Subtype of: Breast cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HER2 positive breast carcinoma	MONDO_0006244	IDH2	Unknown	25591616	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKBKB	Unknown	25591616	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IKZF1	Unknown	27406316 30205045	Open Targets	—
		IRF4	Unknown	30062102	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		IRS4	Unknown	22722202	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		ITGAV	Unknown	27406316	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		ITK	Unknown	27406316	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	27406316 20668451 29807833	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	27406316 25591616 38970069	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	28027327 20668451	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KAT6A	Unknown	27406316	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT6B	Unknown	27406316 30062102	Open Targets	HATs acetylate histones
		KAT7	Unknown	27406316	Open Targets	HATs acetylate histones
		KDM5C	Unknown	22722202 30205045	Open Targets	HDMs demethylate histones
		KEAP1	Unknown	25591616 28027327	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIAA1549	Unknown	27406316	Open Targets	Signaling by BRAF and RAF fusions
		KIF5B	Unknown	21493686 22722202	Open Targets	Endocytosis Dopaminergic synapse Motor proteins +12 more
		KIT	Unknown	26527317 30062102	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KLF4	Unknown	22722202	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KMT2A	Unknown	20668451 22722201 25850943	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	27406316 22722201 30062102 30205045 28027327 22722202	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	27406316 22722202 30062102 30205045	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	20668451	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KTN1	Unknown	20668451	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	27406316	Open Targets	—
		LATS1	Unknown	20668451 30205045	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	20668451	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LHFPL6	Unknown	27406316	Open Targets	—
		LMNA	Unknown	27406316	Open Targets	Apoptosis Cytoskeleton in muscle cells Hypertrophic cardiomyopathy +8 more
		LOC100506403	Unknown	25850943	Open Targets	—
		LOC124905021	Unknown	21493686	Open Targets	—
		LRP1B	Unknown	27406316 22722202	Open Targets	—
		LYN	Unknown	27406316	Open Targets	Chemokine signaling pathway NF-kappa B signaling pathway Platelet activation +36 more
		MAML2	Unknown	20668451 22722201	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP2K1	Unknown	29807833	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP2K4	Unknown	27406316 22722202 25850943	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	28027327 25850943	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAPK1	Unknown	22722202	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MB21D2	Unknown	28027327 22722202	Open Targets	—
		MECOM	Unknown	27406316 22722202	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MED12	Unknown	27406316	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEN1	Unknown	27406316 28027327	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	20668451	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MLH1	Unknown	20668451 26527317	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT10	Unknown	27406316	Open Targets	—
		MN1	Unknown	25591616	Open Targets	—
		MNX1	Unknown	27406316	Open Targets	Maturity onset diabetes of the young
		MPL	Unknown	27406316	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MSH6	Unknown	20668451	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	28027327 20668451	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more

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Her2 positive breast carcinoma

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