Subtype of: Breast cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HER2 positive breast carcinoma	MONDO_0006244	SETD2	Unknown	25591616 29807833 25850943	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SETDB1	Unknown	27406316	Open Targets	Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells +1 more
		SF3B1	Unknown	25591616	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SFRP4	Unknown	27406316	Open Targets	Wnt signaling pathway
		SGK1	Unknown	27406316 22722202	Open Targets	FoxO signaling pathway Efferocytosis mTOR signaling pathway +6 more
		SH3GL1	Unknown	27406316	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		SKI	Unknown	27406316	Open Targets	TGF-beta signaling pathway Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity
		SMAD2	Unknown	30205045	Open Targets	Cell cycle Endocytosis Cellular senescence +30 more
		SMAD4	Unknown	25591616 26527317 22722201 30205045 22722202	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	27406316	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCD1	Unknown	22722201	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SMO	Unknown	38895905	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SNX29	Unknown	27406316	Open Targets	—
		SOS1	Unknown	28027327	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SPEN	Unknown	27406316 28027327 26297734 22722202	Open Targets	Notch signaling pathway
		SRSF2	Unknown	27406316	Open Targets	Spliceosome Herpes simplex virus 1 infection Transport of Mature mRNA derived from an Intron-Containing Transcript +4 more
		STAG2	Unknown	22722202	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAT3	Unknown	20668451 22722202	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STAT5B	Unknown	27406316	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more
		STAT6	Unknown	27406316	Open Targets	Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation +7 more
		STK11	Unknown	26527317 30062102	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		SUFU	Unknown	20668451 25850943	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		TAL1	Unknown	27406316	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		TBX3	Unknown	27406316 25850943	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TCEA1	Unknown	22722202	Open Targets	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex +5 more
		TCF12	Unknown	27406316 28027327 22722202	Open Targets	Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription
		TCF3	Unknown	20668451	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TET1	Unknown	27406316 28027327 20668451	Open Targets	—
		TET2	Unknown	22722202 30062102	Open Targets	—
		TFE3	Unknown	27406316 20668451	Open Targets	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma
		TFG	Unknown	22722202	Open Targets	Pathways in cancer Thyroid cancer COPII-mediated vesicle transport
		TGFBR2	Unknown	27406316	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TNC	Unknown	22722201	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TNRC18	Unknown	27406316 28027327 22722202	Open Targets	—
		TP53	Unknown	27406316 38895905 22722201 30062102 33004031 21512767 30205045 26527317 19372580 25850943 28027327 21493686 27135926 23601657 29807833 25757876 25591616 20668451 22722202 38970069	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	22722202	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPM3	Unknown	27406316	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPM4	Unknown	22722202	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +5 more
		TPR	Unknown	30062102	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRAF7	Unknown	20668451	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM24	Unknown	22722202	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIM27	Unknown	27406316	Open Targets	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
		TRIM33	Unknown	21493686 22722201	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRIP11	Unknown	27406316 25591616	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	27406316 28027327 22722201	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC1	Unknown	27406316	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	27406316 21493686 30205045	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		UBR5	Unknown	27406316 20668451 22722202	Open Targets	Ubiquitin mediated proteolysis
		USP6	Unknown	27406316	Open Targets	—
		USP8	Unknown	27406316	Open Targets	Mitophagy - animal Endocytosis Cushing syndrome +4 more

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Her2 positive breast carcinoma

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