Liver cirrhosis

Sodium/Proton exchangers Defective SLC9A9 causes autism 16 (AUTS16)

Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Glycosphingolipid biosynthesis - ganglio series Metabolic pathways Sialic acid metabolism +2 more

mRNA Splicing - Major Pathway

COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs

NGF-stimulated transcription

Polycomb repressive complex Formation of Incision Complex in GG-NER

Endocytosis Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events +2 more

Interaction With Cumulus Cells And The Zona Pellucida

Complement and coagulation cascades Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly +3 more

Endocrine resistance ABC transporters Bile secretion Cholesterol metabolism Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2 +4 more

ABC transporters Bile secretion PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1 +2 more

Renin-angiotensin system Renin secretion Chagas disease Coronavirus disease - COVID-19 Hypertrophic cardiomyopathy Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +4 more

Vascular smooth muscle contraction Apelin signaling pathway Motor proteins Relaxin signaling pathway Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription +3 more

RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway Measles Influenza A Coronavirus disease - COVID-19 C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling +5 more

Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling AMPK signaling pathway Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Salivary secretion Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events +8 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Renin-angiotensin system Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion Insulin resistance AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Pathways in cancer Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events +18 more

Th17 cell differentiation Cushing syndrome Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling +6 more

Porphyrin metabolism Metabolic pathways Biosynthesis of cofactors Heme biosynthesis Neutrophil degranulation +2 more

Thyroid hormone synthesis Platelet degranulation Recycling of bile acids and salts Heme biosynthesis Heme degradation Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transport of organic anions Post-translational protein phosphorylation HDL remodeling +7 more

HIF-1 signaling pathway Efferocytosis Cushing syndrome Pathways in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Regulation of gene expression by Hypoxia-inducible Factor PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling +10 more

MAPK signaling pathway Chemokine signaling pathway Endocytosis Hedgehog signaling pathway Dopaminergic synapse Olfactory transduction Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action GnRH secretion Morphine addiction Chemical carcinogenesis - receptor activation G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants +22 more

MAPK signaling pathway Chemokine signaling pathway Endocytosis Hedgehog signaling pathway Dopaminergic synapse Olfactory transduction Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action GnRH secretion Morphine addiction Chemical carcinogenesis - receptor activation G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants +21 more

Autophagy - other Autophagy - animal Longevity regulating pathway Longevity regulating pathway - multiple species Ferroptosis NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Shigellosis Macroautophagy Pink/Parkin Mediated Mitophagy Receptor Mediated Mitophagy +8 more

Platinum drug resistance Homologous recombination NF-kappa B signaling pathway FoxO signaling pathway Cell cycle p53 signaling pathway Apoptosis Cellular senescence Shigellosis Human papillomavirus infection Human T-cell leukemia virus 1 infection Human immunodeficiency virus 1 infection Transcriptional misregulation in cancer MicroRNAs in cancer DNA Damage/Telomere Stress Induced Senescence Regulation of HSF1-mediated heat shock response Autodegradation of the E3 ubiquitin ligase COP1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Caspase Activators and Caspases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Pexophagy +33 more

Platinum drug resistance Mineral absorption Ion transport by P-type ATPases

Regulation of ornithine decarboxylase (ODC)

Wnt signaling pathway TGF-beta signaling pathway Downregulation of TGF-beta receptor signaling

Efferocytosis Complement and coagulation cascades Alcoholic liver disease Prion disease Pertussis Chagas disease Staphylococcus aureus infection Coronavirus disease - COVID-19 Systemic lupus erythematosus Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade +9 more

Neuroactive ligand-receptor interaction Complement and coagulation cascades Neutrophil extracellular trap formation Regulation of actin cytoskeleton Alcoholic liver disease Prion disease Pertussis Staphylococcus aureus infection Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Systemic lupus erythematosus Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade +13 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NOD-like receptor signaling pathway IL-17 signaling pathway TNF signaling pathway AGE-RAGE signaling pathway in diabetic complications Yersinia infection Chagas disease Malaria Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Rheumatoid arthritis Lipid and atherosclerosis Fluid shear stress and atherosclerosis Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling +18 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway TNF signaling pathway Prion disease Epithelial cell signaling in Helicobacter pylori infection Shigellosis Chagas disease Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Rheumatoid arthritis Lipid and atherosclerosis Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling +16 more

Apelin signaling pathway Hippo signaling pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription +1 more

MAPK signaling pathway NF-kappa B signaling pathway Phagosome Toll-like receptor signaling pathway Hematopoietic cell lineage Alcoholic liver disease Shigellosis Salmonella infection Pertussis Legionellosis Amoebiasis Tuberculosis Transcriptional misregulation in cancer Acute myeloid leukemia Lipid and atherosclerosis ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation +29 more

Virion - Hepatitis viruses Hematopoietic cell lineage Platelet degranulation Acrosome Reaction and Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin +2 more

Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway Cell adhesion molecules Adherens junction Bacterial invasion of epithelial cells Pathways in cancer Endometrial cancer Thyroid cancer Melanoma Bladder cancer Gastric cancer Degradation of the extracellular matrix Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells +15 more

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +4 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Cholinergic synapse Taste transduction Regulation of actin cytoskeleton Insulin secretion Salivary secretion Gastric acid secretion Pancreatic secretion Alzheimer disease Pathways of neurodegeneration - multiple diseases Muscarinic acetylcholine receptors G alpha (q) signalling events +10 more

Rap1 signaling pathway Neuroactive ligand-receptor interaction Thermogenesis Retrograde endocannabinoid signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events +3 more

Neuroactive ligand-receptor interaction Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events

ABC transporters Bile secretion PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1 +2 more

Thyroid hormone synthesis Platelet degranulation Recycling of bile acids and salts Heme biosynthesis Heme degradation Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transport of organic anions Post-translational protein phosphorylation HDL remodeling +7 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway TNF signaling pathway Prion disease Epithelial cell signaling in Helicobacter pylori infection Shigellosis Chagas disease Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Rheumatoid arthritis Lipid and atherosclerosis Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling +16 more