Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
COLORECTAL NEOPLASMS	MESH:D015179	KDR	Unknown	20346928 35917945	CTD	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KLF2	Unknown	30510241	CTD	FoxO signaling pathway Apelin signaling pathway Fluid shear stress and atherosclerosis
		KLF5	Unknown	30510241	CTD	Chemical carcinogenesis - receptor activation
		KRAS	Unknown	20565773 21369707 25280562	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LAMA1	Unknown	21278247	CTD	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +12 more
		LGR5	Unknown	25280562	CTD	Wnt signaling pathway Regulation of FZD by ubiquitination
		LGR6	Unknown	18507500 21278247	CTD	Wnt signaling pathway Regulation of FZD by ubiquitination
		LPAR1	Unknown	30510241	CTD	Rap1 signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction +8 more
		LRRC3B	Unknown	18815942	CTD	—
		LY96	Unknown	22180778	CTD	NF-kappa B signaling pathway Toll-like receptor signaling pathway Alcoholic liver disease +17 more
		MAF	Unknown	30510241	CTD	Th1 and Th2 cell differentiation Transcriptional misregulation in cancer Inflammatory bowel disease
		MCC	Unknown	—	CTD	Wnt signaling pathway
		MKI67	Unknown	12645814	CTD	—
		MLH1	Unknown	18497967 18718023 18949393	CTD	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLH3	Unknown	17656264	CTD	Mismatch repair
		MMP1	Unknown	23548910	CTD	PPAR signaling pathway IL-17 signaling pathway Relaxin signaling pathway +11 more
		MMP2	Unknown	18507500 21278247	CTD	Endocrine resistance Leukocyte transendothelial migration GnRH signaling pathway +15 more
		MSH2	Unknown	18949393	CTD	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MTDH	Unknown	29315995	CTD	—
		MTHFR	Unknown	15608557 16512993 16985020 17047490 17087956 17245555 17350979 18676755 26858257	CTD	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		MTRR	Unknown	16985020 17389618	CTD	Cobalamin transport and metabolism Methylation Sulfur amino acid metabolism +3 more
		MYC	Unknown	30510241	CTD	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		NAMPT	Unknown	23922874 32005247	CTD	Nicotinate and nicotinamide metabolism Metabolic pathways NOD-like receptor signaling pathway +2 more
		NEURL1	Unknown	17892325	CTD	Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
		NME1	Unknown	15814641	CTD	Purine metabolism Pyrimidine metabolism Drug metabolism - other enzymes +4 more
		NME2	Unknown	15814641	CTD	Purine metabolism Pyrimidine metabolism Drug metabolism - other enzymes +5 more
		NQO1	Unknown	20593958	CTD	Ubiquinone and other terpenoid-quinone biosynthesis Metabolic pathways Biosynthesis of cofactors +5 more
		NR4A2	Unknown	16293616	CTD	Aldosterone synthesis and secretion Parathyroid hormone synthesis, secretion and action Nuclear Receptor transcription pathway
		NRAS	Unknown	—	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NRCAM	Unknown	18507500 21278247	CTD	Cell adhesion molecules Neurofascin interactions
		NT5C	Unknown	15814641	CTD	Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism +4 more
		NTNG1	Unknown	21278247	CTD	Axon guidance Cell adhesion molecules Post-translational modification: synthesis of GPI-anchored proteins
		NUSAP1	Unknown	25944804	CTD	—
		NXN	Unknown	24836286	CTD	—
		ODC1	Unknown	21930798	CTD	Arginine and proline metabolism Glutathione metabolism Metabolic pathways +3 more
		PAIP2	Unknown	25944804	CTD	—
		PARP1	Unknown	27694308	CTD	Base excision repair NF-kappa B signaling pathway Apoptosis +9 more
		PAX8	Unknown	26075790	CTD	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PDGFRL	Unknown	—	CTD	—
		PGM1	Unknown	25944804	CTD	Glycolysis / Gluconeogenesis Pentose phosphate pathway Galactose metabolism +8 more
		PHETA1	Unknown	25944804	CTD	—
		PIK3CA	Unknown	—	CTD	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PLA2G2A	Unknown	—	CTD	Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism +14 more
		PMM2	Unknown	25944804	CTD	Fructose and mannose metabolism Amino sugar and nucleotide sugar metabolism Metabolic pathways +4 more
		POLD1	Unknown	23263490	CTD	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLD3	Unknown	22634755 30510241	CTD	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	23263490 26053496	CTD	DNA replication Base excision repair Nucleotide excision repair +10 more
		PON1	Unknown	31004929	CTD	Synthesis of 5-eicosatetraenoic acids
		POSTN	Unknown	15731169	CTD	—
		PPARG	Unknown	16489531	CTD	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS	MESH:D003123	MLH1	Unknown	14756672 20020535 21064154 22102614 25701956	CTD	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLH3	Unknown	12702580	CTD	Mismatch repair
		MSH2	Unknown	12702580 14756672 22102614 25701956	CTD	Platinum drug resistance Mismatch repair Pathways in cancer +7 more

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Colorectal neoplasms

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