Gastresophageal junction adenocarcinoma

Polycomb repressive complex MAPK signaling pathway Pathways in cancer Transcriptional misregulation in cancer Small cell lung cancer Transcription of E2F targets under negative control by DREAM complex Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 +6 more

Endocrine resistance Platinum drug resistance FoxO signaling pathway Cell cycle p53 signaling pathway Ubiquitin mediated proteolysis Endocytosis PI3K-Akt signaling pathway Cellular senescence C-type lectin receptor signaling pathway Thyroid hormone signaling pathway Shigellosis Human cytomegalovirus infection Human papillomavirus infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity +35 more

p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 +6 more

Lysine degradation Metabolic pathways MAPK signaling pathway Pathways in cancer Chronic myeloid leukemia PKMTs methylate histone lysines Regulation of PTEN gene transcription +4 more

Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation +1 more

Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation +5 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Axon guidance Focal adhesion Adherens junction Bacterial invasion of epithelial cells Epithelial cell signaling in Helicobacter pylori infection Malaria Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Melanoma Non-small cell lung cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D mediated inhibition of cell attachment and migration RAF/MAP kinase cascade MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling InlB-mediated entry of Listeria monocytogenes into host cell MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 MECP2 regulates neuronal receptors and channels +37 more

Mitophagy - animal Osteoclast differentiation Melanogenesis Pathways in cancer Transcriptional misregulation in cancer Melanoma SUMOylation of transcription factors +4 more

Transcriptional misregulation in cancer

Platinum drug resistance Mismatch repair Fanconi anemia pathway Pathways in cancer Colorectal cancer Endometrial cancer Gastric cancer Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes +8 more

Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation +2 more

Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation +2 more

SUMOylation of transcription cofactors RHO GTPases Activate Formins

Platinum drug resistance Mismatch repair Pathways in cancer Colorectal cancer Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes +7 more

Platinum drug resistance Mismatch repair Pathways in cancer Colorectal cancer Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 +4 more

mRNA surveillance pathway

Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton Measles Proteoglycans in cancer Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +4 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway Phospholipase D signaling pathway Autophagy - other Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Apelin signaling pathway Neutrophil extracellular trap formation JAK-STAT signaling pathway Th17 cell differentiation Thermogenesis Insulin signaling pathway Thyroid hormone signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Insulin resistance Growth hormone synthesis, secretion and action Alzheimer disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Shigellosis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Pancreatic cancer Glioma Prostate cancer Acute myeloid leukemia Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Diabetic cardiomyopathy PIP3 activates AKT signaling Macroautophagy mTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1 +61 more

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family Interleukin-4 and Interleukin-13 signaling O-linked glycosylation of mucins Termination of O-glycan biosynthesis +4 more

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis +3 more

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis +3 more

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis +3 more

Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1 Defective MUTYH substrate binding +2 more

PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression

MAPK signaling pathway ErbB signaling pathway Cell cycle PI3K-Akt signaling pathway Cellular senescence Wnt signaling pathway TGF-beta signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway Thyroid hormone signaling pathway Salmonella infection Hepatitis C Hepatitis B Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Endometrial cancer Thyroid cancer Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Transcription of E2F targets under negative control by DREAM complex NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Binding of TCF/LEF:CTNNB1 to target gene promoters MAPK6/MAPK4 signaling Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry TFAP2 (AP-2) family regulates transcription of cell cycle factors RUNX3 regulates WNT signaling Estrogen-dependent gene expression +45 more

Transcriptional misregulation in cancer

Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction Regulation of actin cytoskeleton Motor proteins Cytoskeleton in muscle cells Pathogenic Escherichia coli infection Smooth Muscle Contraction RHO GTPases activate PAKs +6 more

Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction Regulation of actin cytoskeleton Motor proteins Cytoskeleton in muscle cells Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis +8 more

Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation FCGR3A-mediated phagocytosis +1 more

Parathyroid hormone synthesis, secretion and action

Homologous recombination Cellular senescence DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +13 more

Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis

Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer Breast cancer RORA activates gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis +18 more

Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Estrogen-dependent gene expression +14 more

Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway Transcriptional misregulation in cancer Nuclear signaling by ERBB4 PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis +16 more

Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis +11 more

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Regulation of RAS by GAPs RAS signaling downstream of NF1 loss-of-function variants +2 more

Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs +2 more

Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis Cellular senescence Wnt signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Oxytocin signaling pathway Yersinia infection Hepatitis B Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) +24 more

Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Lipid and atherosclerosis Fluid shear stress and atherosclerosis +4 more

MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Legionellosis Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Breast cancer RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection +19 more

Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Neurotrophin signaling pathway Adipocytokine signaling pathway Epstein-Barr virus infection PD-L1 expression and PD-1 checkpoint pathway in cancer Activation of NF-kappaB in B cells +6 more