Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
gastroesophageal junction adenocarcinoma	MONDO_0003219	PPM1D	Unknown	29703791	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PPP2R1A	Unknown	28481359	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	29703791 24308032	Open Targets	COPII-mediated vesicle transport
		PRCC	Unknown	29703791	Open Targets	Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway
		PRDM1	Unknown	28481359	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	29703791	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRDM2	Unknown	23525077 29703791	Open Targets	Lysine degradation Metabolic pathways
		PREX2	Unknown	23525077 24308032	Open Targets	Regulation of PTEN stability and activity
		PRF1	Unknown	23525077	Open Targets	Apoptosis Natural killer cell mediated cytotoxicity Type I diabetes mellitus +4 more
		PRKACA	Unknown	23525077 29703791	Open Targets	Endocrine resistance MAPK signaling pathway Ras signaling pathway +95 more
		PRKAR1A	Unknown	29703791	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PRKCB	Unknown	23525077	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRKD1	Unknown	23525077	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PSIP1	Unknown	23525077	Open Targets	Viral life cycle - HIV-1 Integration of provirus 2-LTR circle formation +4 more
		PTCH1	Unknown	23525077 29703791 28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	29703791 24308032 23525077 25656989 23930209 28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTK6	Unknown	23525077	Open Targets	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling +8 more
		PTPN11	Unknown	23525077	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPN13	Unknown	23525077 29703791	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPN6	Unknown	29703791	Open Targets	Efferocytosis Adherens junction JAK-STAT signaling pathway +22 more
		PTPRB	Unknown	23525077 29703791 24308032	Open Targets	Adherens junction Neutrophil degranulation
		PTPRC	Unknown	23525077 24308032	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis +5 more
		PTPRD	Unknown	23525077 29703791 24308032 28859360 28481359	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	23525077 29703791 24308032	Open Targets	EGFR downregulation
		PTPRT	Unknown	23525077 24308032 28481359	Open Targets	—
		PWWP2A	Unknown	29703791	Open Targets	—
		QKI	Unknown	23525077	Open Targets	Signaling by BRAF and RAF fusions
		RABEP1	Unknown	23525077	Open Targets	Endocytosis TBC/RABGAPs
		RAD17	Unknown	29703791 24308032	Open Targets	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends +3 more
		RAD21	Unknown	28481359	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		RAD50	Unknown	23525077 29703791 24308032 28481359	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51	Unknown	29703791	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +8 more
		RALGDS	Unknown	23525077	Open Targets	Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway +5 more
		RANBP2	Unknown	23525077 29703791 24308032	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RAP1GDS1	Unknown	24308032	Open Targets	—
		RARA	Unknown	29703791	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RASA1	Unknown	23525077	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RB1	Unknown	23525077 29703791 25656989 24308032	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	29703791 28481359	Open Targets	—
		RBM15	Unknown	29703791 24308032	Open Targets	—
		RECQL4	Unknown	23525077	Open Targets	—
		REL	Unknown	28481359	Open Targets	Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis +1 more
		RET	Unknown	23525077 28481359	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RGPD3	Unknown	29703791	Open Targets	—
		RGS7	Unknown	24308032	Open Targets	G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
		RHOA	Unknown	23525077 29703791 28481359	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RICTOR	Unknown	29703791 28481359	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RMI2	Unknown	29703791	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		RNF213	Unknown	24308032	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		RNF43	Unknown	23525077 24308032 28481359	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation

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Gastresophageal junction adenocarcinoma

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