Subtype of: Digestive system disease

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
digestive system melanoma	MONDO_0045070	KDSR	Unknown	28296713	Open Targets	Sphingolipid metabolism Metabolic pathways Sphingolipid de novo biosynthesis
		KIAA1549	Unknown	28296713	Open Targets	Signaling by BRAF and RAF fusions
		KIF5B	Unknown	28296713	Open Targets	Endocytosis Dopaminergic synapse Motor proteins +12 more
		KIT	Unknown	19018266 19718013 21069551 21680547 21971089 22513068 27498141 28296713 31320640 32321774	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2C	Unknown	28296713	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KNL1	Unknown	28296713	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KTN1	Unknown	28296713	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		LARP4B	Unknown	28296713	Open Targets	—
		LATS1	Unknown	28296713	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	28296713	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LEF1	Unknown	28296713	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		LIFR	Unknown	28296713	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more
		LOC105376156	Unknown	28296713	Open Targets	—
		LRP1B	Unknown	28296713	Open Targets	—
		LSM14A	Unknown	28296713	Open Targets	—
		LYN	Unknown	28296713	Open Targets	Chemokine signaling pathway NF-kappa B signaling pathway Platelet activation +36 more
		MAML2	Unknown	28296713	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP3K1	Unknown	28296713 32321774	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	28296713	Open Targets	MAPK signaling pathway
		MAX	Unknown	28296713 32321774	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MDM2	Unknown	31320640	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		MED12	Unknown	28296713 32321774	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MET	Unknown	28296713 29264386 32321774	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MLF1	Unknown	28296713	Open Targets	Transcriptional misregulation in cancer
		MLH1	Unknown	28296713 32321774	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT1	Unknown	28296713	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MLLT10	Unknown	28296713	Open Targets	—
		MN1	Unknown	31320640 28296713	Open Targets	—
		MNX1	Unknown	28296713	Open Targets	Maturity onset diabetes of the young
		MPL	Unknown	28296713 32321774	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MSH2	Unknown	31320640 32321774	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSI2	Unknown	28296713	Open Targets	mRNA surveillance pathway
		MSN	Unknown	28296713	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +4 more
		MTCP1	Unknown	28296713	Open Targets	PI3K-Akt signaling pathway
		MTOR	Unknown	28296713 32321774	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC16	Unknown	31320640 28296713	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	31320640 28296713	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC6	Unknown	28296713	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYCN	Unknown	28296713 32321774	Open Targets	Transcriptional misregulation in cancer
		MYH11	Unknown	28296713	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		MYH9	Unknown	28296713	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		MYO5A	Unknown	28296713	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		NBEA	Unknown	28296713	Open Targets	—
		NCKIPSD	Unknown	28296713	Open Targets	Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis
		NCOA1	Unknown	28296713	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer +18 more
		NCOR1	Unknown	28296713	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NCOR2	Unknown	28296713	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NFATC2	Unknown	31320640	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis +24 more
		NFE2L2	Unknown	29264386 32321774	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFKB2	Unknown	28296713	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more

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Digestive system melanoma

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