Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HEART FAILURE	EFO_0003144 C0018801 MESH:D006333	NPAS3	Unknown	40195560	GWAS catalog	—
		NPC1	Unknown	33910581 36376295 40195560 41184235	GWAS catalog	Virion - Ebolavirus, Lyssavirus and Morbillivirus Lysosome Cholesterol metabolism +1 more
		NPPA	Unknown	11136700 16101196 1647690 8112904	CTD, Disgenet	cGMP-PKG signaling pathway cAMP signaling pathway HIF-1 signaling pathway +11 more
		NPPB	Unknown	11136700 11279304 12628948 15732037 15860969 16101196 16333235 16360360 16762801 16777915 19650993 24535859 29959987	CTD, Disgenet	cGMP-PKG signaling pathway Hormone signaling Vascular smooth muscle contraction +1 more
		NPR1	Unknown	20881240	CTD, Disgenet	Purine metabolism Metabolic pathways cGMP-PKG signaling pathway +9 more
		NR3C1	Unknown	40195560	GWAS catalog	Neuroactive ligand-receptor interaction HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway +2 more
		NR3C2	Unknown	15722665 21321305	CTD, Disgenet	Aldosterone-regulated sodium reabsorption HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway +1 more
		NRBP1	Unknown	27790247	GWAS catalog	Nuclear Receptor transcription pathway
		NRG1	Unknown	19801490	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NRIP1	Unknown	22503866	CTD, Disgenet	SUMOylation of transcription cofactors Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +1 more
		NRXN3	Unknown	40195560	GWAS catalog	Cell adhesion molecules Neurexins and neuroligins
		OGDHL	Unknown	36071497	CTD, Disgenet	Citrate cycle (TCA cycle) Lipoic acid metabolism Metabolic pathways +2 more
		OLR1	Unknown	22352330	CTD, Disgenet	PPAR signaling pathway Phagosome Lipid and atherosclerosis +2 more
		OR13D1	Unknown	40195560	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		OR2A2	Unknown	36376295 40195560 41184235	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		PAMR1	Unknown	28751527	CTD, Disgenet	—
		PAQR5	Unknown	41184235	GWAS catalog	Chemical carcinogenesis - receptor activation
		PCK1	Unknown	26670611	CTD, Disgenet	Glycolysis / Gluconeogenesis Citrate cycle (TCA cycle) Pyruvate metabolism +13 more
		PDE4B	Unknown	37429843	GWAS catalog	Purine metabolism Metabolic pathways cAMP signaling pathway +3 more
		PDGFRA	Unknown	28347583	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDPK1	Unknown	19429709	CTD, Disgenet	Platinum drug resistance PPAR signaling pathway FoxO signaling pathway +39 more
		PEBP1	Unknown	26670611	CTD, Disgenet	MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants +4 more
		PGR	Unknown	40195560	GWAS catalog	Oocyte meiosis Progesterone-mediated oocyte maturation Estrogen signaling pathway +7 more
		PHACTR1	Unknown	37429843	GWAS catalog	—
		PHF6	Unknown	—	Disgenet	ATP-dependent chromatin remodeling
		PHIP	Unknown	37429843	GWAS catalog	—
		PIK3CG	Unknown	12963636	CTD, Disgenet	Inositol phosphate metabolism Metabolic pathways cGMP-PKG signaling pathway +15 more
		PITX2	Unknown	31919418 34594039 36376295 36777996 37429843 40195560	GWAS catalog	TGF-beta signaling pathway TFAP2 (AP-2) family regulates transcription of other transcription factors
		PKD1	Unknown	36376295	GWAS catalog	VxPx cargo-targeting to cilium
		PLAT	Unknown	22352330	CTD, Disgenet	Apelin signaling pathway Complement and coagulation cascades Transcriptional misregulation in cancer +4 more
		PLCG1	Unknown	27790247	GWAS catalog	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLPP3	Unknown	40195560	GWAS catalog	Glycerolipid metabolism Glycerophospholipid metabolism Ether lipid metabolism +7 more
		PNKP	Unknown	40195560	GWAS catalog	Base excision repair APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
		PNMT	Unknown	37429843	GWAS catalog	Tyrosine metabolism Metabolic pathways Catecholamine biosynthesis
		PNPLA2	Unknown	35218467	CTD, Disgenet	Glycerolipid metabolism Metabolic pathways Thermogenesis +4 more
		POC1B	Unknown	40195560	GWAS catalog	—
		POC5	Unknown	27790247	GWAS catalog	—
		POLK	Unknown	27790247	GWAS catalog	Fanconi anemia pathway Epstein-Barr virus infection Pathways in cancer +21 more
		POLR1F	Unknown	27790247	GWAS catalog	RNA polymerase
		POM121C	Unknown	36376295 37429843 41184235	GWAS catalog	Nucleocytoplasmic transport Amyotrophic lateral sclerosis
		POMC	Unknown	3026683 8277081	CTD, Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +18 more
		PON1	Unknown	26670611	CTD, Disgenet	Synthesis of 5-eicosatetraenoic acids
		POR	Unknown	36071497	CTD, Disgenet	Cytochrome P450 - arranged by substrate type
		PPARG	Unknown	26670611	CTD, Disgenet	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PPARGC1A	Unknown	19808358 22503866	CTD, Disgenet	AMPK signaling pathway Longevity regulating pathway Apelin signaling pathway +12 more
		PPM1G	Unknown	27790247	GWAS catalog	—
		PPM1K	Unknown	36071497	CTD, Disgenet	Branched-chain amino acid catabolism
		PPP1R1A	Unknown	20071777	CTD, Disgenet	Adrenergic signaling in cardiomyocytes Long-term potentiation
		PPP2R3A	Unknown	40195560	GWAS catalog	mRNA surveillance pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway +5 more
		PRAM1	Unknown	40195560	GWAS catalog	—
HEART FAILURE, DIASTOLIC	C1135196 MESH:D054144	NPPA	Unknown	29556499	CTD, Disgenet	cGMP-PKG signaling pathway cAMP signaling pathway HIF-1 signaling pathway +11 more
HEART FAILURE, SYSTOLIC	C1135191	NPPB	Unknown	—	Disgenet	cGMP-PKG signaling pathway Hormone signaling Vascular smooth muscle contraction +1 more

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Heart failure

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