Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
gastroesophageal junction adenocarcinoma	MONDO_0003219	ELF4	Unknown	24308032	Open Targets	—
		ELK4	Unknown	29703791	Open Targets	MAPK signaling pathway Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer
		ELN	Unknown	23525077	Open Targets	Cytoskeleton in muscle cells Protein digestion and absorption Degradation of the extracellular matrix +2 more
		EML4	Unknown	24308032	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		EP300	Unknown	23525077 29703791 24308032 28481359	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPAS1	Unknown	29703791	Open Targets	HIF-1 signaling pathway Pathways in cancer Renal cell carcinoma +6 more
		EPHA3	Unknown	23525077 24308032 28481359	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPHA7	Unknown	28481359 24308032	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPS15	Unknown	24308032	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		ERBB2	Unknown	23525077 25656989 29420467 24308032 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	29703791 24308032 23525077 37107676 29420467 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERBB4	Unknown	23525077 22484628 25656989 24308032 28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERC1	Unknown	29703791	Open Targets	NF-kappa B signaling pathway
		ERCC2	Unknown	29703791 28481359	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC3	Unknown	28481359	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC4	Unknown	23525077 28481359	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		ERCC5	Unknown	23525077 29703791	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		ERG	Unknown	23525077 29703791	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ESR1	Unknown	28481359	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		ETNK1	Unknown	29703791	Open Targets	Glycerophospholipid metabolism Metabolic pathways Synthesis of PE
		ETV1	Unknown	23525077 29703791	Open Targets	Transcriptional misregulation in cancer
		ETV4	Unknown	23525077	Open Targets	Transcriptional misregulation in cancer MAPK6/MAPK4 signaling
		ETV5	Unknown	23525077 29703791 24308032	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ETV6	Unknown	29703791	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EXT2	Unknown	29703791 24308032	Open Targets	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis +2 more
		EZH2	Unknown	23525077 28481359	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		EZR	Unknown	24308032	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +6 more
		FADD	Unknown	24308032	Open Targets	Platinum drug resistance Apoptosis Apoptosis - multiple species +36 more
		FAM135B	Unknown	23525077 29703791 24308032	Open Targets	—
		FAM47C	Unknown	23525077 29703791	Open Targets	—
		FANCA	Unknown	23525077 29703791 28481359	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FANCD2	Unknown	24308032	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FAT1	Unknown	23525077 29703791 24308032 28481359	Open Targets	—
		FAT3	Unknown	23525077 29703791	Open Targets	—
		FAT4	Unknown	23525077 29703791 24308032 28859360	Open Targets	Hippo signaling pathway - multiple species
		FBXO11	Unknown	23525077 28481359 29703791 24308032	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	29703791 24308032 28481359	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FCGR2B	Unknown	24308032	Open Targets	Virion - Ebolavirus, Lyssavirus and Morbillivirus Phagosome Osteoclast differentiation +6 more
		FCRL4	Unknown	23525077	Open Targets	—
		FEN1	Unknown	29703791	Open Targets	DNA replication Base excision repair Non-homologous end-joining +6 more
		FEV	Unknown	24308032	Open Targets	Transcriptional misregulation in cancer
		FGFR1	Unknown	29703791 24308032	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR2	Unknown	29703791	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FGFR3	Unknown	29703791	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FGFR4	Unknown	24308032	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		FH	Unknown	28481359 24308032	Open Targets	Citrate cycle (TCA cycle) Pyruvate metabolism Metabolic pathways +5 more
		FIP1L1	Unknown	29703791 24308032	Open Targets	mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway +4 more
		FKBP9	Unknown	23525077	Open Targets	—
		FLCN	Unknown	24308032	Open Targets	mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1
		FLI1	Unknown	23525077	Open Targets	Transcriptional misregulation in cancer

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Gastresophageal junction adenocarcinoma

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