Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
gastroesophageal junction adenocarcinoma	MONDO_0003219	ITGAV	Unknown	23525077 29703791	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		ITK	Unknown	23525077 29703791	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		JAK1	Unknown	28481359 24308032	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	23525077 29703791 24308032 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	23525077 29703791 25656989 24308032	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		JAZF1	Unknown	29703791	Open Targets	—
		JUN	Unknown	29703791	Open Targets	Endocrine resistance MAPK signaling pathway ErbB signaling pathway +63 more
		KAT6A	Unknown	23525077 29703791	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT6B	Unknown	23525077 29703791 24308032	Open Targets	HATs acetylate histones
		KCNJ5	Unknown	24308032	Open Targets	Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse +8 more
		KDM5A	Unknown	29703791 24308032	Open Targets	HDMs demethylate histones
		KDM5C	Unknown	28481359	Open Targets	HDMs demethylate histones
		KDM6A	Unknown	24308032	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	28481359 24308032	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KDSR	Unknown	24308032	Open Targets	Sphingolipid metabolism Metabolic pathways Sphingolipid de novo biosynthesis
		KEAP1	Unknown	23525077 29703791 28481359	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIF5B	Unknown	29703791	Open Targets	Endocytosis Dopaminergic synapse Motor proteins +12 more
		KIT	Unknown	29703791 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KLF4	Unknown	29703791 28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KLK2	Unknown	23525077	Open Targets	Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption Activation of Matrix Metalloproteinases +2 more
		KMT2A	Unknown	23525077 29703791 24308032	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	23525077 29703791 24308032 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	23525077 29703791 28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	29703791 24308032	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KRAS	Unknown	24308032 23525077 25656989 28859360 27566247 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	23525077 29703791	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	23525077 29703791	Open Targets	—
		LATS1	Unknown	23525077	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	29703791 28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCK	Unknown	29703791	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Natural killer cell mediated cytotoxicity +27 more
		LCP1	Unknown	23525077	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LEF1	Unknown	24308032	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		LEPROTL1	Unknown	29703791	Open Targets	—
		LHFPL6	Unknown	23525077	Open Targets	—
		LIFR	Unknown	29703791	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more
		LMO1	Unknown	29703791	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		LOC100506403	Unknown	23525077 24308032	Open Targets	—
		LOC124905021	Unknown	23525077 24308032 28481359	Open Targets	—
		LRIG3	Unknown	23525077 24308032	Open Targets	—
		LRP1B	Unknown	23525077 29703791 24308032	Open Targets	—
		LSM14A	Unknown	24308032	Open Targets	—
		LYN	Unknown	24308032	Open Targets	Chemokine signaling pathway NF-kappa B signaling pathway Platelet activation +36 more
		LZTR1	Unknown	29703791	Open Targets	—
		MAF	Unknown	29703791 24308032	Open Targets	Th1 and Th2 cell differentiation Transcriptional misregulation in cancer Inflammatory bowel disease
		MAFB	Unknown	29703791	Open Targets	Parathyroid hormone synthesis, secretion and action
		MALT1	Unknown	29703791 28481359	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		MAML2	Unknown	29703791	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP2K4	Unknown	28481359 24308032	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	23525077 29703791 24308032 28481359	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	28481359 29703791 24308032	Open Targets	MAPK signaling pathway

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Gastresophageal junction adenocarcinoma

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