Digestive system melanoma

Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes

Fanconi anemia pathway Fanconi Anemia Pathway

Hippo signaling pathway - multiple species

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Adherens junction Signaling pathways regulating pluripotency of stem cells Thermogenesis Regulation of actin cytoskeleton Parathyroid hormone synthesis, secretion and action Pathways in cancer Proteoglycans in cancer Prostate cancer Melanoma Breast cancer Central carbon metabolism in cancer PI3K Cascade PIP3 activates AKT signaling Signaling by FGFR1 amplification mutants Signaling by activated point mutants of FGFR1 FGFR1b ligand binding and activation FGFR1c ligand binding and activation FGFR1c and Klotho ligand binding and activation Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Phospholipase C-mediated cascade: FGFR1 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling Negative regulation of FGFR1 signaling Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by plasma membrane FGFR1 fusions +32 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Endocytosis PI3K-Akt signaling pathway Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton Pathways in cancer MicroRNAs in cancer Bladder cancer Central carbon metabolism in cancer PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR3 FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR3 mutant receptor activation t(4;14) translocations of FGFR3 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR3 SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 Negative regulation of FGFR3 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer +27 more

Purine metabolism Metabolic pathways Small cell lung cancer Non-small cell lung cancer +1 more

mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1

MAPK signaling pathway Focal adhesion Salmonella infection Proteoglycans in cancer Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response +6 more

MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway Hematopoietic cell lineage Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Central carbon metabolism in cancer PI3K Cascade RAF/MAP kinase cascade FLT3 Signaling +8 more

EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway FoxO signaling pathway Mitophagy - animal PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Neurotrophin signaling pathway Prolactin signaling pathway Alcoholic liver disease Shigellosis Chemical carcinogenesis - reactive oxygen species Endometrial cancer Non-small cell lung cancer Signaling by NODAL AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling +26 more

Ras signaling pathway FoxO signaling pathway Shigellosis AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes +7 more

mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Transcriptional misregulation in cancer mRNA Splicing - Major Pathway +3 more

RHO GTPases regulate CFTR trafficking

Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport +9 more

A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Release of Hh-Np from the secreting cell Retinoid metabolism and transport +7 more

Folate biosynthesis Metabolic pathways Biosynthesis of cofactors GABAergic synapse Molybdenum cofactor biosynthesis +2 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse Cocaine addiction G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +3 more

Basal transcription factors cGMP-PKG signaling pathway

Neutrophil extracellular trap formation Alcoholism Shigellosis Transcriptional misregulation in cancer Systemic lupus erythematosus Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Estrogen-dependent gene expression Amyloid fiber formation Factors involved in megakaryocyte development and platelet production +18 more

HIF-1 signaling pathway Mitophagy - animal Autophagy - animal Efferocytosis Th17 cell differentiation Thyroid hormone signaling pathway Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Neddylation +19 more

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling E3 ubiquitin ligases ubiquitinate target proteins Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +25 more

Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF) +4 more

Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Transcriptional misregulation in cancer

Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis Antigen processing and presentation NOD-like receptor signaling pathway IL-17 signaling pathway Th17 cell differentiation Progesterone-mediated oocyte maturation Estrogen signaling pathway Salmonella infection Pathways in cancer Chemical carcinogenesis - receptor activation Prostate cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation vRNP Assembly Regulation of actin dynamics for phagocytic cup formation eNOS activation Regulation of PLK1 Activity at G2/M Transition Scavenging by Class F Receptors HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase HSF1-dependent transactivation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Sema3A PAK dependent Axon repulsion VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability Uptake and function of diphtheria toxin Anchoring of the basal body to the plasma membrane Constitutive Signaling by EGFRvIII Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Downregulation of ERBB2 signaling ESR-mediated signaling Extra-nuclear estrogen signaling Estrogen-dependent gene expression Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants +56 more

Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids Peroxisome Central carbon metabolism in cancer Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import +9 more

Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids Peroxisome Central carbon metabolism in cancer Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle) +7 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation Inflammatory bowel disease Interleukin-21 signaling +2 more

Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling +1 more

cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling Autophagy - animal AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Insulin signaling pathway Adipocytokine signaling pathway Regulation of lipolysis in adipocytes Type II diabetes mellitus Growth hormone synthesis, secretion and action Alzheimer disease IRS-related events triggered by IGF1R +11 more

Hormone signaling Phagosome Efferocytosis PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cell adhesion molecules Regulation of actin cytoskeleton Cytoskeleton in muscle cells Thyroid hormone signaling pathway Human cytomegalovirus infection Human papillomavirus infection Pathways in cancer Proteoglycans in cancer Small cell lung cancer Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Fluid shear stress and atherosclerosis Cross-presentation of particulate exogenous antigens (phagosomes) Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans VEGFA-VEGFR2 Pathway Signal transduction by L1 Neutrophil degranulation +26 more

Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration Generation of second messenger molecules FCERI mediated Ca+2 mobilization +2 more

EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling Efferocytosis PI3K-Akt signaling pathway Necroptosis Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Cholinergic synapse Prolactin signaling pathway Adipocytokine signaling pathway AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Leishmaniasis Toxoplasmosis Tuberculosis Hepatitis B Influenza A Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Prolactin receptor signaling Signaling by SCF-KIT RMTs methylate histone arginines Interleukin-3, Interleukin-5 and GM-CSF signaling RAF activation RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cyclin D associated events in G1 Interferon gamma signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-23 signaling Interleukin-27 signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS Interleukin receptor SHC signaling Signaling downstream of RAS mutants Growth hormone receptor signaling Factors involved in megakaryocyte development and platelet production +51 more

Endocrine resistance MAPK signaling pathway ErbB signaling pathway cAMP signaling pathway Mitophagy - animal Apoptosis Wnt signaling pathway Osteoclast differentiation Focal adhesion Tight junction Toll-like receptor signaling pathway NOD-like receptor signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway TNF signaling pathway Neurotrophin signaling pathway GnRH signaling pathway Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Cocaine addiction Amphetamine addiction Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Yersinia infection Leishmaniasis Chagas disease Hepatitis B Measles Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Breast cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Rheumatoid arthritis Lipid and atherosclerosis Fluid shear stress and atherosclerosis Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping +63 more

Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation

HATs acetylate histones

HATs acetylate histones

Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse Dopaminergic synapse Estrogen signaling pathway Oxytocin signaling pathway Aldosterone synthesis and secretion GnRH secretion Morphine addiction Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +8 more

HDMs demethylate histones

Transcriptional misregulation in cancer HDMs demethylate histones