Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
LIVER CIRRHOSIS	C0023890 MESH:D008103	COL1A1	Unknown	21863215 24239723 24321339 26396155 32659284	CTD, Disgenet	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +26 more
		COL1A2	Unknown	26396155	CTD, Disgenet	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +27 more
		COL3A1	Unknown	11167689 15787813 16679477 1880254 2566230	CTD, Disgenet	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
		COL5A2	Unknown	26396155	CTD, Disgenet	Cytoskeleton in muscle cells Protein digestion and absorption Collagen degradation +10 more
		COMMD1	Unknown	17919502	CTD, Disgenet	Neddylation
		CP	Unknown	25226513 26396155	CTD, Disgenet	Porphyrin metabolism Ferroptosis Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) +5 more
		CTNNB1	Unknown	21047994	CTD, Disgenet	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		CXCL14	Unknown	33069761	CTD, Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway
		CYBA	Unknown	25226513	CTD, Disgenet	Phagosome Osteoclast differentiation Neutrophil extracellular trap formation +15 more
		CYP1A2	Unknown	27565560	CTD, Disgenet	Steroid hormone biosynthesis Caffeine metabolism Tryptophan metabolism +15 more
		CYP27A1	Unknown	24381012	CTD, Disgenet	Primary bile acid biosynthesis Metabolic pathways PPAR signaling pathway +6 more
		CYP2R1	Unknown	24381012	CTD, Disgenet	Steroid biosynthesis Metabolic pathways Vitamin D (calciferol) metabolism +2 more
		CYP4A11	Unknown	36368619	CTD	PPARA activates gene expression Fatty acids Miscellaneous substrates +3 more
		DHCR7	Unknown	24381012	CTD, Disgenet	Steroid biosynthesis Metabolic pathways Activation of gene expression by SREBF (SREBP) +2 more
		DRD4	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Dopaminergic synapse +2 more
		F2	Unknown	10216089	CTD, Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Complement and coagulation cascades +17 more
		F2R	Unknown	21037076	CTD, Disgenet	Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway +12 more
		F3	Unknown	10216089	CTD, Disgenet	Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications Extrinsic Pathway of Fibrin Clot Formation +1 more
		F5	Unknown	18485088	CTD, Disgenet	Complement and coagulation cascades Platelet degranulation Common Pathway of Fibrin Clot Formation +4 more
		FARSB	Unknown	—	Disgenet	Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation
		FBN1	Unknown	26396155	CTD, Disgenet	TGF-beta signaling pathway Cytoskeleton in muscle cells Degradation of the extracellular matrix +5 more
		FGF19	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +19 more
		FGF2	Unknown	17093919	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +56 more
		FGF7	Unknown	17692400	CTD, Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +21 more
		FGFR2	Unknown	17692400	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FGFR4	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		FLT1	Unknown	11981751	CTD, Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +8 more
		FOCAD	Unknown	35864190	CTD, Disgenet	—
		FOXO3	Unknown	33372984	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway FoxO signaling pathway +26 more
		GSTM1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTT1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		HDAC2	Unknown	27396813	CTD, Disgenet	ATP-dependent chromatin remodeling Polycomb repressive complex Cell cycle +26 more
		HFE	Unknown	—	Disgenet	TGF-beta signaling pathway Transferrin endocytosis and recycling
		HGF	Unknown	17097021	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIF1A	Unknown	36126797	CTD, Disgenet	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HLA-DPA1	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQA1	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB1	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HSD11B2	Unknown	15199296	CTD, Disgenet	Steroid hormone biosynthesis Metabolic pathways Aldosterone-regulated sodium reabsorption +1 more
		ICAM1	Unknown	—	Disgenet	NF-kappa B signaling pathway Cell adhesion molecules Natural killer cell mediated cytotoxicity +19 more
		IDO2	Unknown	32289347	CTD, Disgenet	Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors +2 more
		IFNA1	Unknown	18665156	CTD, Disgenet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Necroptosis +26 more
		IFNA2	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Necroptosis +26 more
		IFNG	Unknown	—	Disgenet	Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway +33 more
		IFNL3	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Interleukin-20 family signaling
		IGF1	Unknown	38685136	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +35 more
		IGF1R	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +31 more
		IGFBP1	Unknown	26396155	CTD, Disgenet	ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more
		IGFBP2	Unknown	26396155	CTD, Disgenet	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
		IL10	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway +25 more
LIVER CIRRHOSIS, ALCOHOLIC	C0023891 MESH:D008104	COL3A1	Unknown	23274713	CTD, Disgenet	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
LIVER CIRRHOSIS, BILIARY	MESH:D008105	HIF1A	Unknown	22271822	CTD	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
LIVER CIRRHOSIS, BILIARY	MESH:D008105	IGFBP1	Unknown	18422935	CTD	ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more

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Liver cirrhosis

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