Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
INFLAMMATORY BOWEL DISEASE	EFO_0003767	HLA-C	Unknown	37377963	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-DMA	Unknown	37377963 38154582	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +21 more
		HLA-DMB	Unknown	38154582	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DOA	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DOB	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DPA1	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQA1	Unknown	18758464 23850713 26192919 26891255 28008999 28067908 36077729 37156999 37377963 37965154 38102678	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQA2	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB1	Unknown	17554300 26192919 26891255 30500874 32581322 37377963 37965154	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB2	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB3	Unknown	23266558 37377963 37965154	GWAS catalog	—
		HLA-DRA	Unknown	28506689 37377963 37965154	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB1	Unknown	18758464 23850713 26891255 36077729 37156999 37377963 37965154 38102678	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB5	Unknown	37377963	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLX	Unknown	38102678	GWAS catalog	—
		HMGN4	Unknown	37377963	GWAS catalog	—
		HORMAD1	Unknown	37156999	GWAS catalog	—
		HORMAD2	Unknown	19915574 21102463 23128233 26192919 28067908 37156999 39792054	GWAS catalog	—
		HSPA1L	Unknown	37377963	GWAS catalog	Spliceosome MAPK signaling pathway Protein processing in endoplasmic reticulum +13 more
		HSPA6	Unknown	39792054	GWAS catalog	Spliceosome MAPK signaling pathway Protein processing in endoplasmic reticulum +11 more
		HUNK	Unknown	32581322	GWAS catalog	—
		ICOSLG	Unknown	39792054	GWAS catalog	Cell adhesion molecules Intestinal immune network for IgA production Costimulation by the CD28 family
		IFFO2	Unknown	35232999	GWAS catalog	—
		IFIH1	Unknown	23128233 26192919 37156999 37262302	GWAS catalog	RIG-I-like receptor signaling pathway Hepatitis B Measles +11 more
		IFNGR2	Unknown	22936669 23128233 26192919 28067908 37156999	GWAS catalog	Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis +16 more
		IFT81	Unknown	37156999	GWAS catalog	Intraflagellar transport
		IKZF1	Unknown	18587394 21102463 23128233 26192919 28067908 37156999 37262302 37523193 38616254	GWAS catalog	—
		IKZF3	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	—
		IL10	Unknown	21102463 23128233 26192919 28008999 28067908 33608531 37156999 37377963 37965154 39792054	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway +25 more
		IL12RB2	Unknown	35232999 37965154 39792054	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th1 and Th2 cell differentiation +4 more
		IL17REL	Unknown	37156999	GWAS catalog	—
		IL18R1	Unknown	26192919 28067908 37156999 38102678 39792054	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor TNF signaling pathway +3 more
		IL18RAP	Unknown	21102463 23128233 26192919 37156999 39792054	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Inflammatory bowel disease +1 more
		IL19	Unknown	39792054	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway +1 more
		IL1R1	Unknown	26192919 39792054	GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway +12 more
		IL1R2	Unknown	26192919 39792054	GWAS catalog	Cytokine-cytokine receptor interaction Hematopoietic cell lineage Amoebiasis +6 more
		IL1RL1	Unknown	28067908 38102678 39792054	GWAS catalog	Cytokine-cytokine receptor interaction PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +1 more
		IL2	Unknown	28067908 37156999	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway +21 more
		IL20	Unknown	39792054	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway +1 more
		IL21	Unknown	37156999	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL21R	Unknown	37156999	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IL23R	Unknown	17435756 17447842 17554300 18587394 18758464 20570966 21102463 22293688 22412388 22936669 23128233 23850713 26192919 28008999 28067908 30500874 32581322 33608531 37156999 37377963 37965154 39024449 39792054	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +4 more
		IL27	Unknown	23128233 26192919 28067908 30500874 32581322 35512355 37156999 37523193 39792054	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +1 more
		IL2RA	Unknown	21102463 23128233 26192919 28067908 37156999 37262302	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis +12 more
		IL3	Unknown	22412388	GWAS catalog	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Apoptosis +11 more
		IL4R	Unknown	37156999	GWAS catalog	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +6 more
		IMPG2	Unknown	28067908 37156999	GWAS catalog	—
		INAVA	Unknown	21102463 23128233 26192919 28067908 33608531 36753304 37156999 37965154 38154582 39792054	GWAS catalog	—
		INKA2	Unknown	30500874	GWAS catalog	—
		INPP5E	Unknown	39792054	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +2 more
INFLAMMATORY BOWEL DISEASE 17	C2677091 MESH:C567378 MONDO:0012840	IL23R	Unknown	—	CTD, ClinVar, Disgenet	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +4 more
INFLAMMATORY BOWEL DISEASE 29	C4748083 MONDO:0054849	INAVA	Unknown	—	ClinVar, Disgenet	—
INFLAMMATORY BOWEL DISEASES	C0021390 MESH:D015212	IL10	Unknown	23291587 27783946 28411859	CTD, Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor FoxO signaling pathway +25 more
		IL18RAP	Unknown	21983784	CTD, Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Inflammatory bowel disease +1 more
		IL19	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway +1 more
		IL23R	Unknown	21983784 23291587 26192919	CTD, Disgenet	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +4 more
		INAVA	Unknown	21983784	CTD, Disgenet	—

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Inflammatory bowel disease

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