Diabetic retinopathy

Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Calcium signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Apelin signaling pathway Platelet activation Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Insulin resistance AGE-RAGE signaling pathway in diabetic complications Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling +24 more

AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Detoxification of Reactive Oxygen Species +3 more

Cell adhesion molecules Neurexins and neuroligins

MAPK signaling pathway Ras signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Neurotrophin signaling pathway Alcoholism Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through FRS2 and FRS3 NTRK2 activates RAC1 +6 more

Olfactory transduction Olfactory Signaling Pathway

Olfactory transduction Olfactory Signaling Pathway

Maturity onset diabetes of the young

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway Phospholipase D signaling pathway Hormone signaling Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Apoptosis Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Axon guidance VEGF signaling pathway Osteoclast differentiation Focal adhesion Signaling pathways regulating pluripotency of stem cells Platelet activation Neutrophil extracellular trap formation Toll-like receptor signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis TNF signaling pathway Leukocyte transendothelial migration Neurotrophin signaling pathway Cholinergic synapse Inflammatory mediator regulation of TRP channels Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Regulation of lipolysis in adipocytes Relaxin signaling pathway GnRH secretion Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Carbohydrate digestion and absorption Alzheimer disease Spinocerebellar ataxia Prion disease Bacterial invasion of epithelial cells Shigellosis Yersinia infection Chagas disease Amoebiasis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events GP1b-IX-V activation signalling VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling Extra-nuclear estrogen signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +150 more

Glycerolipid metabolism Metabolic pathways Acyl chain remodeling of DAG and TAG

Synthesis of 5-eicosatetraenoic acids

Ribosome biogenesis in eukaryotes tRNA processing in the nucleus

PPAR signaling pathway Efferocytosis AMPK signaling pathway Longevity regulating pathway Osteoclast differentiation Thermogenesis Non-alcoholic fatty liver disease Huntington disease Pathways in cancer Transcriptional misregulation in cancer Thyroid cancer Lipid and atherosclerosis PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of PTEN gene transcription +13 more

Neuroactive ligand-receptor interaction Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +1 more

Type I diabetes mellitus Neutrophil degranulation

HIF-1 signaling pathway p53 signaling pathway Cellular senescence Apelin signaling pathway Hippo signaling pathway Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications Chagas disease Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot +10 more

Wnt signaling pathway

Nicotinate and nicotinamide metabolism Metabolic pathways FoxO signaling pathway Efferocytosis AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Wnt signaling pathway Glucagon signaling pathway Alcoholic liver disease Amphetamine addiction MicroRNAs in cancer Regulation of HSF1-mediated heat shock response SIRT1 negatively regulates rRNA expression Regulation of FOXO transcriptional activity by acetylation +13 more

Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Insulin processing Zinc efflux and compartmentalization by the SLC30 family

Oocyte meiosis

Peroxisome Longevity regulating pathway - multiple species Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Platelet degranulation Detoxification of Reactive Oxygen Species Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +8 more

Detoxification of Reactive Oxygen Species

Telomere C-strand synthesis initiation

N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways Protein processing in endoplasmic reticulum +1 more

MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Leishmaniasis Toxoplasmosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Lipid and atherosclerosis Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation +33 more

Myogenesis

Wnt signaling pathway Hippo signaling pathway Adherens junction Melanogenesis Cushing syndrome Alcoholic liver disease Salmonella infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Acute myeloid leukemia Breast cancer Hepatocellular carcinoma Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes TCF7L2 mutants don't bind CTBP Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling +26 more

MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway Cell cycle Efferocytosis Cellular senescence TGF-beta signaling pathway Osteoclast differentiation Hippo signaling pathway Th17 cell differentiation Intestinal immune network for IgA production Relaxin signaling pathway Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Leishmaniasis Chagas disease Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Proteoglycans in cancer Colorectal cancer Renal cell carcinoma Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Inflammatory bowel disease Rheumatoid arthritis Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Platelet degranulation Influenza Virus Induced Apoptosis Cell surface interactions at the vascular wall Molecules associated with elastic fibres Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Syndecan interactions SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Interleukin-4 and Interleukin-13 signaling RUNX3 regulates CDKN1A transcription Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF +49 more

MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway Endocytosis Cellular senescence TGF-beta signaling pathway Osteoclast differentiation Hippo signaling pathway Adherens junction Th17 cell differentiation Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Chagas disease Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Transcriptional misregulation in cancer Colorectal cancer Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Diabetic cardiomyopathy Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer +28 more

tRNA modification in the nucleus and cytosol

Rap1 signaling pathway p53 signaling pathway Phagosome Efferocytosis PI3K-Akt signaling pathway TGF-beta signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Malaria Human papillomavirus infection Proteoglycans in cancer MicroRNAs in cancer Bladder cancer Platelet degranulation Signaling by PDGF Integrin cell surface interactions Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function +17 more

NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome PI3K-Akt signaling pathway Necroptosis Neutrophil extracellular trap formation Toll-like receptor signaling pathway NOD-like receptor signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis B Measles Influenza A Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Proteoglycans in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Rheumatoid arthritis Lipid and atherosclerosis ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation +41 more

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway Sphingolipid signaling pathway mTOR signaling pathway Apoptosis Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage Natural killer cell mediated cytotoxicity IL-17 signaling pathway T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Proteoglycans in cancer Asthma Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Hypertrophic cardiomyopathy Dilated cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling +72 more

Cytokine-cytokine receptor interaction TNFs bind their physiological receptors