Gastric adenoma

mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Signaling by cytosolic PDGFRA and PDGFRB fusion proteins +4 more

mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1

MAPK signaling pathway Focal adhesion Salmonella infection Proteoglycans in cancer Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response +6 more

MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway Hematopoietic cell lineage Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Central carbon metabolism in cancer PI3K Cascade RAF/MAP kinase cascade FLT3 Signaling +8 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Focal adhesion Pathways in cancer Breast cancer VEGF binds to VEGFR leading to receptor dimerization +6 more

FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Insulin signaling pathway Thyroid hormone signaling pathway Glucagon signaling pathway Insulin resistance AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Shigellosis Human papillomavirus infection Pathways in cancer Transcriptional misregulation in cancer Prostate cancer AKT phosphorylates targets in the nucleus AKT-mediated inactivation of FOXO1A Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes +23 more

MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells

mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Transcriptional misregulation in cancer mRNA Splicing - Major Pathway +3 more

Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action Inflammatory bowel disease Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Factors involved in megakaryocyte development and platelet production +6 more

cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription +5 more

Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling Vascular smooth muscle contraction Gap junction Cholinergic synapse Long-term depression Insulin secretion GnRH signaling pathway Aldosterone synthesis and secretion Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion Cushing syndrome Growth hormone synthesis, secretion and action Chagas disease Amoebiasis Human cytomegalovirus infection Human immunodeficiency virus 1 infection Pathways in cancer Acetylcholine regulates insulin secretion G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) +23 more

Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Gap junction Platelet activation Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse Dopaminergic synapse Long-term depression Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion Cushing syndrome Growth hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Alzheimer disease Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Yersinia infection Chagas disease African trypanosomiasis Amoebiasis Human cytomegalovirus infection Human immunodeficiency virus 1 infection Pathways in cancer Acetylcholine regulates insulin secretion G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) +52 more

Endocrine resistance Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway Phospholipase D signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Gap junction Platelet activation Circadian entrainment Thermogenesis Glutamatergic synapse Serotonergic synapse Dopaminergic synapse Long-term depression Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Ovarian steroidogenesis Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Glucagon signaling pathway Regulation of lipolysis in adipocytes Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Vasopressin-regulated water reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Bile secretion Parkinson disease Cocaine addiction Amphetamine addiction Morphine addiction Alcoholism Vibrio cholerae infection Chagas disease Amoebiasis Human cytomegalovirus infection Human papillomavirus infection Pathways in cancer Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production +58 more

Intra-Golgi traffic

Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport +9 more

A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Release of Hh-Np from the secreting cell Retinoid metabolism and transport +7 more

Folate biosynthesis Metabolic pathways Biosynthesis of cofactors GABAergic synapse Molybdenum cofactor biosynthesis +2 more

Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Long-term potentiation Glutamatergic synapse Dopaminergic synapse Alzheimer disease Amyotrophic lateral sclerosis Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Nicotine addiction Alcoholism Systemic lupus erythematosus Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors +19 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse Cocaine addiction G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +3 more

Neutrophil extracellular trap formation Alcoholism Shigellosis Transcriptional misregulation in cancer Systemic lupus erythematosus Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Estrogen-dependent gene expression Amyloid fiber formation Factors involved in megakaryocyte development and platelet production +18 more

Neutrophil extracellular trap formation Alcoholism Shigellosis Transcriptional misregulation in cancer Systemic lupus erythematosus Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Estrogen-dependent gene expression Amyloid fiber formation Factors involved in megakaryocyte development and platelet production +18 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Focal adhesion Malaria Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Melanoma Non-small cell lung cancer Hepatocellular carcinoma Gastric cancer Platelet degranulation PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 +29 more

HIF-1 signaling pathway Mitophagy - animal Autophagy - animal Efferocytosis Th17 cell differentiation Thyroid hormone signaling pathway Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Neddylation +19 more

Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling E3 ubiquitin ligases ubiquitinate target proteins Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +25 more

Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Maturity onset diabetes of the young

Motor proteins

Transcriptional misregulation in cancer

Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids Peroxisome Central carbon metabolism in cancer Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle) +7 more

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Antifolate resistance MAPK signaling pathway Ras signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway FoxO signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Apoptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway TNF signaling pathway Neurotrophin signaling pathway Insulin signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Alcoholic liver disease Alzheimer disease Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Chagas disease Toxoplasmosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Pancreatic cancer Prostate cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation +79 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Intestinal immune network for IgA production Type I diabetes mellitus Yersinia infection Chagas disease Measles Human T-cell leukemia virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Autoimmune thyroid disease Inflammatory bowel disease Allograft rejection Graft-versus-host disease RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling +21 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation Inflammatory bowel disease Interleukin-21 signaling +2 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway Th17 cell differentiation Kaposi sarcoma-associated herpesvirus infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling +12 more

Cytokine-cytokine receptor interaction FoxO signaling pathway PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Pathways in cancer Primary immunodeficiency Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +7 more

Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling +1 more

cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling Autophagy - animal AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Insulin signaling pathway Adipocytokine signaling pathway Regulation of lipolysis in adipocytes Type II diabetes mellitus Growth hormone synthesis, secretion and action Alzheimer disease IRS-related events triggered by IGF1R +11 more

Hormone signaling Phagosome Efferocytosis PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cell adhesion molecules Regulation of actin cytoskeleton Cytoskeleton in muscle cells Thyroid hormone signaling pathway Human cytomegalovirus infection Human papillomavirus infection Pathways in cancer Proteoglycans in cancer Small cell lung cancer Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Fluid shear stress and atherosclerosis Cross-presentation of particulate exogenous antigens (phagosomes) Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans VEGFA-VEGFR2 Pathway Signal transduction by L1 Neutrophil degranulation +26 more

EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis Osteoclast differentiation Signaling pathways regulating pluripotency of stem cells Toll-like receptor signaling pathway NOD-like receptor signaling pathway JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Leishmaniasis Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Pancreatic cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation ISG15 antiviral mechanism Interleukin-7 signaling Other interleukin signaling RAF/MAP kinase cascade Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interferon gamma signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-2 signaling Interleukin-12 signaling Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA signaling +48 more

EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling Efferocytosis PI3K-Akt signaling pathway Necroptosis Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Cholinergic synapse Prolactin signaling pathway Adipocytokine signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Leishmaniasis Toxoplasmosis Tuberculosis Hepatitis B Influenza A Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Prolactin receptor signaling Signaling by SCF-KIT RMTs methylate histone arginines Interleukin-3, Interleukin-5 and GM-CSF signaling RAF activation RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cyclin D associated events in G1 Interferon gamma signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-23 signaling Interleukin-27 signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS Interleukin receptor SHC signaling Signaling downstream of RAS mutants Growth hormone receptor signaling Factors involved in megakaryocyte development and platelet production +51 more

Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Hepatitis B Measles Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Non-small cell lung cancer Primary immunodeficiency Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling +21 more

Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation