Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
COLORECTAL NEOPLASMS	MESH:D015179	PPM1E	Unknown	21278247	CTD	—
		PPOX	Unknown	25944804	CTD	Porphyrin metabolism Metabolic pathways Biosynthesis of cofactors +1 more
		PPP1R14A	Unknown	17892325	CTD	Vascular smooth muscle contraction RHO GTPases activate PKNs
		PRKCB	Unknown	7705931	CTD	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRKCE	Unknown	7705931	CTD	cGMP-PKG signaling pathway Sphingolipid signaling pathway Vascular smooth muscle contraction +14 more
		PRKD1	Unknown	21278247	CTD	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PROM1	Unknown	18829568	CTD	Transcriptional misregulation in cancer
		PTGS2	Unknown	10485483 11375891 12837940 15753380 19671906 20427397	CTD	Arachidonic acid metabolism Metabolic pathways NF-kappa B signaling pathway +29 more
		PTPN12	Unknown	—	CTD	SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF +3 more
		PTPRD	Unknown	18507500 21278247	CTD	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRJ	Unknown	—	CTD	Adherens junction Chemical carcinogenesis - reactive oxygen species Phosphorylation of CD3 and TCR zeta chains +2 more
		PYCARD	Unknown	17986858	CTD	Necroptosis NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway +13 more
		RAD54B	Unknown	—	CTD	Homologous recombination
		RASL11A	Unknown	30224643	CTD	—
		RBM38	Unknown	34453780	CTD	—
		RET	Unknown	18507500 21278247	CTD	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RHPN2	Unknown	19011631	CTD	RHO GTPases Activate Rhotekin and Rhophilins
		RNF182	Unknown	18507500	CTD	Antigen processing: Ubiquitination & Proteasome degradation
		RNF43	Unknown	25344691	CTD	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		RRM2	Unknown	15814641	CTD	Purine metabolism Pyrimidine metabolism Glutathione metabolism +7 more
		SATB2	Unknown	30510241	CTD	SUMOylation of chromatin organization proteins
		SCG5	Unknown	18084292	CTD	—
		SELENBP1	Unknown	18435490	CTD	Sulfur metabolism Metabolic pathways
		SELENOP	Unknown	18483336	CTD	Platelet degranulation
		SERPINB5	Unknown	16331619	CTD	p53 signaling pathway MicroRNAs in cancer
		SESN2	Unknown	31054940	CTD	p53 signaling pathway mTOR signaling pathway Longevity regulating pathway +2 more
		SFRP1	Unknown	17923031 18716850	CTD	Wnt signaling pathway
		SFRP2	Unknown	17923031 18716850	CTD	Wnt signaling pathway
		SFRP4	Unknown	17923031	CTD	Wnt signaling pathway
		SFRP5	Unknown	17923031	CTD	Wnt signaling pathway
		SFXN1	Unknown	25944804	CTD	—
		SH3TC1	Unknown	21278247	CTD	—
		SLC19A1	Unknown	16963246	CTD	Antifolate resistance Vitamin digestion and absorption Folate transport and metabolism +1 more
		SLC22A15	Unknown	21278247	CTD	Organic cation transport
		SLCO1B3	Unknown	29491222	CTD	Bile secretion Folate transport and metabolism Recycling of bile acids and salts +3 more
		SLCO2A1	Unknown	30510241	CTD	Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) Transport of organic anions
		SMAD3	Unknown	30510241	CTD	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	16144935 20565773 25944804	CTD	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMAD7	Unknown	17934461	CTD	TGF-beta signaling pathway Hippo signaling pathway Signaling by BMP +3 more
		SMAD9	Unknown	30510241	CTD	Hormone signaling TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +1 more
		SOD2	Unknown	10853026 12907644	CTD	FoxO signaling pathway Peroxisome Longevity regulating pathway +9 more
		SOX17	Unknown	18413743	CTD	Wnt signaling pathway Deactivation of the beta-catenin transactivating complex
		SP1	Unknown	35072892	CTD	Endocrine resistance Mitophagy - animal TGF-beta signaling pathway +18 more
		SPARC	Unknown	18458674	CTD	Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans +1 more
		SRC	Unknown	—	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more
		STARD8	Unknown	18507500 21278247	CTD	Rho GTPase cycle
		STIP1	Unknown	33766539	CTD	Prion disease HSP90 chaperone cycle for steroid hormone receptors (SHR)
		STRAP	Unknown	15720808	CTD	Downregulation of TGF-beta receptor signaling
		SULT2B1	Unknown	29766219	CTD	Steroid hormone biosynthesis Metabolic pathways Cytosolic sulfonation of small molecules
		SYNE1	Unknown	18507500 21278247	CTD	Cytoskeleton in muscle cells

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Colorectal neoplasms

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