Diabetic retinopathy

ABC transporters Mitochondrial ABC transporters

Renin-angiotensin system Renin secretion Chagas disease Coronavirus disease - COVID-19 Hypertrophic cardiomyopathy Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +4 more

Renin-angiotensin system Protein digestion and absorption Coronavirus disease - COVID-19 Metabolism of Angiotensinogen to Angiotensins +1 more

Thiamine metabolism Riboflavin metabolism Metabolic pathways Adherens junction Chemical carcinogenesis - reactive oxygen species +2 more

Purine metabolism Metabolic pathways Endocrine resistance Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Longevity regulating pathway Longevity regulating pathway - multiple species Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Gap junction Platelet activation Circadian entrainment Thermogenesis Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Ovarian steroidogenesis Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Salivary secretion Gastric acid secretion Pancreatic secretion Bile secretion Parkinson disease Cocaine addiction Amphetamine addiction Morphine addiction Alcoholism Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis +66 more

PPAR signaling pathway Hormone signaling AMPK signaling pathway Longevity regulating pathway Adipocytokine signaling pathway Type II diabetes mellitus Non-alcoholic fatty liver disease Alcoholic liver disease AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation +7 more

Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Thermogenesis Regulation of lipolysis in adipocytes Renin secretion Salivary secretion Chemical carcinogenesis - receptor activation Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +9 more

Endocytosis

Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications Alzheimer disease Pathways of neurodegeneration - multiple diseases Diabetic cardiomyopathy Lipid and atherosclerosis TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation +7 more

Triglyceride biosynthesis

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Renin-angiotensin system Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion Insulin resistance AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Pathways in cancer Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events +18 more

Calcium signaling pathway cGMP-PKG signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Renin-angiotensin system Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Coronavirus disease - COVID-19 Pathways in cancer Diabetic cardiomyopathy Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +18 more

Pentose and glucuronate interconversions Fructose and mannose metabolism Galactose metabolism Glycerolipid metabolism Folate biosynthesis Metabolic pathways Pregnenolone biosynthesis Fructose biosynthesis +5 more

Amyotrophic lateral sclerosis Adherens junctions interactions

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway HIF-1 signaling pathway PI3K-Akt signaling pathway Rheumatoid arthritis Tie2 Signaling RAF/MAP kinase cascade +5 more

Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions COPI-mediated anterograde transport +1 more

Lysosome

Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism Lipid and atherosclerosis Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance LDL clearance LDL remodeling VLDL clearance Retinoid metabolism and transport +20 more

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

Endocytosis Rho GTPase cycle

Rho GTPase cycle

Yersinia infection EPHB-mediated forward signaling

Inflammatory mediator regulation of TRP channels Stimuli-sensing channels

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway Thermogenesis +1 more

NOD-like receptor signaling pathway

Platinum drug resistance MAPK signaling pathway p53 signaling pathway Efferocytosis Apoptosis Apoptosis - multiple species Cytosolic DNA-sensing pathway Natural killer cell mediated cytotoxicity IL-17 signaling pathway TNF signaling pathway Serotonergic synapse Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Small cell lung cancer Viral myocarditis Lipid and atherosclerosis Activation of caspases through apoptosome-mediated cleavage Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Apoptosis induced DNA fragmentation Signaling by Hippo NADE modulates death signalling Caspase-mediated cleavage of cytoskeletal proteins Apoptotic cleavage of cell adhesion proteins Caspase activation via Dependence Receptors in the absence of ligand Other interleukin signaling +53 more

Endocrine resistance FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Cellular senescence Wnt signaling pathway Hedgehog signaling pathway Apelin signaling pathway Hippo signaling pathway Focal adhesion Tight junction JAK-STAT signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Alcoholic liver disease Hepatitis C Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Viral myocarditis SCF(Skp2)-mediated degradation of p27/p21 RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling +58 more

FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Wnt signaling pathway Hedgehog signaling pathway Hippo signaling pathway Focal adhesion JAK-STAT signaling pathway Prolactin signaling pathway Measles Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity +18 more

tRNA modification in the nucleus and cytosol

Deposition of new CENPA-containing nucleosomes at the centromere

Complement and coagulation cascades Staphylococcus aureus infection Coronavirus disease - COVID-19 Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade +3 more

Complement and coagulation cascades Staphylococcus aureus infection Regulation of Complement cascade

Complement and coagulation cascades Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade +2 more

cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Adrenergic signaling in cardiomyocytes TNF signaling pathway Thermogenesis Cholinergic synapse Dopaminergic synapse Insulin secretion Estrogen signaling pathway Thyroid hormone synthesis Glucagon signaling pathway Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Insulin resistance Cushing syndrome Growth hormone synthesis, secretion and action Vasopressin-regulated water reabsorption Huntington disease Prion disease Cocaine addiction Amphetamine addiction Alcoholism Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Chemical carcinogenesis - receptor activation Prostate cancer +31 more

Classical antibody-mediated complement activation

Regulation of HSF1-mediated heat shock response

cAMP signaling pathway HIF-1 signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction TNF signaling pathway Melanogenesis Renin secretion Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Hypertrophic cardiomyopathy Fluid shear stress and atherosclerosis Peptide ligand-binding receptors G alpha (q) signalling events +11 more

Cytoskeleton in muscle cells Protein digestion and absorption Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres +2 more

Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling Efferocytosis PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Pathways in cancer Regulation of gene expression by Hypoxia-inducible Factor Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS +8 more

Insulin processing VxPx cargo-targeting to cilium

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Melanoma Breast cancer Gastric cancer PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Syndecan interactions Non-integrin membrane-ECM interactions Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer +56 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway HIF-1 signaling pathway PI3K-Akt signaling pathway Focal adhesion Transcriptional misregulation in cancer Rheumatoid arthritis Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization +8 more

Reversal of alkylation damage by DNA dioxygenases