Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
COLORECTAL CANCER	MONDO_0005575	TNS1	Unknown	38538606	GWAS catalog	—
		TNS3	Unknown	24743840 31089142 36539618 38872215	GWAS catalog	MET interacts with TNS proteins
		TOM1L2	Unknown	34290314	GWAS catalog	—
		TOX	Unknown	31826910 36539618	GWAS catalog	—
		TOX2	Unknown	29471430 30510241 30529582 31089142 36539618 38872215	GWAS catalog	—
		TOX3	Unknown	32887889 37340002	GWAS catalog	—
		TPCN2	Unknown	38411962	GWAS catalog	Calcium signaling pathway Pancreatic secretion Stimuli-sensing channels
		TRA2B	Unknown	35512400	GWAS catalog	Spliceosome Alcoholic liver disease mRNA Splicing - Major Pathway
		TRAK2	Unknown	34290314	GWAS catalog	GABAergic synapse
		TRIM4	Unknown	36539618 38872215	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM46	Unknown	37340002	GWAS catalog	Interferon gamma signaling
		TRIM48	Unknown	33338681	GWAS catalog	Interferon gamma signaling
		TRIM71	Unknown	38411962	GWAS catalog	MicroRNAs in cancer Antigen processing: Ubiquitination & Proteasome degradation
		TRMT9B	Unknown	24743840	GWAS catalog	tRNA modification in the nucleus and cytosol
		TRPC4AP	Unknown	34290314	GWAS catalog	TRP channels
		TRPC6	Unknown	29228715 30510241 36539618	GWAS catalog	cGMP-PKG signaling pathway Axon guidance Effects of PIP2 hydrolysis +2 more
		TRPS1	Unknown	29228715	GWAS catalog	—
		TSHZ1	Unknown	26621817	GWAS catalog	—
		TSPAN18	Unknown	38538606	GWAS catalog	—
		TSPAN8	Unknown	36539618 38872215	GWAS catalog	—
		TTC22	Unknown	30510241 31089142 36539618 38872215	GWAS catalog	—
		TTC33	Unknown	29917119 30510241 31089142 34594039 36539618 37340002 38872215	GWAS catalog	—
		TTLL1	Unknown	38411962	GWAS catalog	—
		TUBA1C	Unknown	27197191	GWAS catalog	Phagosome Apoptosis Tight junction +33 more
		TULP4	Unknown	37340002	GWAS catalog	Neddylation
		TUT4	Unknown	35512400	GWAS catalog	Deadenylation of mRNA
		TWIST1	Unknown	25866641	GWAS catalog	Proteoglycans in cancer Interleukin-4 and Interleukin-13 signaling Regulation of RUNX2 expression and activity
		TYR	Unknown	32887889 33893285 34290314	GWAS catalog	Tyrosine metabolism Metabolic pathways Melanogenesis +1 more
		UBA2	Unknown	29228715	GWAS catalog	Ubiquitin mediated proteolysis SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
		UBAC1	Unknown	34290314	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		UBAP1	Unknown	38872215	GWAS catalog	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) +1 more
		UBAP2	Unknown	31826910	GWAS catalog	—
		UBE2Q1	Unknown	38538606	GWAS catalog	Ubiquitin mediated proteolysis Antigen processing: Ubiquitination & Proteasome degradation
		UBE2R2	Unknown	38872215	GWAS catalog	Ubiquitin mediated proteolysis Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
		UBQLN1	Unknown	31826910	GWAS catalog	Protein processing in endoplasmic reticulum Amyotrophic lateral sclerosis Cargo recognition for clathrin-mediated endocytosis
		UBTD2	Unknown	34290314	GWAS catalog	—
		UGT8	Unknown	36539618	GWAS catalog	Ether lipid metabolism Sphingolipid metabolism Metabolic pathways +1 more
		ULK2	Unknown	38538606	GWAS catalog	Autophagy - other Autophagy - animal mTOR signaling pathway +5 more
		UNC45A	Unknown	34981446	GWAS catalog	—
		UNC5CL	Unknown	34794066	GWAS catalog	—
		USH1G	Unknown	38538606	GWAS catalog	—
		USHBP1	Unknown	27197191	GWAS catalog	—
		USP29	Unknown	29228715	GWAS catalog	—
		USP47	Unknown	35512400	GWAS catalog	Ub-specific processing proteases
		VAPA	Unknown	35512400	GWAS catalog	Cholesterol metabolism Sphingolipid de novo biosynthesis Neutrophil degranulation +1 more
		VAV2	Unknown	36539618	GWAS catalog	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +24 more
		VCAN	Unknown	36539618	GWAS catalog	Cell adhesion molecules Cytoskeleton in muscle cells A tetrasaccharide linker sequence is required for GAG synthesis +12 more
		VNN1	Unknown	38538606	GWAS catalog	Pantothenate and CoA biosynthesis Metabolic pathways Post-translational modification: synthesis of GPI-anchored proteins +2 more
		VPS41	Unknown	29698419 35512400	GWAS catalog	Autophagy - animal Efferocytosis Salmonella infection
		VPS54	Unknown	38538606	GWAS catalog	Retrograde transport at the Trans-Golgi-Network
RECTUM CANCER	EFO_1000657	TWIST1	Unknown	25866641	GWAS catalog	Proteoglycans in cancer Interleukin-4 and Interleukin-13 signaling Regulation of RUNX2 expression and activity

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Colorectal cancer

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