Hepatocellular carcinoma

Rho GTPase cycle MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins +1 more

Homologous recombination

Th17 cell differentiation Estrogen signaling pathway Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Transcriptional regulation of granulopoiesis +6 more

Endocrine resistance Cell cycle Cellular senescence Cushing syndrome Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Pancreatic cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry +30 more

Thyroid hormone signaling pathway Oxytocin signaling pathway Kaposi sarcoma-associated herpesvirus infection

Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of expression of SLITs and ROBOs +3 more

EGFR tyrosine kinase inhibitor resistance Ribosome HIF-1 signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Apelin signaling pathway Thermogenesis Insulin signaling pathway Coronavirus disease - COVID-19 Proteoglycans in cancer L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +19 more

MAPK signaling pathway Oocyte meiosis mTOR signaling pathway Thermogenesis Long-term potentiation Neurotrophin signaling pathway Progesterone-mediated oocyte maturation Insulin resistance Yersinia infection Chemical carcinogenesis - receptor activation ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation Gastrin-CREB signalling pathway via PKC and MAPK +13 more

Purine metabolism Pyrimidine metabolism Glutathione metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism Interconversion of nucleotide di- and triphosphates +4 more

Purine metabolism Pyrimidine metabolism Glutathione metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism p53 signaling pathway Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6 +7 more

Wnt signaling pathway Regulation of FZD by ubiquitination RUNX1 regulates transcription of genes involved in WNT signaling

Olfactory Signaling Pathway

Th1 and Th2 cell differentiation Epstein-Barr virus infection Binding of TCF/LEF:CTNNB1 to target gene promoters RUNX3 regulates CDKN1A transcription RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates WNT signaling RUNX3 regulates YAP1-mediated transcription RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF RUNX3 regulates BCL2L11 (BIM) transcription +9 more

Regulation of cholesterol biosynthesis by SREBP (SREBF)

Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism PPAR signaling pathway AMPK signaling pathway Alcoholic liver disease Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +6 more

Complement and coagulation cascades Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation +4 more

Platelet degranulation

Cell cycle p53 signaling pathway Aldosterone-regulated sodium reabsorption Activation of BAD and translocation to mitochondria RHO GTPases activate PKNs TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors +6 more

Wnt signaling pathway

Endocytosis EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +2 more

Hedgehog signaling pathway Axon guidance Pathways in cancer Proteoglycans in cancer Basal cell carcinoma Gastric cancer Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Release of Hh-Np from the secreting cell Ligand-receptor interactions Activation of SMO HHAT G278V abrogates palmitoylation of Hh-Np +9 more

Glucagon signaling pathway

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +3 more

FoxO signaling pathway Cell cycle Ubiquitin mediated proteolysis mTOR signaling pathway Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Small cell lung cancer APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Antigen processing: Ubiquitination & Proteasome degradation +13 more

Bile secretion Choline metabolism in cancer Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport +4 more

Mineral absorption Chemical carcinogenesis - reactive oxygen species Multifunctional anion exchangers

HIF-1 signaling pathway Efferocytosis Insulin secretion Thyroid hormone signaling pathway Adipocytokine signaling pathway Glucagon signaling pathway Insulin resistance Bile secretion Human T-cell leukemia virus 1 infection Pathways in cancer Renal cell carcinoma Central carbon metabolism in cancer Diabetic cardiomyopathy Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis +15 more

Insulin secretion Prolactin signaling pathway Glucagon signaling pathway Type II diabetes mellitus Insulin resistance Maturity onset diabetes of the young Carbohydrate digestion and absorption Central carbon metabolism in cancer Cellular hexose transport Regulation of insulin secretion Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) Intestinal hexose absorption +9 more

Thyroid hormone synthesis Thyroxine biosynthesis Organic anion transporters Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) +1 more

Axon guidance Signaling by ROBO receptors Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of expression of SLITs and ROBOs +2 more

Adherens junction Regulation of PTEN gene transcription

JAK-STAT signaling pathway Insulin signaling pathway Prolactin signaling pathway Type II diabetes mellitus Growth hormone synthesis, secretion and action Interleukin-7 signaling Neddylation +4 more

Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway TNF signaling pathway Insulin signaling pathway Prolactin signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Growth hormone synthesis, secretion and action Hepatitis C Influenza A Herpes simplex virus 1 infection Interleukin-6 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 Neddylation Interferon alpha/beta signaling Antigen processing: Ubiquitination & Proteasome degradation +19 more

Peroxisome Longevity regulating pathway - multiple species Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Platelet degranulation Detoxification of Reactive Oxygen Species Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +8 more

FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Huntington disease Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +9 more

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +3 more

Translesion Synthesis by POLH

AMPK signaling pathway Insulin signaling pathway Insulin resistance Non-alcoholic fatty liver disease Alcoholic liver disease RORA activates gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +7 more

Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination +1 more

Transcriptional misregulation in cancer

Efferocytosis Hyaluronan uptake and degradation Scavenging by Class H Receptors

Chemokine signaling pathway Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Prolactin signaling pathway Thyroid hormone signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Leishmaniasis Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Pancreatic cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Interleukin-6 signaling ISG15 antiviral mechanism Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-9 signaling NOTCH3 Intracellular Domain Regulates Transcription Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Regulation of IFNA signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants +44 more

Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation Hepatitis B Pathways in cancer Inflammatory bowel disease Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling +9 more

Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation Hepatitis B Pathways in cancer Inflammatory bowel disease Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling +9 more