Liver cirrhosis

EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Intestinal immune network for IgA production Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Hepatitis B Measles Human cytomegalovirus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Hypertrophic cardiomyopathy Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response +59 more

MAPK signaling pathway Osteoclast differentiation IL-17 signaling pathway Parathyroid hormone synthesis, secretion and action Estrogen-dependent gene expression NGF-stimulated transcription +3 more

Antigen processing and presentation Graft-versus-host disease DAP12 interactions

Chemical carcinogenesis - receptor activation

Estrogen signaling pathway Staphylococcus aureus infection Keratinization Formation of the cornified envelope +1 more

Keratinization Formation of the cornified envelope

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Toxoplasmosis Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Type I hemidesmosome assembly MET activates PTK2 signaling +11 more

Virion - Hepatitis viruses Endocytosis Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Bile secretion Cholesterol metabolism Toxoplasmosis Hepatitis C Lipid and atherosclerosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance +12 more

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

Platelet degranulation

Elastic fibre formation Crosslinking of collagen fibrils

Elastic fibre formation Crosslinking of collagen fibrils

Proteoglycans in cancer Keratan sulfate biosynthesis Keratan sulfate degradation Integrin cell surface interactions Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) +4 more

Phagosome Complement and coagulation cascades Staphylococcus aureus infection Coronavirus disease - COVID-19 Lectin pathway of complement activation Initial triggering of complement +3 more

Processing of Capped Intron-Containing Pre-mRNA

Glycerolipid metabolism Metabolic pathways Thermogenesis Retrograde endocannabinoid signaling Regulation of lipolysis in adipocytes Acyl chain remodeling of DAG and TAG Arachidonate production from DAG +4 more

Endocrine resistance Leukocyte transendothelial migration GnRH signaling pathway Estrogen signaling pathway Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Proteoglycans in cancer Bladder cancer Diabetic cardiomyopathy Fluid shear stress and atherosclerosis Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling +15 more

Drug metabolism - other enzymes Phagosome Neutrophil extracellular trap formation Transcriptional misregulation in cancer Acute myeloid leukemia Neutrophil degranulation Events associated with phagocytolytic activity of PMN cells +4 more

SUMOylation of transcription cofactors RHO GTPases Activate Formins

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Lipid and atherosclerosis Fluid shear stress and atherosclerosis +4 more

Virion - Ebolavirus, Lyssavirus and Morbillivirus Lysosome Cholesterol metabolism LDL clearance +1 more

cGMP-PKG signaling pathway cAMP signaling pathway HIF-1 signaling pathway Hormone signaling Vascular smooth muscle contraction Thermogenesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Renin secretion Aldosterone synthesis and secretion African trypanosomiasis YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation +11 more

Calcium signaling pathway Neuroactive ligand-receptor interaction NOD-like receptor signaling pathway Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection +4 more

Collagen biosynthesis and modifying enzymes Crosslinking of collagen fibrils

Glycerophospholipid metabolism Metabolic pathways Synthesis of PC

Calcium signaling pathway Insulin signaling pathway Glucagon signaling pathway Glycogen breakdown (glycogenolysis) +1 more

NF-kappa B signaling pathway Complement and coagulation cascades Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Prostate cancer Neutrophil degranulation Dissolution of Fibrin Clot +5 more

Lysine degradation Metabolic pathways Collagen biosynthesis and modifying enzymes

Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance FoxO signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway p53 signaling pathway Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway Cellular senescence Focal adhesion Insulin resistance Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Endometrial cancer Glioma Prostate cancer Melanoma Small cell lung cancer Breast cancer Hepatocellular carcinoma Central carbon metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Diabetic cardiomyopathy Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Negative regulation of the PI3K/AKT network Downstream TCR signaling TP53 Regulates Metabolic Genes PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2 +37 more

Arachidonic acid metabolism Metabolic pathways NF-kappa B signaling pathway Efferocytosis VEGF signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Retrograde endocannabinoid signaling Serotonergic synapse Ovarian steroidogenesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Alzheimer disease Pathways of neurodegeneration - multiple diseases Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Chemical carcinogenesis - DNA adducts MicroRNAs in cancer Small cell lung cancer Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives +29 more

Renin-angiotensin system Renin secretion Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +1 more

Pentose phosphate pathway Ascorbate and aldarate metabolism Metabolic pathways Carbon metabolism Biosynthesis of cofactors +2 more

Glucocorticoid biosynthesis

HIF-1 signaling pathway p53 signaling pathway Cellular senescence Apelin signaling pathway Hippo signaling pathway Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications Chagas disease Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot +10 more

Complement and coagulation cascades Pertussis Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Regulation of Complement cascade +2 more

Collagen biosynthesis and modifying enzymes

EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway Ras signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway Focal adhesion Natural killer cell mediated cytotoxicity Neurotrophin signaling pathway Insulin signaling pathway Estrogen signaling pathway Prolactin signaling pathway Relaxin signaling pathway Growth hormone synthesis, secretion and action Alcoholism Bacterial invasion of epithelial cells MicroRNAs in cancer Glioma Chronic myeloid leukemia Breast cancer Hepatocellular carcinoma Gastric cancer Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling DAP12 signaling SHC-related events triggered by IGF1R Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 SHC-mediated cascade:FGFR2 SHC-mediated cascade:FGFR3 SHC-mediated cascade:FGFR4 RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade MET activates RAS signaling RET signaling Interleukin-15 signaling Extra-nuclear estrogen signaling Interleukin-2 signaling Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants +52 more

Sodium-coupled sulphate, di- and tri-carboxylate transporters

Bile secretion Folate transport and metabolism Organic anion transport

Metal ion SLC transporters

Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft

FoxO signaling pathway Cell cycle Endocytosis Cellular senescence Wnt signaling pathway TGF-beta signaling pathway Apelin signaling pathway Hippo signaling pathway Adherens junction Signaling pathways regulating pluripotency of stem cells Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Colorectal cancer Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Inflammatory bowel disease Diabetic cardiomyopathy Signaling by NODAL Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling FOXO-mediated transcription of cell cycle genes +34 more

FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Huntington disease Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +9 more

Myogenesis

Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors +1 more

PI3K-Akt signaling pathway Apelin signaling pathway Focal adhesion ECM-receptor interaction Toll-like receptor signaling pathway GnRH secretion Human papillomavirus infection Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation +10 more

EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Intestinal immune network for IgA production Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Hepatitis B Measles Human cytomegalovirus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Hypertrophic cardiomyopathy Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response +59 more

Endocrine resistance Leukocyte transendothelial migration GnRH signaling pathway Estrogen signaling pathway Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Proteoglycans in cancer Bladder cancer Diabetic cardiomyopathy Fluid shear stress and atherosclerosis Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling +15 more

Drug metabolism - other enzymes Phagosome Neutrophil extracellular trap formation Transcriptional misregulation in cancer Acute myeloid leukemia Neutrophil degranulation Events associated with phagocytolytic activity of PMN cells +4 more

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

HIF-1 signaling pathway p53 signaling pathway Cellular senescence Apelin signaling pathway Hippo signaling pathway Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications Chagas disease Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot +10 more

FoxO signaling pathway Cell cycle Endocytosis Cellular senescence Wnt signaling pathway TGF-beta signaling pathway Apelin signaling pathway Hippo signaling pathway Adherens junction Signaling pathways regulating pluripotency of stem cells Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Colorectal cancer Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Inflammatory bowel disease Diabetic cardiomyopathy Signaling by NODAL Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling FOXO-mediated transcription of cell cycle genes +34 more

FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Huntington disease Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +9 more

Elastic fibre formation Crosslinking of collagen fibrils

Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Lipid and atherosclerosis Fluid shear stress and atherosclerosis +4 more