Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
INFLAMMATORY BOWEL DISEASE	EFO_0003767	INSL4	Unknown	39792054	GWAS catalog	—
		INSL6	Unknown	39792054	GWAS catalog	—
		INTS11	Unknown	23128233 26192919 28067908	GWAS catalog	RNA polymerase II transcribes snRNA genes
		IP6K2	Unknown	39792054	GWAS catalog	Phosphatidylinositol signaling system Synthesis of IPs in the nucleus Interferon alpha/beta signaling
		IPMK	Unknown	21102463 23128233 26192919 28067908 37156999	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +1 more
		IPPK	Unknown	37156999	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +2 more
		IQCH	Unknown	38154582	GWAS catalog	—
		IRF1	Unknown	21102463 26192919 39792054	GWAS catalog	C-type lectin receptor signaling pathway TNF signaling pathway Prolactin signaling pathway +5 more
		IRF2BP2	Unknown	37156999	GWAS catalog	—
		IRF3	Unknown	36753304	GWAS catalog	Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway +30 more
		IRF4	Unknown	26192919	GWAS catalog	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		IRF5	Unknown	26192919 33608531 37156999 37965154	GWAS catalog	Toll-like receptor signaling pathway Interferon gamma signaling Interferon alpha/beta signaling
		IRF6	Unknown	28067908 37156999	GWAS catalog	Interferon gamma signaling Interferon alpha/beta signaling
		IRGM	Unknown	17554261 17554300 18587394 21102463 23128233 26192919 28067908 37156999 37523193 38616254 39792054	GWAS catalog	NOD-like receptor signaling pathway Toxoplasmosis
		ITGA4	Unknown	28067908 33608531 36753304 37156999	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +16 more
		ITGAV	Unknown	37156999	GWAS catalog	Hormone signaling Phagosome Efferocytosis +26 more
		ITGB3	Unknown	37156999	GWAS catalog	Virion - Herpesvirus Rap1 signaling pathway Hormone signaling +39 more
		ITGB8	Unknown	28067908 37156999	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +9 more
		ITLN1	Unknown	18587394 23128233 26192919 28067908	GWAS catalog	Antimicrobial peptides
		JAK2	Unknown	18587394 21102463 23128233 23266558 26192919 28067908 35232999 37156999 37965154 39024449 39792054	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAZF1	Unknown	23128233 26192919 37156999	GWAS catalog	—
		KAT2A	Unknown	26278503	GWAS catalog	Viral life cycle - HIV-1 Notch signaling pathway Thyroid hormone signaling pathway +12 more
		KCNQ4	Unknown	36077729	GWAS catalog	Cholinergic synapse Voltage gated Potassium channels
		KEAP1	Unknown	39792054	GWAS catalog	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIF21B	Unknown	18587394 39792054	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KIF3B	Unknown	26192919	GWAS catalog	Motor proteins MHC class II antigen presentation Intraflagellar transport +2 more
		KIR3DL2	Unknown	26192919	GWAS catalog	Antigen processing and presentation Natural killer cell mediated cytotoxicity Graft-versus-host disease +1 more
		KLF6	Unknown	17554300	GWAS catalog	—
		KPNA7	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	Nucleocytoplasmic transport Influenza A Chemical carcinogenesis - receptor activation +2 more
		KSR1	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	Ras signaling pathway C-type lectin receptor signaling pathway Tuberculosis +8 more
		LACC1	Unknown	18587394 21102463 23128233 26192919 28067908 37156999 37523193	GWAS catalog	Purine metabolism Cysteine and methionine metabolism Metabolic pathways +1 more
		LAMB1	Unknown	39792054	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +9 more
		LCAT	Unknown	22412388	GWAS catalog	Glycerophospholipid metabolism Cholesterol metabolism HDL remodeling
		LILRB3	Unknown	37156999 37523193	GWAS catalog	Osteoclast differentiation B cell receptor signaling pathway
		LITAF	Unknown	26192919 37156999 37262302	GWAS catalog	Lysosome
		LPP	Unknown	28067908 37156999	GWAS catalog	—
		LPXN	Unknown	23128233 37156999	GWAS catalog	—
		LRRC3C	Unknown	39792054	GWAS catalog	—
		LRRK1	Unknown	37156999	GWAS catalog	—
		LRRK2	Unknown	18587394 26192919 28067908 37262302	GWAS catalog	Parkinson disease Pathways of neurodegeneration - multiple diseases PTK6 promotes HIF1A stabilization
		LSAMP	Unknown	35232999	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		LSP1	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	C-type lectin receptor signaling pathway Tuberculosis
		LTA	Unknown	21102463 37262302	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway +7 more
		LTBR	Unknown	26192919 28067908 37156999	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway +6 more
		LYZ	Unknown	37156999	GWAS catalog	Salivary secretion Neutrophil degranulation Antimicrobial peptides +1 more
		MACROD1	Unknown	38154582	GWAS catalog	—
		MACROD2	Unknown	37156999	GWAS catalog	—
		MAD1L1	Unknown	38154582	GWAS catalog	Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation +8 more
		MAFB	Unknown	37156999	GWAS catalog	Parathyroid hormone synthesis, secretion and action
		MAGI3	Unknown	28067908	GWAS catalog	Rap1 signaling pathway
INFLAMMATORY BOWEL DISEASE 14	C2677100 MESH:C567383 MONDO:0012832	IRF5	Unknown	—	CTD, ClinVar, Disgenet	Toll-like receptor signaling pathway Interferon gamma signaling Interferon alpha/beta signaling
INFLAMMATORY BOWEL DISEASE 19	C2677079 MESH:C567372 MONDO:0012845	IRGM	Unknown	—	CTD, ClinVar, Disgenet	NOD-like receptor signaling pathway Toxoplasmosis
INFLAMMATORY BOWEL DISEASES	C0021390 MESH:D015212	IRGM	Unknown	26192919	CTD, Disgenet	NOD-like receptor signaling pathway Toxoplasmosis
		ITGA4	Unknown	28067908	CTD, Disgenet	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +16 more
		ITGB8	Unknown	28067908	CTD, Disgenet	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +9 more

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Inflammatory bowel disease

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