Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
COLORECTAL CANCER	MONDO_0005575	IDS	Unknown	25866641	GWAS catalog	Glycosaminoglycan degradation Metabolic pathways Lysosome +3 more
		IFNGR1	Unknown	38411962	GWAS catalog	Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis +17 more
		IGF2BP2	Unknown	35512400 37340002	GWAS catalog	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IGSF11	Unknown	38538606	GWAS catalog	Cell adhesion molecules
		IL15	Unknown	36077729	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway TNF signaling pathway +5 more
		IL2RA	Unknown	38538606	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis +12 more
		INPP4B	Unknown	36077729	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +3 more
		INPP5B	Unknown	38872215	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +3 more
		INSR	Unknown	35512400	GWAS catalog	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +26 more
		IPO5	Unknown	38411962	GWAS catalog	Nucleocytoplasmic transport vRNP Assembly
		IQCM	Unknown	25866641	GWAS catalog	—
		IRAG2	Unknown	38411962	GWAS catalog	Neutrophil degranulation
		IREB2	Unknown	38538606	GWAS catalog	Iron uptake and transport
		IRF4	Unknown	33893285 34290314	GWAS catalog	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		ISM1	Unknown	25866641	GWAS catalog	—
		IZUMO1R	Unknown	38538606	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		JAKMIP2	Unknown	38411962	GWAS catalog	—
		JAZF1	Unknown	32887889	GWAS catalog	—
		JRK	Unknown	34290314 37340002	GWAS catalog	—
		KANSL1	Unknown	32887889	GWAS catalog	HATs acetylate histones
		KAZN	Unknown	29228715 36077729	GWAS catalog	Formation of the cornified envelope
		KCNB2	Unknown	37890997	GWAS catalog	Voltage gated Potassium channels
		KCNH1	Unknown	27197191	GWAS catalog	Voltage gated Potassium channels
		KCNIP4	Unknown	29228715	GWAS catalog	Phase 1 - inactivation of fast Na+ channels
		KCNK1	Unknown	38411962	GWAS catalog	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential
		KCNK9	Unknown	38411962	GWAS catalog	Aldosterone synthesis and secretion TWIK-releated acid-sensitive K+ channel (TASK) Phase 4 - resting membrane potential
		KCNQ1	Unknown	37340002	GWAS catalog	Adrenergic signaling in cardiomyocytes Cholinergic synapse Gastric acid secretion +6 more
		KCNQ4	Unknown	36077729	GWAS catalog	Cholinergic synapse Voltage gated Potassium channels
		KCNS3	Unknown	29228715	GWAS catalog	Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
		KCNT1	Unknown	31826910	GWAS catalog	—
		KIAA0319	Unknown	29228715	GWAS catalog	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		KIAA1217	Unknown	29698419	GWAS catalog	—
		KIF13A	Unknown	38411962	GWAS catalog	Motor proteins
		KIF20B	Unknown	37340002 38872215	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KIF2B	Unknown	38538606	GWAS catalog	Motor proteins Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation +7 more
		KIRREL3	Unknown	38538606	GWAS catalog	Nephrin family interactions
		KLF13	Unknown	26586795	GWAS catalog	—
		KLF5	Unknown	30510241 31089142 36539618 38872215	GWAS catalog	Chemical carcinogenesis - receptor activation
		KLHL18	Unknown	23350875	GWAS catalog	—
		KLK15	Unknown	32887889	GWAS catalog	—
		KLK2	Unknown	32887889	GWAS catalog	Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption Activation of Matrix Metalloproteinases +2 more
		KLK3	Unknown	32887889	GWAS catalog	Pathways in cancer Prostate cancer Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) +1 more
		KRT2	Unknown	38411962	GWAS catalog	Keratinization Formation of the cornified envelope
		KRT5	Unknown	34290314	GWAS catalog	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
		KRT8	Unknown	27197191	GWAS catalog	Keratinization Formation of the cornified envelope
		L1TD1	Unknown	30529582	GWAS catalog	—
		LAIR2	Unknown	35512400	GWAS catalog	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
		LAMA5	Unknown	20972440 26965516 30510241 31089142 36539618 37340002 38408508 38538606 38872215	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +8 more
		LAMC1	Unknown	23266556 24836286 29917119 30510241 31089142 34594039 36539618 38872215 39392253	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +10 more
		LARP4B	Unknown	25866641	GWAS catalog	—
COLORECTAL CARCINOMA	EFO_1001951	LAMA5	Unknown	37965154	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +8 more
RECTUM CANCER	EFO_1000657	IL15	Unknown	36077729	GWAS catalog	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway TNF signaling pathway +5 more
		INPP4B	Unknown	36077729	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +3 more
		IQCM	Unknown	25866641	GWAS catalog	—
		LAMC1	Unknown	32887889	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +10 more
		LARP4B	Unknown	25866641	GWAS catalog	—

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Colorectal cancer

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