUNG CARCINOMA	EFO_0001071	BTN3A1	Unknown	28604730	GWAS catalog	Butyrophilin (BTN) family interactions
		BZW1	Unknown	32887889	GWAS catalog	—
		C11ORF65	Unknown	34290314	GWAS catalog	—
		C1ORF94	Unknown	40341939	GWAS catalog	—
		C6ORF15	Unknown	28604730	GWAS catalog	—
		CALCRL	Unknown	36929942	GWAS catalog	Neuroactive ligand-receptor interaction Vascular smooth muscle contraction G alpha (s) signalling events +2 more
		CARMIL1	Unknown	28604730	GWAS catalog	Factors involved in megakaryocyte development and platelet production
		CASP8	Unknown	32887889 33893285 34290314	GWAS catalog	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CAST	Unknown	40341939	GWAS catalog	Shigellosis Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
		CATSPER2	Unknown	28604730	GWAS catalog	Sperm Motility And Taxes
		CBFA2T2	Unknown	32887889	GWAS catalog	—
		CCDC170	Unknown	32887889 37340002	GWAS catalog	—
		CCDC40	Unknown	32887889	GWAS catalog	—
		CCDC91	Unknown	32887889	GWAS catalog	—
		CCHCR1	Unknown	32887889	GWAS catalog	—
		CCND1	Unknown	32887889	GWAS catalog	Endocrine resistance FoxO signaling pathway Cell cycle +58 more
		CCNE1	Unknown	32887889	GWAS catalog	Cell cycle Oocyte meiosis p53 signaling pathway +24 more
		CCR6	Unknown	28604730	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +3 more
		CD164	Unknown	28604730	GWAS catalog	Lysosome
		CD48	Unknown	40341939	GWAS catalog	Natural killer cell mediated cytotoxicity Cell surface interactions at the vascular wall
		CDCA7	Unknown	28604730 32887889	GWAS catalog	—
		CDH15	Unknown	32887889	GWAS catalog	Cell adhesion molecules Adherens junctions interactions Myogenesis
		CDH18	Unknown	32887889	GWAS catalog	Adherens junctions interactions
		CDK5RAP1	Unknown	34290314	GWAS catalog	—
		CDKN2A	Unknown	32887889	GWAS catalog	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CDYL2	Unknown	32887889	GWAS catalog	—
		CELF2	Unknown	34290314	GWAS catalog	—
		CEP43	Unknown	28604730	GWAS catalog	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		CERS2	Unknown	32887889 34290314	GWAS catalog	Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway +1 more
		CHD3	Unknown	32887889	GWAS catalog	ATP-dependent chromatin remodeling HDACs deacetylate histones SUMOylation of chromatin organization proteins +3 more
		CHEK2	Unknown	24880342 39366959	GWAS catalog	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CHMP4B	Unknown	34290314	GWAS catalog	Viral life cycle - HIV-1 Virion - Hepatitis viruses Endocytosis +6 more
		CHRNA2	Unknown	28604730 39366959	GWAS catalog	Neuroactive ligand-receptor interaction Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
		CHRNA3	Unknown	18978787 18978790 29924316 30104567 34290314 37340002 38970920 40829600	GWAS catalog	Neuroactive ligand-receptor interaction Cholinergic synapse Chemical carcinogenesis - receptor activation +3 more
		CHRNA4	Unknown	39366959	GWAS catalog	Neuroactive ligand-receptor interaction Cholinergic synapse Nicotine addiction +4 more
		CHRNA5	Unknown	27393504 28604730 31577861 34594039 35915169 37167549 39366959 40341939 40829600	GWAS catalog	Neuroactive ligand-receptor interaction Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
		CHRNB4	Unknown	28604730 37340002 40829600	GWAS catalog	Neuroactive ligand-receptor interaction Cholinergic synapse Chemical carcinogenesis - receptor activation +4 more
		CHURC1	Unknown	34290314	GWAS catalog	—
		CHURC1-FNTB	Unknown	34290314	GWAS catalog	Terpenoid backbone biosynthesis Inactivation, recovery and regulation of the phototransduction cascade
		CLINT1	Unknown	40341939	GWAS catalog	Golgi Associated Vesicle Biogenesis

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Lung cancer

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