Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CROHN DISEASE	MESH:D003424	TAGAP	Unknown	21102463 36038634	CTD	Rho GTPase cycle
		TCF7	Unknown	24994854	CTD	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		TLR4	Unknown	17914947	CTD	NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome +41 more
		TLR9	Unknown	15236225 17914947	CTD	Toll-like receptor signaling pathway Salmonella infection Chagas disease +12 more
		TNF	Unknown	10700533 21829567	CTD	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +72 more
		TNFSF15	Unknown	37156999	CTD	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
		TYK2	Unknown	21102463	CTD	Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway +28 more
		VTN	Unknown	19751734	CTD	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +8 more
CROHN'S DISEASE	EFO_0000384	ABHD17C	Unknown	37156999	GWAS catalog	—
		ABL2	Unknown	37156999	GWAS catalog	ErbB signaling pathway Ras signaling pathway Chemical carcinogenesis - reactive oxygen species +2 more
		ABLIM3	Unknown	35232999	GWAS catalog	Axon guidance
		ABO	Unknown	37156999	GWAS catalog	Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways +1 more
		ACO2	Unknown	26192919	GWAS catalog	Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism Metabolic pathways +4 more
		ACTA2	Unknown	26974007	GWAS catalog	Vascular smooth muscle contraction Apelin signaling pathway Motor proteins +3 more
		ACTR1A	Unknown	37156999	GWAS catalog	Motor proteins Amyotrophic lateral sclerosis Huntington disease +13 more
		ADAD1	Unknown	28067908 37523193	GWAS catalog	—
		ADAM30	Unknown	23128233 26192919	GWAS catalog	Interaction With Cumulus Cells And The Zona Pellucida
		ADAMTS6	Unknown	30801121	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAP1	Unknown	35512355 37156999	GWAS catalog	Nuclear signaling by ERBB4
		ADCY3	Unknown	23128233 26192919 26974007 28067908	GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		ADCY7	Unknown	26301688 28067908	GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +58 more
		ADGRL2	Unknown	26301688	GWAS catalog	—
		ADO	Unknown	26192919	GWAS catalog	Taurine and hypotaurine metabolism Metabolic pathways Degradation of cysteine and homocysteine
		AFAP1L1	Unknown	35232999	GWAS catalog	—
		AHR	Unknown	26974007	GWAS catalog	Th17 cell differentiation Cushing syndrome Chemical carcinogenesis - receptor activation +6 more
		AKAP11	Unknown	26192919	GWAS catalog	—
		ALAS1	Unknown	38154582	GWAS catalog	Glycine, serine and threonine metabolism Porphyrin metabolism Metabolic pathways +4 more
		ALDH5A1	Unknown	30801121	GWAS catalog	Alanine, aspartate and glutamate metabolism Butanoate metabolism Metabolic pathways +1 more
		ALG11	Unknown	37156999	GWAS catalog	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways +1 more
		ALOX5AP	Unknown	38154582	GWAS catalog	Fc epsilon RI signaling pathway Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) +1 more
		AMZ1	Unknown	28067908	GWAS catalog	—
		ANK2	Unknown	35232999	GWAS catalog	Cytoskeleton in muscle cells Proteoglycans in cancer Interaction between L1 and Ankyrins +1 more
		ANKRD10	Unknown	30801121	GWAS catalog	—
		ANKRD23	Unknown	38154582	GWAS catalog	Cytoskeleton in muscle cells
		ANKRD55	Unknown	23128233 26192919 26301688 26974007 28067908 37156999	GWAS catalog	—
		ANTXR2	Unknown	26974007	GWAS catalog	NOD-like receptor signaling pathway Uptake and function of anthrax toxins
		APEH	Unknown	37156999	GWAS catalog	Neutrophil degranulation Eukaryotic Translation Termination
		AQP12B	Unknown	26974007 28067908	GWAS catalog	—
		ARAP2	Unknown	37156999	GWAS catalog	Endocytosis Rho GTPase cycle
		ARHGAP26	Unknown	37156999	GWAS catalog	Rho GTPase cycle
		ARPC2	Unknown	26192919	GWAS catalog	Endocytosis Tight junction Fc gamma R-mediated phagocytosis +11 more
		ASAP2	Unknown	26974007	GWAS catalog	Endocytosis Fc gamma R-mediated phagocytosis
		ASCL2	Unknown	26974007	GWAS catalog	—
		ATG5	Unknown	26974007 37262302	GWAS catalog	Autophagy - other Autophagy - animal Longevity regulating pathway +8 more
		ATP2A2	Unknown	37156999	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +16 more
		ATP6V1G3	Unknown	26192919 28067908	GWAS catalog	Oxidative phosphorylation Metabolic pathways Phagosome +12 more
		ATXN2	Unknown	26192919 26974007 28067908	GWAS catalog	Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		ATXN2L	Unknown	26301688	GWAS catalog	Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		BANK1	Unknown	23128233 26192919 26974007 28067908	GWAS catalog	B cell receptor signaling pathway
		BIN1	Unknown	37156999	GWAS catalog	Endocytosis Fc gamma R-mediated phagocytosis Clathrin-mediated endocytosis
		TAGAP	Unknown	21102463 21298027 23128233 26192919 26974007 28067908 33686288 37156999	GWAS catalog	Rho GTPase cycle
		TLR4	Unknown	26974007 37156999	GWAS catalog	NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome +41 more
		TNF	Unknown	21102463 37262302	GWAS catalog	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +72 more
		TNFSF15	Unknown	18587394 18758464 21102463 21699788 23128233 23266558 26192919 26301688 26891255 26974007 30500874 32581322 35512355 37156999 37523193	GWAS catalog	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
		TYK2	Unknown	21102463 26192919 26974007 33608531 37156999	GWAS catalog	Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway +28 more
CROHNS DISEASE OF LARGE BOWEL	C0156147	TAGAP	Unknown	—	Disgenet	Rho GTPase cycle
		TCF7	Unknown	—	Disgenet	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		TLR4	Unknown	—	Disgenet	NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome +41 more
		TLR9	Unknown	—	Disgenet	Toll-like receptor signaling pathway Salmonella infection Chagas disease +12 more
		TNF	Unknown	—	Disgenet	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +72 more
		TNFSF15	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
		TYK2	Unknown	—	Disgenet	Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway +28 more
		VTN	Unknown	—	Disgenet	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +8 more

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Crohn disease

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